USING CELL TECHNOLOGIES TO TREAT UROLOGIC DISEASES


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Abstract

Stem and progenitor cells being introduced into the body have the ability to stimulate regeneration of tissues and organs by differentiating into specialized cells. Stem cell therapy is used in urology to treat various disorders, including erectile dysfunction, urinary incontinence, Peyronie’s disease, and male infertility. This review presents the results of international preclinical and clinical research on stem cell based medications for treating the above diseases. The most promising appears to be the use of adipose tissue-derived mesenchymal stem cells.

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About the authors

P. V Glybochko

Sechenov First Moscow State Medical University, Research Institute of Uronephrology and Human Reproductive Health

Email: rectorat@mma.ru

Yu. V Olefir

Scientific Center on Expertise of Medical Application Products

Yu. G Alyaev

Sechenov First Moscow State Medical University, Research Institute of Uronephrology and Human Reproductive Health

Email: ugalyaev@mail.ru

D. V Butnaru

Sechenov First Moscow State Medical University, Research Institute of Uronephrology and Human Reproductive Health

Email: butnaru_dv@mail.ru
PhD, Deputy Director

E. A Bezrukov

Sechenov First Moscow State Medical University, Research Institute of Uronephrology and Human Reproductive Health

Email: eabezrukov@rambler.ru

A. A Chaplenko

Scientific Center on Expertise of Medical Application Products

T. M Zharikova

Sechenov First Moscow State Medical University, Research Institute of Uronephrology and Human Reproductive Health

Email: tanyushaz@mail.ru

References

  1. Becker C., Jakse G. Stem cells for regeneration of urological structures. Eur Urology. 2003;51:1217-1228.
  2. Kiefer J.C. Primer and interviews: The dynamic stem cell niche. Dev Dyn. 2011;240:737-743.
  3. Schover L.R., Brey K., Lichtin A., Lipshultz L.I., Jeha S. Oncologists’ attitudes and practices regarding banking sperm before cancer treatment. J Clin Oncol. 2002;20:1890-1897.
  4. Meistrich M.L., Finch M., da Cunha M.F., Hacker U., Au W.W. Damaging effects of fourteen chemotherapeutic drugs on mouse testis cells. Cancer Res. 1982;42:122-131.
  5. Yokonishi T., Sato T., Komeya M., Katagiri K., Kubota Y., Nakabayashi K., Hata K., Inoue K., Ogonuki N., Ogura A., Ogawa T. Offspring production with sperm grown in vitro from cryopreserved testis tissues. Nat Commun. 2014;5:4320.
  6. Sanchez-Cruz J.J., Cabrera-Leon A., Martin-Morales A., Fernandez A., Burgos R., Rejas J. Male erectile dysfunction and healthrelated quality of life. Eur Urol. 2003;44:245-253.
  7. Laumann E.O., West S., Glasser D., Carson C., Rosen R., Kang J.H. Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: from the male attitudes regarding sexual health survey. J Sex Med. 2007;4:57-65.
  8. Carvalheira A.A., Pereira N.M., Maroco J., Forjaz V. Dropout in the treatment of erectile dysfunction with PDE5: a study on predictors and a qualitative analysis of reasons for discontinuation. J Sex Med. 2012;9:2361-2369.
  9. Lin C.S., Xin Z., Dai J., Huang Y.C., Lue T.F. Stem-cell therapy for erectile dysfunction. Expert Opin Biol Ther. 2013;13:1585-1597.
  10. Carrier S., Nagaraju P., Morgan D.M., Baba K., Nunes L., Lue T.F. Age decreases nitric oxide synthase-containing nerve fibers in the rat penis. J Urol. 1997;157:1088-1092.
  11. Azadzoi K.M., Schulman R.N., Aviram M., Siroky M.B. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J Urol. 2005;174:386-393.
  12. Wespes E. Erectile dysfunction in the ageing man. Curr Opin Urol. 2000;10:625-628.
  13. Dashwood M.R., Crump A., Shi-Wen X., Loesch A. Identification of neuronal nitric oxide synthase (nNOS) in human penis: a potential role of reduced neuronally-derived nitric oxide in erectile dysfunction. Curr Pharm Biotechnol. 2011;12:1316-1321.
  14. Huang Y.C., Ning H., Shindel A.W., Fandel T.M., Lin G., Harraz A.M., Lue T.F., Lin C.S. The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model. J Sex Med. 2010;7(1):1391-1400.
  15. Ficarra V., Novara G., Artibani W., Cestari A., Galfano A., Graefen M., Guazzoni G., Guillonneau B., Menon M., Montorsi F., Patel V., Rassweiler J., Van Poppel H. Retropubic, laparoscopic, and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies. Eur Urol. 2009;55:1037-1063.
  16. Fode M., Ohl D.A., Ralph D., Sonksen J. Penile rehabilitation after radical prostatectomy: what the evidence really says. BJU Int. 2013;112:998-1008.
  17. Carrier S., Hricak H., Lee S.S., Baba K., Morgan D.M., Nunes L., Ross G.Y., Phillips T.L., Lue T.F. Radiation-induced decrease in nitric oxide synthase: containing nerves in the rat penis. Radiology. 1995;195:95-99.
  18. Bochinski D., Lin G.T., Nunes L., Carrion R., Rahman N., Lin C.S., Lue T.F. The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int. 2004;94:904-909.
  19. Gou X., He W.Y., Xiao M.Z., Qiu M., Wang M., Deng Y.Z., Liu C.D., Tang Z.B., Li J., Chen Y. Transplantation of endothelial progenitor cells transfected with VEGF165 to restore erectile function in diabetic rats. Asian J Androl. 2011;13:332-3328.
  20. Qiu X., Lin H., Wang Y., Yu W., Chen Y., Wang R., Dai Y. Intracavernous transplantation of bone marrow-derived mesenchymal stem cells restores erectile function of streptozocin-induced diabetic rats. J Sex Med. 2011;8:427-436.
  21. Fall P.A., Izikki M., Tu L., Swieb S., Giuliano F., Bernabe J., Souktani R., Abbou C., Adnot S., Eddahibi S., Yiou R. Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction. Eur Urol. 2009;56:716-725.
  22. Bivalacqua T.J., Deng W., Kendirci M., Usta M.F., Robinson C., Taylor B.K., Murthy S.N., Champion H.C., Hellstrom W.J., Kadowitz P.J. Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Am J Physiol Heart Circ Physiol. 2007;292:1278-1290.
  23. Hwang J.H., Yuk S.H., Lee J.H., Lyoo W.S., Ghil S.H., Lee S.S., Khang I.G., Paik S.Y., Lee J.Y. Isolation of muscle derived stem cells from rat and its smooth uscle differentiation. Mol Cells. 2004;17:57-61.
  24. Kim Y., de Miguel F., Usiene I., Kwon D., Yoshimura N., Huard J., Chancellor M.B. Injection of skeletal muscle-derived cells into the penis improves erectile function. Int J Impot Res. 2006;18:329-334.
  25. Song Y.S., Lee H.J., Park I.H., Lim I.S., Ku J.H., Kim S.U. Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction. BJU Int. 2008;102:220-224.
  26. Qiu X., Fandel T.M., Ferretti L., Albersen M., Orabi H., Zhang H., Lin G., Lin C.S., Schroeder T., Lue T.F. Both immediate and delayed intracavernous injection of autologous adipose-derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury. Eur Urol. 2012;62:720-727.
  27. Ryu J.K., Tumurbaatar M., Jin H.R., Kim W.J., Kwon M.H., Piao S., Choi M.J., Yin G.N., Song K.M., Kang Y.J., Koh Y.J., Koh G.Y., Suh J.K. Intracavernous delivery of freshly isolated stromal vascular fraction rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse. J Sex Med. 2012;9:3051-3065.
  28. Ning H., Liu G., Lin G., Yang R., Lue T.F., Lin C.S. Fibroblast growth factor 2 promotes endothelial differentiation of adipose tissue-derived stem cells. J Sex Med. 2009;6:967-979.
  29. Ouyang B., Sun X., Han D., Chen S., Yao B., Gao Y., Bian J., Huang Y., Zhang Y., Wan Z., Yang B., Xiao H., Songyang Z., Liu G., Zhang Y., Deng C. Human urine-derived stem cells alone or genetically-modified with FGF2 Improve type 2 diabetic erectile dysfunction in a rat model. PLoS One. 2014;9:e92825.
  30. Qiu X., Villalta J., Ferretti L., Fandel T.M., Albersen M., Lin G., Dai Y., Lue T.F., Lin C.S. Effects of intravenous injection of adipose-derived stem cells in a rat model of radiation therapy-induced erectile dysfunction. J Sex Med. 2012;9:1834-1841.
  31. Kim S.J., Choi S.W., Hur K.J., Park S.H., Sung Y.C., Ha Y.S., Cho H.J., Hong S.H., Lee J.Y., Hwang T.K., Kim S.W. Synergistic effect of mesenchymal stem cells infected with recombinant adenovirus expressing human BDNF on erectile function in a rat model of cavernous nerve injury. Korean J Urol. 2012;53:726-732.
  32. Choi W.Y., Jeon H.G., Chung Y., Lim J.J., Shin D.H., Kim J.M., Ki B.S., Song S.H., Choi S.J., Park K.H., Shim S.H., Moon J., Jung S.J., Kang H.M., Park S., Chung H.M., Ko J.J., Cha K.Y., Yoon T.K., Kim H., Lee D.R Isolation and characterization of novel, highly proliferative human CD34/CD73-double-positive testis-derived stem cells for cell therapy. Stem Cells Dev. 2013;22:2158-2173.
  33. You D., Jang M.J., Lee J., Jeong I.G., Kim H.S., Moon K.H., Suh N., Kim C.S. Periprostatic implantation of human bone marrow-derived mesenchymal stem cells potentiates recovery of erectile function by intracavernosal injection in a rat model of cavernous nerve injury. Urology. 2013;81:104-110.
  34. You D., Jang M.J., Lee J., Suh N., Jeong I.G., Sohn D.W., Kim S.W., Ahn T.Y., Kim C.S. Comparative analysis of periprostatic implantation and intracavernosal injection of human adipose tissue-derived stem cells for erectile function recovery in a rat model of cavernous nerve injury. Prostate. 2013;73:278-286.
  35. Ryu J.K., Kim D.H., Song K.M., Yi T., Suh J.K., Song S.U. Intracavernous delivery of clonal mesenchymal stem cells restores erectile function in a mouse model of cavernous nerve injury. J Sex Med. 2014;11:411-23. 59.
  36. Smith J.F., Walsh T.J., Conti S.L., Turek P., Lue T. Risk factors for emotional and relationship problems in Peyronie’s disease. J Sex Med. 2008;5:2179-2184. 60.
  37. Gonzalez-Cadavid N.F., Rajfer J. Mechanisms of disease: new insights into the cellular and molecular pathology of Peyronie’s disease. Nat Clin Pract Urol. 2005;2:291-297. 61.
  38. Devine C.J. Jr. International Conference on Peyronie’s disease advances in basic and clinical research. March 17-19, 1993. Introduction. J Urol. 1997;157:272-275.
  39. Gonzalez-Cadavid N.F., Magee T.R., Ferrini M., Qian A., Vernet D., 62. Rajfer J. Gene expression in Peyronie’s disease. Int J Impot Res. 2002;14:361-374.
  40. Tal R., Heck M., Teloken P., Siegrist T., Nelson C.J., Mulhall J.P. 63. Peyronie’s disease following radical prostatectomy: incidence and predictors. J Sex Med. 2010;7:1254-1361.
  41. Vernet D., Nolazco G., Cantini L., Magee T.R., Qian A., Rajfer J., Gonzalez-Cadavid N.F. Evidence that osteogenic progenitor cells in the 64. human tunica albuginea may originate from stem cells: implications for peyronie disease. Biol Reprod. 2005;73:1199-1210.
  42. Shindel A.W. Sexual dysfunction: The potential of stem cell therapy for Peyronie disease. Nat Rev Urol. 2013;10:8-9. 65.
  43. Lin C.S., Lin G., Lue T.F. Allogeneic and xenogeneic transplantation of adipose-derived stem cells in immunocompetent recipients without immunosuppressants. Stem Cells Dev. 2012;21:2770-2778.
  44. Chamberlain G., Fox J., Ashton B., Middleton J. Concise review: 66. mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007;25:2739-2749.
  45. Zhang H., Ning H., Banie L., Wang G., Lin G., Lue T.F., Lin C.S. 67. Adipose tissue-derived stem cells secrete CXCL5 cytokine with chemoattractant and angiogenic properties. Biochem Biophys Res Commun. 2010;402:560-564.
  46. Castiglione F., Hedlund P., Van der Aa F., Bivalacqua T.J., Rigatti P., 68. Van Poppel H., Montorsi F., De Ridder D., Albersen M. Intratunical injection of human adipose tissue-derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie’s disease. Eur Urol. 2013;63:551-560.
  47. Alwaal A., Hussein A., Lin C., Lue T.F. Prospects of stem cell treatment 69. in benign urological diseases. Korean J Urol. 2015;56:257-265.
  48. Lin C.S., Lue T.F. Stem cell therapy for stress urinary incontinence: a critical review. Stem Cells Dev. 2012;21:834-843.
  49. Delancey J.O. Why do women have stress urinary incontinence? 70. Neurourol Urodyn. 2010;29(1):13-17.
  50. Lin C.S. Stem cell therapy for the bladder: where do we stand? J Urol. 2011;185:779-780. 71.
  51. Lin G., Wang G., Banie L., Ning H., Shindel A.W., Fandel T.M., Lue T.F., Lin C.S. Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Cytotherapy. 2010;12:88-95. 72.
  52. Chancellor M.B., Yokoyama T., Tirney S., Mattes C.E., Ozawa H., Yoshimura N., de Groat W.C., Huard J. Preliminary results of myoblast injection into the urethra and bladder wall: a possible method for the treatment of stress urinary incontinence and impaired detrusor 73. contractility. Neurourol Urodyn. 2000;19:279-287.
  53. Yiou R., Dreyfus P., Chopin D.K., Abbou C.C., Lefaucheur J.P. Muscle precursor cell autografting in a murine model of ure thral sphincter 74. injury. BJU Int. 2002;89:298-302.
  54. Corcos J., Loutochin O., Campeau L., Eliopoulos N., Bouchentouf M., Blok B., Galipeau J. Bone marrow mesenchymal stromal cell therapy for external urethral sphincter restoration in a rat model of stress urinary 75. incontinence. Neurourol Urodyn. 2011;30:447-455.
  55. Kinebuchi Y., Aizawa N., Imamura T., Ishizuka O., Igawa Y., Nishizawa O. Autologous bone-marrow-derived mesenchymal stem 76. cell transplantation into injured rat urethral sphincter. Int J Urol. 2010;17:359-368.
  56. Kim S.O., Na H.S., Kwon D., Joo S.Y., Kim H.S., Ahn Y. Bone-marrow-derived mesenchymal stem cell transplantation enhances closing 77. pressure and leak point pressure in a female urinary incontinence rat model. Urol Int. 2011;86:110-116.
  57. Zou X.H., Zhi Y.L., Chen X., Jin H.M., Wang L.L., Jiang Y.Z., Yin Z., Ouyang H.W. Mesenchymal stem cell seeded knitted silk sling for the 78. treatment of stress urinary incontinence. Biomaterials. 2010;31:4872-79.
  58. Dissaranan C., Cruz M.A., Kiedrowski M.J., Balog B.M., Gill B.C., Penn M.S., Goldman H.B., Damaser M.S. Rat mesenchymal stem cell secretome promotes elastogenesis and facilitates recovery from 79. simulated childbirth injury. Cell Transplant. 2014;23:1395-1406.
  59. Lee C.N., Jang J.B., Kim J.Y., Koh C., Baek J.Y., Lee K.J. Human cord blood stem cell therapy for treatment of stress urinary incontinence. J Korean Med Sci. 2010;25:813-816.
  60. Fu Q., Song X.F., Liao G.L., Deng C.L., Cui L. Myoblasts differentiated from adipose-derived stem cells to treat stress urinary incontinence. Urology. 2010;75:718-723.
  61. Watanabe T., Maruyama S., Yamamoto T., Kamo I., Yasuda K., Saka Y., Ozaki T., Yuzawa Y., Matsuo S., Gotoh M. Increased urethral resistance by periurethral injection of low serum cultured adipose-derived mesenchymal stromal cells in rats. Int J Urol. 2011;18:659-666.
  62. Wu G., Song Y., Zheng X., Jiang Z. Adipose-derived stromal cell transplantation for treatment of stress urinary incontinence. Tissue Cell. 2011;43:246-253.
  63. Zhao W., Zhang C., Jin C., Zhang Z., Kong D., Xu W., Xiu Y. Periurethral injection of autologous adipose-derived stem cells with controlled-release nerve growth factor for the treatment of stress urinary incontinence in a rat model. Eur Urol. 2011;59:155-163.
  64. Li G.Y., Zhou F., Gong Y.Q., Cui W.S., Yuan Y.M., Song W.D., Xin H., Liu T., Li W.R., Gao Z.Z., Liu J., Guo Y.L., Xin Z.C. Activation of VEGF and ERK1/2 and improvement of urethral function by adipose-derived stem cells in a rat stress urinary incontinence model. Urology. 2012;80:953.e1-8.
  65. Shi L.B., Cai H.X., Chen L.K., Wu Y., Zhu S.A., Gong X.N., Xia Y.X., Ouyang H.W., Zou X.H. Tissue engineered bulking agent with adipose-derived stem cells and silk fibroin microspheres for the treatment of intrinsic urethral sphincter deficiency. Biomaterials 2014;35:1519-1530.
  66. Kim B.S., Chun S.Y., Lee J.K., Lim H.J., Bae J.S., Chung H.Y., Atala A., Soker S., Yoo J.J., Kwon T.G. Human amniotic fluid stem cell injection therapy for urethral sphincter regeneration in an animal model. BMC Med. 2012;10:94.
  67. Chun S.Y., Cho D.H., Chae S.Y., Choi K.H., Lim H.J., Yoon G.S., Kim B.S., Kim B.W., Yoo J.J., Kwon T.G. Human amniotic fluid stem cell-derived muscle progenitor cell therapy for stress urinary incontinence. J Korean Med Sci. 2012;27:1300-1307.
  68. Chun S.Y., Kwon J.B., Chae S.Y., Lee J.K., Bae J.S., Kim B.S., Kim H.T., Yoo E.S., Lim J.O., Yoo J.J., Kim W.J., Kim B.W., Kwon T.G. Combined injection of three different lineages of early differentiating human amniotic fluid-derived cells restores urethral sphincter function in urinary incontinence. BJU Int. 2014;114:770-783.
  69. Badra S., Andersson K.E., Dean A., Mourad S., Williams J.K. Long-term structural and functional effects of autologous muscle precursor cell therapy in a nonhuman primate model of urinary sphincter deficiency. J Urol. 2013;190:1938-1945.
  70. Jiang H.H., Damaser M. Animal models of stress urinary incontinence. In: Andersson K.E, Michel M.C, editors. Urinary tract. Berlin: Springer. 2011:45-67.
  71. Lin A.S., Carrier S., Morgan D.M., Lue T.F. Effect of simulated birth trauma on the urinary continence mechanism in the rat. Urology. 1998;52:143-151.
  72. Sievert K.D., Emre Bakircioglu M., Tsai T., Dahms S.E., Nunes L., Lue T.F. The effect of simulated birth trauma and/or ovariectomy on rodent continence mechanism. Part I: functional and structural change. J Urol. 2001;166:311-317.
  73. Pauwels E., De Wachter S., Wyndaele J.J. Evaluation of different techniques to create chronic urinary incontinence in the rat. BJU Int. 2009;103:782-785.
  74. Rodriguez L.V., Chen S., Jack G.S., de Almeida F., Lee K.W., Zhang R. New objective measures to quantify stress urinary incontinence in a novel durable animal model of intrinsic sphincter deficiency. Am J Physiol Regul Integr Comp Physiol. 2005;288:1332-1338
  75. Lin Y.H., Liu G., Li M., Xiao N., Daneshgari F. Recovery of continence function following simulated birth trauma involves repair of muscle and nerves in the urethra in the female mouse. Eur Urol. 2010;57:506-512.
  76. Mitterberger M., Marksteiner R., Margreiter E., Pinggera G.M., Colleselli D., Frauscher F., Ulmer H., Fussenegger M., Bartsch G., Strasser H. Autologous myoblasts and fibroblasts for female stress incontinence: a 1-year follow-up in 123 patients. BJU Int. 2007;100:1081-1085.
  77. Mitterberger M., Marksteiner R., Margreiter E., Pinggera G.M., Frauscher F., Ulmer H., Fussenegger M., Bartsch G., Strasser H. Myoblast and fibroblast therapy for post-prostatectomy urinary incontinence: 1-year followup of 63 patients. J Urol. 2008;179:226-231.
  78. Mitterberger M., Pinggera G.M., Marksteiner R., Margreiter E., Fussenegger M., Frauscher F., Ulmer H., Hering S., Bartsch G., Strasser H. Adult stem cell therapy of female stress urinary incontinence. Eur Urol. 2008;53:169-175
  79. Strasser H., Marksteiner R., Margreiter E., Mitterberger M., Pinggera G.M., Frauscher F., Fussenegger M., Kofler K., Bartsch G. Transurethral ultrasonographyguided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence. World J Urol. 2007;25:385-392.
  80. Strasser H., Marksteiner R., Margreiter E., Pinggera G.M., Mitterberger M., Frauscher F., Ulmer H., Fussenegger M., Kofler K., Bartsch G. Autologous myoblasts and fibroblasts versus collagen for treatment of stress urinary incontinence in women: a randomised controlled trial. Lancet. 2007;369:2179-2186.
  81. Carr L.K., Steele D., Steele S., Wagner D., Pruchnic R., Jankowski R., Erickson J., Huard J., Chancellor M.B. 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19:881-883.
  82. Yamamoto T., Gotoh M., Hattori R., Toriyama K., Kamei Y., Iwaguro H., Matsukawa Y., Funahashi Y. Periurethral injection ofautologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: report of two initial cases. Int J Urol. 2010;17:75-82.
  83. Sèbe P., Doucet C., Cornu J.N., Ciofu C., Costa P., de Medina S.G., Pinset C., Haab F. Intrasphincteric injections of autologous muscular cells in women with refractory stress urinary incontinence: a prospective study. Int Urogynecol J. 2011;22:183-189.
  84. Yamamoto T., Gotoh M., Kato M., Majima T., Toriyama K., Kamei Y., Iwaguro H., Matsukawa Y., Funahashi Y. Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence: Report of three initial cases. Int J Urol. 2012;19:652-659.
  85. Gotoh M., Yamamoto T., Kato M., Majima T., Toriyama K., Kamei Y., Matsukawa Y., Hirakawa A., Funahashi Y. Regenerative treatment of male stress urinary incontinence by periurethral injection of autologous adipose-derived regenerative cells: 1-year outcomes in 11 patients. Int J Urol. 2014;21:294-300.
  86. Stangel-Wojcikiewicz K., Jarocha D., Piwowar M., Jach R., Uhl T., Basta A., Majka M. Autologous muscle-derived cells for the treatment of female stress urinary incontinence: a 2-year follow-up of a Polish investigation. Neurourol Urodyn. 2014;33:324-330.
  87. Kuismanen K., Sartoneva R., Haimi S., Mannerström B., Tomäs E., Miettinen S., Nieminen K. Autologous adipose stem cells in treatment of female stress urinary incontinence: results of a pilot study. Stem Cells Transl Med. 2014;3:936-941.
  88. Lee J.Y., Cannon T.W., Pruchnic R., Fraser M.O., Huard J., Chancellor M.B. The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 2003;14:31-37.
  89. Yiou R., Yoo J.J., Atala A. Restoration of functional motor units in a rat model of sphincter injury by muscle precursor cell autografts. Transplantation. 2003;76:1053-1060.
  90. Cannon T.W., Lee J.Y., Somogyi G., Pruchnic R., Smith C.P., Huard J., Chancellor M.B. Improved sphincter contractility after allogenic musclederived progenitor cell injection into the denervated rat urethra. Urology. 2003;62:958-963.
  91. Chermansky C.J., Tarin T., Kwon D.D., Jankowski R.J., Cannon T.W., de Groat W.C., Huard J., Chancellor M.B. Intraurethral muscle-derived cell injections increase leak point pressure in a rat model of intrinsic sphincter deficiency. Urology. 2004;63:780-785.
  92. Lee J.Y., Paik S. Y., Yuk S.H., Lee J.H., Ghil S.H., Lee S.S. Long term effects of muscle-derived stem cells on leak point pressure and closing pressure in rats with transected pudendal nerves. Mol Cells. 2004;18:309-313.
  93. Yiou R., Yoo J.J., Atala A. Failure of differentiation into mature myotubes by muscle precursor cells with the side-population phenotype after injection into irreversibly damaged striated urethral sphincter. Transplantation. 2005;80:131-133.
  94. Kwon D., Kim Y., Pruchnic R., Jankowski R., Usiene I., de Miguel F., Huard J., Chancellor M.B. Periurethral cellular injection: comparison of musclederived progenitor cells and fibroblasts with regard to efficacy and tissue contractility in an animal model of stress urinary incontinence. Urology. 2006;68:449-454.
  95. Kim Y.T., Kim D.K., Jankowski R.J., Pruchnic R., Usiene I., de Miguel F., Chancellor M.B. Human muscle-derived cell injection in a rat model of stress urinary incontinence. Muscle Nerve. 2007;36:391-393.
  96. Hoshi A., Tamaki T., Tono K., Okada Y., Akatsuka A., Usui Y., Terachi T. Reconstruction of radical prostatectomy-induced urethral damage using skeletal muscle-derived multipotent stem cells. Transplantation. 2008;85:1617-1624.
  97. Furuta A., Jankowski R.J., Pruchnic R., Egawa S., Yoshimura N., Chancellor M.B. Physiological effects of human muscle-derived stem cell implantation on urethral smooth muscle function. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19:1229-1234.
  98. Lim J.J., Jang J.B., Kim J.Y., Moon S.H., Lee C.N., Lee K.J. Human umbilical cord blood mononuclear cell transplantation in rats with intrinsic sphincter deficiency. J Korean Med Sci. 2010;25:663-670.
  99. Xu Y., Song Y.F., Lin Z.X. Transplantation of muscle-derived stem cells plus biodegradable fibrin glue restores the urethral sphincter in a pudendal nerve-transected rat model. Braz J Med Biol Res. 2010;43:1076-1083.
  100. Kalinina N.I., Sysoeva V.Y., Rubina K.A., Parfenova E.V., Tkachuk V.A. Mesenchymal stem cells in tissue growth and repair. Acta Naturae. 2011;4:30-37.

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