High oncogenic risk human papillomavirus and urinary bladder cancer


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Abstract

Aim. To determine the role of human papillomavirus (HPV) of high oncogenic risk in the development of urinary bladder cancer. Materials and methods. 100 patients (72 men and 28 women) aged 38 to 90 years (mean age 65±10 years) diagnosed with bladder cancer were examined and underwent treatment. Clinical assessment was complemented by enzyme-linked immunosorbent assays for the presence of antiviral antibodies to herpes simplex virus (HSV) type 1 and type 2, cytomegalovirus (CMV), Epstein-Barr virus (EBV), urethra scraping for detecting high oncogenic risk HPV. Tumor tissue was sampled for PCR virus detection. Semi-quantitative analysis was used to evaluate the components of lymphocyte-plasmocyte and leukocyte infiltrates and cytopathic changes in tumor tissue. Results. There were positive correlations between cytopathic cell changes (koylocytosis and intranuclear inclusions, as manifestations of HPV) and the level of antiviral antibodies, the presence of viruses in the tumor, as well as with the components of the lymphoid-plasmocyte infiltrate. Negative correlations were found between the presence of papillomatosis and the above changes. Conclusion. Human papillomavirus is believed to be a trigger for the initiation of a tumor in young patients with a latent infection (CMV and EBV, HSV, HPV). Cytopathic changes (kylocytosis and intranuclear inclusions) were associated with the activity and morphological features of herpes-viral infections. Their degree varied depending on the stage of the process, but not on the anaplasia degree. Papillomatosis is associated with a more favorable course of the tumor process.

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About the authors

O. B Loran

RMACPE

Email: oleg_loran@gmail.com
Academician of the RAS, Dr.Med.Sci., Prof., Head of the Department of Urology and Surgical Andrology

L. A Sinyakova

RMACPE

Email: l.a.sinyakova@mail.ru
Dr.Med.Sci., Prof. at the Department of Urology and Surgical Andrology

L. V Gundorova

City Clinical Hospital №68, Moscow Health Department

Email: ludovik-213@mail.ru
Dr.Med.Sci., Head of the Department of Pathology and Autopsy

V. A Kosov

Komi Republican Oncology Center

Email: zinaidakosova@yandex.ru
Urologist-Oncologist, Leading Specialist

I. V Kosova

City Clinical Hospital №68, Moscow Health Department

Email: kosovainga@mail.ru
Ph.D., Urologist at the Department of Urology

I. E Pogodina

VRCH №2

Email: utk-irina@yandex.ru
Ph.D., Pathologist at the Pathology and Autopsy Department Cherepovets, Russia

D. N Kolbasov

City Clinical Hospital №68, Moscow Health Department

Email: urology68@rambler.ru
Ph.D., Urologist, the Department of Urology

References

  1. Мяндина Г.И., Пягай П.Э., Иткес А.В. и др. Детекция генома вируса папилломы человека типа 16 в клетках опухолей периферической крови пациентов, страдающих раком мочевого пузыря. Вестн. РУДН. Серия Медицина. 2003;5(24):29-32
  2. Андреева Ю.Ю. Морфологические и молекулярно-биологические факторы прогноза рака мочевого пузыря. Дисс. д.м.н., 2008
  3. Frank G., Zavalishina L., Andreeva Y.Y. Immunohistochemical study of urothelial carcinoma in patients with different tumor progression risk. Mod Pathol. 2006;19(Suppl 3):115.
  4. Moonen P.M., Bakkers J.M., Kiemeney L.A., Schalken J.A., Melchers W.J., Witjes J.A. Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer. Eur Urol. 2007;52:464-469.
  5. Головина Д.А., Ермилова В.Д., Хачатурян А.В., Чебан Н.Л., Матвеев В.Б., Волгарева Г.М. ВПЧ-статус рака мочевого пузыря, морфологические характеристики опухоли и клинические особенности заболевания. Онкоурология. 2014;1:35-38
  6. Griffiths T.R., Mellon J.K. Human papillomavirus and urological tumours: II. Role in bladder, prostate, renal and testicular cancer. BJU Int. 2000;85(2):211-217.
  7. Harald zur Hausen. Infections causing human cancer. 2006. Wiley-VCH Verlag GmbH and Co. KGA, Weinheim. Р. 517.
  8. Flamand L., Romerio F., Reitz M.S., Gallo R.C. CD4 promoter transactivation by human herpesvirus 6. J. Virol. 1998;72(11):8797-805.
  9. Epstein J.I., Reuter V.E., Amin M.B. Biopsy interpretation of the bladder. 2-nd Edition: Philadelphia: Lippincott Williams & Wilkins, 2004. 271 p.
  10. Taylor D.C., Bhagavan B.S., Larsen M.P., Cox J.A., Epstein J.I. Papillary urothelial hyperplasia. A precursor to papillary neoplasms. Am J. Surg Pathol. 1996;20:1481-1488.
  11. Chow N., Cairns P., Eisenberger C.F. et al. Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer. Int J. Cancer. 2000;89:514.
  12. Lopez-Beltran A., Escudero A.L., Carrasco-Aznar J.C., Vicioso-Recio L. Human papillomavirus infection and transitional cell carcinoma of the bladder: immunohistochemistry and in situ hybridization. Pathol Res Pract. 1996;192:154-159.
  13. Cecchini S., Cipparone I., Confortini M. Urethral cytology of cytobrush specimens. Acta Cytol. 1998;32:314-317.
  14. Savelieva E., Belair C.D., Newton M.A et al. 20q gain associates with innortalization:20ql3.2 amplification correlates with genome intstability in human uroepithelial cells. Oncogene. 1997;14:551-560.
  15. Park T.W., Fujiwara H., Wright T.C. Molecular biology of cervical cancer and its precursosrs. Cancer. 1995;76:1902-1913.
  16. Maloney K.E. et al. Oncogenic human papillomaviruses are rarely associated with squamous cell carcinoma of the bladder: evaluation by differential polymerase chain reaction. J. Urol. 1994;151:360-364.
  17. Aynaud O., Tranbaloc P., Orth G. Lack of evidence for a role of human papillomaviruses in transitional cell carcinoma of the bladder. J. Urol. 1998;159(1):86-89; discussion 90.
  18. LaRue H., Simoneau M. Human papillomavirus in transitional cell carcinoma of the urinary bladder. Clin Cancer Res. 1995;1:435-440.
  19. De Gaetani C. et al. Detection of HPV DNA in urinary bladder carcinoma by in situ hybridization. J. Clin Pathol. 1999;52:103-106.
  20. Ludwig M., Kochel H.G., Fischer C., Ringert R.H., Weidner W. Human papillomavirus in tissue of bladder and bladder carcinoma specimens: a preliminary study. Eur Urol. 1996;30:96-102.
  21. Piersma S.J. Immunosupressive tumpr microenvironment incervical cencer patients. Cancer Microenviron. 2011;4(3):361-375. Doi:10.1007/ s12307-011-0066-7.
  22. Barghi M.R., Hajimohammadmehdiarbab A., Moghaddam S.M., Kazemi B. Correlation between human papillomavirus infection and bladder transitional cell carcinoma. BMC Infect Dis. 2005;5:102.
  23. Eslami G., Golshani M., Rakhshon M. et al. The study on relation of Human Papillomavirus with bladder transitional cell carcinoma. Cancer Therapy. 2008;6:355-360.
  24. Guo C.C., Fine S.W., Epstein J.I. Noninvasive squamous lesions in the urinary bladder: a clinicopatholiguc analysis of 29 cases. A J. Surg Pathol. 2006;30(7):883-891.
  25. Aggarwal S., Arora VK., Gupta S. et al. Koilocytosis: correlations with high-risk HPV and its comparison on tissue sections and cytology, urothelial carcinoma. Diagn Cytopathol. 2009;37(3):174-177.
  26. Li N., Yang L., Zhang Y. et al. Human Papillomavirus Infection and Bladder Cancer Risk: A Meta-analysis. J. Infect Dis. 2011;204(2) :217- 223.
  27. Gutierrez J., Jimenez A., de Dios L.J., Soto M.J., Sorlozano A. Meta-analysis of studies analyzing the relationship between bladder cancer and infection by human papillomavirus. J. Urol. 2006;176:2474-2481.
  28. Wiwanitkit V. Urinary bladder carcinoma and human papilloma virus infection, an appraisal of risk. Asian Pac J. Cancer Prev. 2005;6:217-218.
  29. Shigehara K. et al. Etiologic role of Human papillomavirus infection in bladder cancer. Cancer. 2011:2067-2074.
  30. Munoz N. Human papillomavirus and cancer: the epidemiological evidence. J. Clin Virol. 2000;19:1-5.
  31. Hobbs C.G., Sterne J.A., Bailey M., Heyderman R.S., Birchall M.A., Thomas S.J. Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol. 2006;31:259-266.

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