Prospects for application of stem cells from adipose tissue in treating erectile dysfunction


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Although phosphodiesterase type 5 inhibitors are the first-line treatment of ED, some patients remain unresponsive to any pharmacotherapy. To date, the use of stem cells is considered as a new treatment modality for erectile dysfunction. The validity of this assumption has been experimentally proved in preclinical and clinical studies. The main focus is on the stem cells derived from adipose tissue, due to advantages over other sources.

Full Text

Restricted Access

About the authors

M. E Chaliy

Sechenov First Moscow State Medical University

Department of Urology

P. V Glybochko

Research Institute of Uronephrology and Human Reproductive Health of Sechenov First Moscow State Medical University

M. V Epifanova

Research Institute of Uronephrology and Human Reproductive Health of Sechenov First Moscow State Medical University

Email: Epifanova_maya@mail.ru

A. O Krasnov

Sechenov First Moscow State Medical University

Department of Urology

References

  1. Sanchez-Cruz J.J., Cabrera-Leon A., Martin-Morales A., Fernandez A., Burgos R., Rejas J. Male erectile dysfunction and health-related quality of life. Eur. Urol. 2003;44:245-253.
  2. Laumann E.O., West S., Glasser D., Carson C., Rosen R., Kang J.-h. Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: from the male attitudes regarding sexual health survey. J. Sex. Med. 2007;4:57-65.
  3. Пушкарь Д.Ю. Эпидемиологическое исследование распространенности эректильной дисфункции в РФ XII съезд Российского общества урологов. М., 2012.
  4. Глыбочко П.В., Аляев Ю.Г., Чалый М.Е., Ахвледиани Н.Д. Половые расстройства у мужчин. М. ГЭОТАР-Медиа. 2012.
  5. Carvalheira A.A., Pereira N.M., Maroco J., Forjaz V. Dropout in the treatment of erectile dysfunction with PDE5: a study on predictors and a qualitative analysis of reasons for discontinuation. J. Sex. Med. 2012;9:2361-2369.
  6. Zhang H., Albersen M., Jin X., Lin G. Stem cells. Novel players in the treatment of erectile dysfunction. Asian J. Androl. 2011;14:145-155.
  7. Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev. 2005;19:1129-1155.
  8. Becker C., Jakse G. Stem cells for regeneration of urological structures. Eur Urol. 2007;51:1217-1228.
  9. Evans M.J., Kaufman M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292:154-156.
  10. Kiefer J.C. Primer and interviews: the dynamic stem cell niche. Dev. Dyn. 2011;240:737-743.
  11. Voog J., Jones D.L. Stem cells and the niche: a dynamic duo. Cell Stem Cell. 2010;6:103-115.
  12. Albersen M., Kendirci M. Multipotent stromal cell therapy for cavernous nerve injury-induced erectile dysfunction. J. Sex. Med. 2012;9:385-403.
  13. Baraniak P.R., McDevitt T.C. Stem cell paracrine actions and tissue regeneration. Regener. Med. 2010;5:121-143.
  14. Piao S., Kim I.G., Lee J.Y., Hong S.H., Kim S.W., Hwang T.K., Oh S.H., Lee J.H., Ra J.C., Lee J.Y. Therapeutic effect of adipose-derived stem cells and BDNF-immobilized PLGA membrane in a rat model of cavernous nerve injury. J. Sex. Med. 2012;9:1968-1979.
  15. Lin C.S., Xin Z.C., Deng C.H., Ning H., Lin G., Lue T.F. Defining adipose tissue-derived stem cells in tissue and in culture. Histol. Histopathol. 2010;25:807-815.
  16. Strem B.M., Hicok K.C., Zhu M., Wulur I., Alfonso Z., Schreiber R.E., Fraser J.K., Hedrick M.H. Multipotential differentiation of adipose tissuederived stem cells. Keio J. Med. 2005;54:132-141.
  17. Qiu X., Fandel T.M., Ferretti L., Albersen M. Both immediate and delayed intracavernous injection of autologous adipose-derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury. Eur. Urol. 2012;62:720-727.
  18. Ryu J.-K., Tumurbaatar M., Jin H.-R., Kim W.J., Kwon M.-H., Piao S., Choi M.J. Intracavernous delivery of freshly isolated stromal vascular fraction rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse. J. Sex. Med. 2012;9:3051-3065.
  19. Varma M.J., Breuls R.G.M., Schouten T.E., Jurgens W.J.F.M., Van Ham S.M., Van Milligen F.J. Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. Stem Cells Dev. 2007;16:91-104.
  20. Garcia M.M., Fandel T.M., Lin G., Shindel A.W., Banie L., Lin C.-S., Lue T.F. Treatment of erectile dysfunction in the obese Type 2 diabetic ZDF rat with adipose tissuederived stem cells. J. Sex. Med. 2010;7:89-98.
  21. You D., Jang M. J. Comparative Study of Autologous Stromal Vascular Fraction and Adipose-Derived Stem Cells for Erectile Function Recovery in a Rat Model of Cavernous Nerve Injury. Stem Cells Trans Med. 2015;351-358.
  22. Bahk J.Y., Jung J.H., Han H., Min S.K., Lee Y.S. Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases. Exp. Clin. Transplant. 2010;8:150-160.
  23. Bochinski D., Lin G.T., Nunes L., Carrion R., Rahman N., Lin C.S., Lue T.F. The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int. 2004;94:904-909.
  24. Kim Y., deMiguel F., Usiene I., Kwon D., Yoshimura N., Huard J., Chancellor M.B. Injection of skeletal muscle-derived cells into the penis improves erectile function. Int. J. Impot. Res. 2006;18:329-334.
  25. Fall P.A., Izikki M., Tu L., Swieb S., Giuliano F., Bernabe J., Souktani R., Abbou C., Adnot S., Eddahibi S., Yiou R. Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction. Eur. Urol. 2009;56:716-726.
  26. Albersen M., Fandel T.M., Lin G., Wang G., Banie L., Lin C.-S., Lue T.F. Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J. Sex. Med. 2010;7:3331-3340.
  27. Kendirci M., Trost L., Bakondi B., Whitney M.J., Hellstrom W.J.G., Spees J.L. Transplantation of nonhematopoietic adult bone marrow stem progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. J. Urol. 2010;184:1560-1566.
  28. Lin G., Albersen M., Harraz A.M., Fandel T.M., Garcia M., McGrath M.H., Konety B.R., Lue T.F., Lin C.-S. Cavernous nerve repair with allogenic adipose matrix and autologous adipose-derived stem cells. Urology. 2011;77:1501-1509.
  29. Woo J.C., Bae W.J., Kim S.J., Kim S.D., Sohn D.W., Hong S.H., Lee J.Y., Hwang T.-K., Sung Y.C., Kim S.W. Transplantation of muscle-derived stem cells into the corpus cavernosumrestores erectile function in a rat model of cavernous nerve injury. Korean J. Urol. 2011;52:359-363.
  30. Kovanecz I., Rivera S., Nolazco G., Vernet D., Segura D. Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage. J. Sex. Med. 2012;9:2814-2826.
  31. Kim S.J., Choi S.W., Lee J.Y., Hwang T-K, Kim S.W. Synergistic effect of mesenchymal stem cells infected with recombinant adenovirus expressing human BDNF on erectile function in a rat model of cavernous nerve injury. Korean J. Urol. 2012;53:726-732.
  32. Fandel T.M., Albersen M., Lin G., Qiu X., Ning H., Banie L., Lue T.F., Lin C.-S. Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur. Urol. 2012;61:201-210.
  33. Piao S., Kim I.G., Lee J.Y. Therapeutic effect of adipose-derived stem cells and BDNF-immobilized PLGA membrane in a rat model of cavernous nerve injury. J. Sex. Med. 2012;9:1968-1979.
  34. Jeong H.H., Piao S., Ha J.N., Lee J.Y. Combined therapeutic effect of udenafil and adipose-derived stem cell (ADSC) brain-derived neurotrophic factor (BDNF)-membrane system in a rat model of cavernous nerve injury. Urology. 2013;81:1108.e1107-1108.e1114.
  35. Kim I.G., Piao S. Effect of an adipose-derived stemcell and nerve growth factor-incorporated hydrogel on recovery of erectile function in a rat model of cavernous nerve injury. Tissue Eng. A. 2013;19:14-23.
  36. You D., Jang M.J., Lee J., Jeong I.G. Periprostatic implantation of human bone marrow-derived mesenchymal stem cells potentiates recovery of erectile function by intracavernosal injection in a rat model of cavernous nerve injury. Urology. 2013;81:104-110.
  37. You D., Jang M.J., Lee J., Suh N. Comparative analysis of periprostatic implantation and intracavernosal injection of human adipose tissue-derived stem cells for erectile function recovery in a rat model of cavernous nerve injury. Prostate. 2013;73:278-286.
  38. Choi W.Y., Jeon H.G., Chung Y. Isolation and characterization of novel highly proliferative human CD34/CD73-double-positive testis-derived stem cells for cell therapy. Stem Cells Dev. 2013;22:2158-2173.
  39. Ying C., Yang M., Zheng X., Hu W., Wang X. Effects of intracavernous injection of adipose-derived stem cells on cavernous nerve regeneration in a rat model. Cell. Mol. Neurobiol. 2013;33:233-240.
  40. Ying C., Hu W., Cheng B., Yang M., Zheng X., Wang X. Erectile function restoration after repair of resected cavernous nerves by adipose-derived stem cells combined with autologous vein graft in rats. Cell. Mol. Neurobiol. 2014;34:393-402.
  41. Hwan L.S., Gul K.I. Combined effects of brain-derived neurotrophic factor immobilized poly-lactic-co-glycolic acidmembrane with human adipose-derived stemcells and basic fibroblast growth factor hydrogel on recovery of erectile dysfunction. Tissue Eng. A. 2014;20:2446-2454.
  42. Ryu J.-K., Kim D.-H. Intracavernous delivery of clonal mesenchymal stem cells restores erectile function in a mouse model of cavernous nerve injury. J. Sex. Med. 2014;11:411-423.
  43. Qiu X., Villalta J., Ferretti L. Effects of intravenous injection of adiposederived stem cells in a rat model of radiation therapy-induced erectile dysfunction. J. Sex. Med. 2012;9:1834-1841.
  44. Bivalacqua T.J., Deng W., Kendirci M. Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunctio. Am. J. Physiol. Heart Circ. Physiol. 2007;292:1278-1290.
  45. Nolazco G., Kovanecz I., Vernet D., Gelfand R.A., Tsao J., Ferrini M.G., Magee T., Rajfer J., Gonzalez-Cadavid N.F. Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int. 2008;101:1156-1164.
  46. Abdel Aziz M.T., El-Haggar S., Mostafa T., Atta H., Fouad H., Mahfouz S., Rashed L., Sabry D., Senbel A., Ali G.A. Effect ofmesenchymal stemcell penile transplantation on erectile signaling of aged rats. Andrologia. 2010;42:187-192.
  47. Gou X., He W.Y., Xiao M.Z., Qiu M., Wang M., Deng Y.Z., Liu C.D., Tang Z.B., Li J., Chen Y. Transplantation of endothelial progenitor cells transfected with VEGF165 to restore erectile function in diabetic rats. Asian J. Androl. 2011;13:332-338.
  48. Qiu X., Lin H., Wang Y., Yu W., Chen Y., Wang R., Dai Y. Intracavernous transplantation of bone marrow-derived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats. J. Sex. Med. 2011;8:427-436.
  49. Qiu X., Sun C., Yu W., Lin H. Combined strategy of mesenchymal stem cell injection with vascular endothelial growth factor gene therapy for the treatment of diabetes-associated erectile dysfunction. J. Androl. 2012;33:37-44.
  50. Sun C., Lin H., Yu W., Neurotrophic effect of bone marrow mesenchymal stem cells for erectile dysfunction in diabetic rats. Int. J. Androl. 2012;35:601-607.
  51. Nishimatsu H., Suzuki E., Kumano S. Adrenomedullin mediates adipose tissue-derived stem cell-induced restoration of erectile function in diabetic rats. J. Sex. Med. 2012;9:482-493.
  52. He Y., He W., Qin G., Luo J., Xiao M. Transplantation KCNMA1 modified bone marrow-mesenchymal stem cell therapy for diabetes mellitus-induced erectile dysfunction. Andrologia. 2013:479-486.
  53. Liu G., Sun X., Bian J. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. PLoS ONE. 2013:8 с.
  54. Ouyang B., Sun X., Han D. Human urine-derived stem cells alone or genetically-modified with FGF2 improve type 2 diabetic erectile dysfunction in a rat model. PLoS ONE. 2014;3:92825 e.
  55. Ryu J.-K., Tumurbaatar M., Jin H.-R. Intracavernous delivery of freshly isolated stromal vascular fraction rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse. J. Sex. Med. 2012;9:3051-3065.
  56. Das N.D., Song K.-M. Xenogenic transplantation of human breast adiposederived stromal vascular fraction enhances recovery of erectile function in diabetic mice. Biol. Reprod. 2014:90.
  57. Huang Y.-C., Ning H. The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a ratmodel. J. Sex.Med. 2010:7.
  58. Ma L., Yang Y., Sikka S.C. Adipose tissue-derived stem cell-seeded small intestinal submucosa for tunica albuginea grafting and reconstruction. Proc. Natl. Acad. Sci. 2012;109:2090-2095.
  59. Castiglione F., Hedlund P., Van der Aa F. Intratunical injection of human adipose tissue- derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie's disease. Eur. Urol. 2013;63:551-560.
  60. Gokce A., Abd Elmageed Z.Y., Lasker G.F. Adipose tissue-derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie's disease. Andrology. 2014;2:244-251.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies