Hypofractionated radiation therapy for localized prostate cancer (first experience)
- Authors: Vorob'eva T.G1, Bednyj I.V1, Drobjazgin E.A1,2, Polovnikov E.S1
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Affiliations:
- Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy
- Novosibirsk State Medical University
- Issue: No 1 (2016)
- Pages: 70-74
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/282353
- ID: 282353
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Abstract
This paper presents a study of 74 prostate cancer patients divided into 2 groups (study group and comparison group). The comparison group patients (n=50) were treated with radiation therapy in standard fractionated mode, while study group patients (n=24) underwent hypofractionated radiation therapy (STD 7.5 Gy; TTD 37.5 Gy). Early radiation-induced complications occurred only in the comparison group patients. Late radiation-induced complications were observed in 4 and 8 patients in the study group and the comparison group, respectively. Significant statistic differences in quality of life between groups were found in patients with excellent (FET; p=0.0145) and satisfactory (FET; p=0.03) well-being. Hypofractionated radiation therapy is safe given that the necessary technical and clinical conditions are observed. It significantly reduces treatment time and enables quickly bringing a course of radiation therapy to radical doses. This is a noninvasive treatment that significantly reduces risks and cost of procedures.
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About the authors
T. G Vorob'eva
Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy
I. V Bednyj
Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy
Email: p_filatov@nricp .ru
E. A Drobjazgin
Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy; Novosibirsk State Medical University
Email: evgenyidrob@inbox.ru
E. S Polovnikov
Academician E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Center of Oncology and Radiotherapy
Email: drojo@mail.ru
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