Metabolic syndrome as a cause of reduced ejaculate fertility in patients with prostatic tuberculosis


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Introduction: Metabolic syndrome (MS) negatively affects the quality of ejaculate, especially in patients with chronic prostatitis. Material and methods: To determine the effect of metabolic syndrome on semen parameters in patients with tuberculosis of the prostate (TP), a study of 72 patients with prostatic tuberculosis was conducted. MS was diagnosed when at least three of the five following medical conditions were found: central obesity, elevated levels of plasma triglycerides, high blood pressure, hyperglycemia and decreased levels of high-density lipoproteins. Semen parameters were compared in patients with tuberculosis of the prostate with and without MS. Results: 41% of patients with prostatic tuberculosis had metabolic syndrome, which was associated with a 1.5, 1.4 and 2.5 fold decreases in the number of sperm, sperm concentration, and the number of normal sperm forms, respectively. Conclusions: These findings provide the rationale for developing specific therapies aimed at restoring ejaculate fertility in patients with prostatic tuberculosis, considering that almost a half of them have MS.

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Sobre autores

A. Osadchii

Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia; Novosibirsk State Medical University of Minzdrav of Russia

Email: urotub@yandex.ru

E. Kulchavenya

Novosibirsk Tuberculosis Research Institute of Minzdrav of Russia; Novosibirsk State Medical University of Minzdrav of Russia

Email: urotub@yandex.ru
Dr.Med.Sci., Prof., Principal Research Fellow at TB Research Institute, Prof. at Department of Tuberculosis of NSMU

Bibliografia

  1. Eckel R.H., Alberti K.G., Grundy S.M., Zimmet P.Z. The metabolic syndrome. Lancet. 2010;375:181-183.
  2. Corona G., Rastrelli G., Vignozzi L., Mannucci E., Maggi M. Testosterone, cardiovascular disease and the metabolic syndrome. Best Pract Res Clin Endocrinol Metab. 2011;25:337-353.
  3. Corona G., Rastrelli G., Morelli A., Vignozzi L., Mannucci E., Maggi M. Hypogonadism and metabolic syndrome. J. Endocrinol Invest. 2011;34:557-567.
  4. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) JAMA. 2001;285:2486-2497.
  5. Lotti F., Corona G., Vignozzi L., Rossi M., Maseroli E., Cipriani S., Gacci M., Forti G., Maggi M. Metabolic syndrome and prostate abnormalities in male subjects of infertile couples Asian J. Androl. 2014;16(2):295-304.
  6. Fibbi B., Penna G., Morelli A., Adorini L., Maggi M. Chronic inflammation in the pathogenesis of benign prostatic hyperplasia. Int J. Andr. 2009;32:1-15.
  7. Lotti F., Corona G., Mancini M., Filimberti E., Degli Innocenti S., Colpi G.M., Baldi E., Noci I., Forti G., Adorini L., Maggi M. Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility. Int J. Androl. 2011;34:600-613.
  8. Жукова И.И., Кульчавеня Е.В., Холтобин Д.П., Брижатюк Е.В., Хомяков В.Т., Осадчий А.В. Туберкулез мочеполовой системы сегодня. Урология. 2013;1:13-16
  9. Кульчавеня Е.В., Неймарк А.И. Простатит. Диагностика и лечение: руководство. М.:ГЭОТАР-Медиа. 2010:256 с.
  10. Щербань М.Н., Кульчавеня Е.В., Брижатюк Е.В. Диагностика, предупреждение и лечение нарушений репродуктивной функции у мужчин, больных туберкулезом лёгких. Туберкулёз и болезни лёгких. 2010;10:31-36
  11. Кульчавеня Е.В., Брижатюк Е.В., Баранчукова А.А., Чередниченко А.Г., Климова И.П. Алгоритм диагностики туберкулеза предстательной железы. Туберкулез и болезни легких. 2014;5:10-15
  12. Kulchavenya E. Best practice in the diagnosis and management of Urogenital Tuberculosis. Ther Adv Urol. 2013;5(3): 143-51. doi: 10.1177/1756287213476128.
  13. Lotti F., Corona G., Degli Innocenti S., Filimberti E., Scognamiglio V., Vignozzi L., Forti G., Maggi M. Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples. Andrology. 2013;1:229-239.
  14. Тюзиков И.А. Особенности персистенции инфекции предстательной железы у мужчин с сахарным диабетом. Андрология и генитальная хирургия. 2011;2:30-34
  15. Stenholm S., Koster A., Alley D.E., Visser M., Maggio M., Harris T.B., Egan J.M., Bandinelli S., Guralnik J.M., Ferrucci L. Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study. Clin Endocrinol (Oxf). 2010;73(1):55-65. doi: 10.1111/j.1365-2265.2009.03742.x.
  16. Saltevo J., Laakso M., Jokelainen J., Keinänen-Kiukaanniemi S., Kumpusalo E., Vanhala M. Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with insulin sensitivity: a population-based study. Diabetes Metab Res Rev. 2008;24(5):378-83. doi: 10.1002/dmrr.831.
  17. Kalyani R.R., Dobs A.S. Androgen deWciency, diabetes, and the metabolic syndrome in men. Curr Opin Endocrinol Diabetes Obes. 2007 14:226-234.
  18. Kort H.I., Massey J.B., Ebner C.W. Impact ofbody mass index values on sperm quantity and quality. J. Androl. 2006;27:450-452.
  19. Kasturi S.S., Tannir J., Brannigan R.E. The metabolic syndrome and male infertility. J. Androl. 2008;29:251-259.
  20. Nguyen R.H., Wilcox A.J., Skjaerven R., Baird D.D. Men’s body mass index and infertility. Hum Reprod 2007;22:2488-2493.

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