Fatty acid-binding protein in the serum and sperm


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Аннотация

Introduction. a composition of seminal plasma reflects a state of reproductive organs that are involved in sperm production. Aim: to study a concentration of fatty acid-binding protein (FABP) in blood serum and sperm samples with normal and altered characteristics. Materials and methods: a total of 82 men with mean age of 33.1+4.7 years old who were examined to clarify the cause of infertility were included in the study. The main group (n=21) consisted of men with oligozoospermia, while control group (n=33) consisted of healthy men with normal sperm analysis. In addition, patients with high viscosity of sperm were included in the comparison group (n=28). There were no changes in complete blood count and biochemical blood panel in all participants. The content of FABP in blood serum and seminal plasma was determined. Results: the average content of FABP in seminal plasma was 1.347+0.26 ng/ml and exceeded the serum concentration of this compound (p<0.000001), which was 0.305+0.193 ng/ml. The concentration in seminal plasma did not depend on its serum concentration (R=0,068194), as well as the sperm volume and viscosity, but it was correlated with sperm concentration (R=0,66387). The concentration of FABP in seminal plasma was highest in the control group (1.47+0.33 ng / ml) and it was higher compared to the main group (1.22+0.09 ng/ml; p=0.000057) and the comparison group (1.29+0.19 ng/ml; p=0.010822). There was no difference between groups in serum concentration of FABP (p=0.9814). Conclusion: the obtained data suggest that a reduced level of FABP in seminal plasma can be considered as unfavorable criterion indicating a reduced fertility.

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Авторлар туралы

D. Sosnin

Federal State Budgetary Educational Institution of Higher Education “Academician Ye. A. Vagner Perm State Medical University” of the Ministry of Healthcare of the Russian Federation

Email: sosnin_dm@mail.ru
MD, professor at the Department of the Clinical and Laboratory Diagnostics

K. Gal’kovich

Medical Canter OOO «MedGarant»

Ph.D., urologist

N. Zubareva

Federal State Budgetary Educational Institution of Higher Education “Academician Ye. A. Vagner Perm State Medical University” of the Ministry of Healthcare of the Russian Federation

MD, professor at the Department of General Surgery № 1

A. Krivtsov

FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for the Oversight of Consumer Protection and Welfare

Ph.D., Chief of the Laboratory of Immunogenetics Laboratory

N. Pozdin

FSEIHE «Perm National Research Polytechnic University» Russian Federation

student of the Faculty of Applied Mathematics and Mechanics

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