A role of fesoterodine in treatment of overactive bladder


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Abstract

The muscarinic receptors have been used as target in treatment of overactive bladder (OAB) for a long time. ^ese patients have complaints of urgency, increased urinary frequency and nocturia, sometimes with urinary incontinence (involuntary urine leakage which is associated with abrupt and strong desire to void). Fesoterodine is a prodrug that is structurally and functionally associated with tolterodine and it is the novel drug for OAB treatment. As a result of fesoterodine cleavage by non-specific esterase, the active metabolite 5-hydroxymethyl tolterodine (5-НМТ) is formed. Like other antimuscarinic drugs, fesoterodine allows to improve bladder storage function (reducing the frequency of urination) and urgency. For assessing an improvement of the quality of life after treatment by fesoterodine the KHQ questionnaire was used.

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About the authors

Yu. A Kupriyanov

Federal State Budgetary Educational Institution of Higher Education «A.I. Evdokimov Moscow State University of Medicine and Dentistry» of the Ministry of Healthcare of the Russian Federation; hospital n.a. S.I. Spasokukockogo

Email: Dr.kupriyanov@gmail.com
PhD in МєФієзі Sciences, assistent at department of urology; Urologist

G. R Kasyan

Federal State Budgetary Educational Institution of Higher Education «A.I. Evdokimov Moscow State University of Medicine and Dentistry» of the Ministry of Healthcare of the Russian Federation; hospital n.a. S.I. Spasokukockogo

Urologist; PhD in medical Sciences, professor at department of urology

D. Yu Pushkar

Federal State Budgetary Educational Institution of Higher Education «A.I. Evdokimov Moscow State University of Medicine and Dentistry» of the Ministry of Healthcare of the Russian Federation

PhD in medical Scieces, FEBU, professor, Corr. МєшЬєг of the RAS, Urologist General of Russia and Moscow, General scientific secretary Russian Society of Urology, Chairman department

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