Disorders of sexual differentiation in children: a critical look at open questions (part I)


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Abstract

Management of children with disorders of sexual differentiation (DSD) continues to cause questions and receive criticism. This review discusses some contradictions concerning the newly proposed terminology, nomenclature, and classification. Congenital adrenal hyperplasia (CAH) is the most common cause of DSD, and its management also remains controversial. Therefore, in this part of the article, we critically analyze available literature on gender identity, the need and timing of surgery in children with DSD and 46, XX karyotype.

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About the authors

N. D Shiryaev

Northern State Medical University of Minzdrav of Russia

Email: nikshir@yandex.ru
Dr.Med.Sci., Prof. a

I. M Kagantsov

Republican Children’s Clinical Hospital; Pitirim Sorokin Syktyvkar State University

Email: ilkagan@rambler.ru
Dr.Med.Sci., Prof. at the Department of Surgical Diseases, Pitirim Sorokin SSU; Head of the Department of Urology, Republican Children’s Clinical Hospital

V. V Sizonov

RostSMU of Minzdrav of Russia

Email: vsizonov@mail.ru
Dr.Med.Sci., Prof.

V. I Dubrov

Children’s Hospital #2, Minsk

Email: dubroff2000@mail.ru
Ph.D., Head of the Department of Urology

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