Reflux nephropathy in children: pathogenesis and prognosis. Part 1


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Abstract

The purpose of this review is to analyze the modern literature about renal damage caused by vesicoureteral reflux (VUR). VUR is the most common urodynamic pathology in children and reflux nephropathy (RN), as its main complication, ranks first among the causes of chronic kidney disease (CKD). The risk factors for the appearance and progression of RN are presented in the first part of the review. In the framework of this issue, the main methods of treatment of VUR and associated urinary tract infection are described. The possibilities of conservative and surgical methods for the elimination of reflux for prevention of RN and prognosis of its course are considered. The main morphological aspects of RN formation are described.

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About the authors

O. L Morozova

Sechenov First Moscow State Medical University

Email: morozova_ol@list.ru
Doctor of Medical Sciences, professor, Department of Pathophysiology

D. Y Lakomova

Saratov State Medical University n. a. V.I. Razumovsky

Email: dlmedic@mail.ru
Ph.D., associate professor at the Department of Pediatric Surgery

N. B Zakharova

Saratov State Medical University n. a. V.I. Razumovsky

Email: lipidgormon@mail.ru
Doctor of Medical Sciences, professor, Department of clinical and laboratory diagnostics

L. D Maltseva

Sechenov First Moscow State Medical University

Email: lamapost@mail.ru
Ph.D., associate professor at the Department of Pathophysiology

Z. Sh Manasova

Sechenov First Moscow State Medical University

Email: butri78@mail.ru
Ph.D., associate professor at the Department of Pathophysiology

D. A Morozov

Sechenov First Moscow State Medical University

Email: damorozov@list.ru
MD, professor at the Department of Pediatric Surgery, Urology and Andrology

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