Whole-body PET/CT scan with 18F-FDG glucose for a clinical assessment of renal parenchyma viability


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Abstract

Aim: to perform a comparative analysis ofthe results of morphofunctional and morphoanatomical studies for the clinical assessment of the viability of the renal parenchyma. Materials and methods. Based on a random sampling method, the results of whole-body PET/CT scan with 18F-FDG glucose in 134 patients with various non-urological disorders were analyzed. However, 13.3% of the participants had concomitant chronic kidney diseases without exacerbation. At the same time, the morphoIogicaI and anatomicaI manifestations of chronic kidney disease were studied in 32 patients of the same age and sex in order to evaluate the severity of structural changes in nephron. Results. It was found that among individuals undergone to whole -body PET/CT scan with 18F-FDG glucose for various diseases without a urological history and patients with chronic kidney disease, the parenchyma tropism to energy-intensive labeled glucose molecules had certain differences that correlated with morphoanatomical manifestations of structural changes in the nephron in chronic kidney disease. Conclusions. The modern morphofunctional PET/CT study of the whole-body viability with 18F-FDG glucose, including the kidneys, is an advanced diagnostic tool that may supplement the results of morphoanatomical studies and monitor the efficiency of treatment.

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About the authors

B. A Berdichevskyy

FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia

Email: doktor_bba@maii.ru
Ph.D., MD, professor at the Department of Oncology with a course of Urology Tyumen, Russia

V. B Berdichevskyy

FGBOU VO Tyumen State Medical University of the Ministry of Health of Russia

Ph.D., MD, associate professor at the Department of Oncology with a course of Urology Tyumen, Russia

A. G Bichenova

RadiologicaI Center of Tyumen Regional Oncological Dispensary (Multidisciplinary Clinical Medical Center "Medical City")

pathologist at the Pathology bureau Tyumen, Russia

D. A Barashin

RadiologicaI Center of Tyumen Regional Oncological Dispensary (Multidisciplinary Clinical Medical Center "Medical City")

Ph.D. radiologist Tyumen, Russia

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