Diagnosis and treatment of abacterial category III CP/CPPS, associated with herpes viruses


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Abstract

Introduction. The etiology of abacterial CP/CPPS (category III) has not been studied enough. Currently, there is no gold standard of diagnostic study and optimal treatment algorithm. Aim. The aim of our study was to study three human herpes viruses (HHV) in clinical samples from patients with inflammatory diseases of urogenital tract and to evaluate the efficiency of proposed treatment algorithm for abacterial CP/CPPS. Materials and methods. The biological samples from the urogenital tract (urethral swab, ejaculate and expressed prostatic secretions) from 101 patients with category III CP/CPPS were studied. Quantitative analysis of HHV DNA (CMV, EBV and HHV-6) was performed by PCR. Results. HHV DNA was detected in 38/101 patients (37.6%) in Group 1. Among the detected viral types, HHV-6 was the most common (52%). Analysis of biological samples form the three sources revealed that viral DNA was determined in urethral swab in concentration of3,703,900 copies/ ml. In Group 2, viral DNA was not detected in 63 patients. Evaluation of results of the standard treatment in HHV-negative patients (n=63) and antibiotic-free scheme, including the immunoregulatory drug Viferon®, in HHV-positive patients (n=38) showed that the number of HHV-positive samples after treatment decreased by 54.3%. In addition, severity of all symptoms according to NIH-CPSI scale significantly decreased in both groups (p<0.0001). There was an improvement in all clinical symptoms in Group 1 by 47.9%, especially for pain + urination (52%). It should be noted that a positive response to treatment, which was confirmed by the changes in total score of NIH-CPSI scale, was noted in all patients in Group 1. Conclusion. Detection of herpes viruses in the urogenital tract of patients with abacterial CP/CPPS suggests possible role of viral infections in its etiology. The comparative analysis of the results of standard treatment including antiviral, immunomodulatory and antioxidant drugs showed that the use of complex therapy without antibiotics allowed to eliminate or significantly reduce the concentration of viruses in urogenital tract, as well as significantly reduce the clinical manifestations of abacterial CP/CPPS.

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About the authors

V. V Evdokimov

N.F.Gamaleya Research Center for Epidemiology and Microbiology Ministry of Health of the Russian Federation

Email: vladimir.evdokimov@gmail.com
researcher

V. P Kovalyk

N.F.Gamaleya Research Center for Epidemiology and Microbiology Ministry of Health of the Russian Federation

Email: kovalyk@mail.ru
Ph.D., associate professor at the Department of Dermatology, Venerology and Cosmetology

V. V Malinovskaya

N.F.Gamaleya Research Center for Epidemiology and Microbiology Ministry of Health of the Russian Federation

Email: info@viferon.su
doctor of biological sciences, professor, head of the Laboratory of ontogenesis and correction of interferon system

A. N Shuvalov

N.F.Gamaleya Research Center for Epidemiology and Microbiology Ministry of Health of the Russian Federation

Email: shuvalovan33@mail.ru
Ph.D., researcher at the Laboratory of ontogenesis and correction of interferon system

A. A Kushch

N.F.Gamaleya Research Center for Epidemiology and Microbiology Ministry of Health of the Russian Federation

Email: vitallku@mail.ru
doctor of biological sciences, professor, head of the Laboratory of Cell Engineering

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