The role of male factor in pregnancy loss


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Abstract

Currently fertility specialists pay close attention to miscarriage. Spontaneous abortion and recurrent pregnancy loss in an early period of gestation are a frequent complication of pregnancy. Etiology of miscarriage includes genetic abnormalities, immunological disorders, endocrine abnormalities, infections and lifestyle factors. About 40% of cases of pregnancy losses remain unexplained. The role of male factor in miscarriages is considered in the review. The influence of advanced paternal ages, sperm DNA fragmentation, chromosomal abnormalities on pregnancy loss in natural conception or by assisted reproductive technique are described.

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About the authors

M. N Korshunov

Central Medical Academy Administration of the President of Russian Federation

Email: m_korshunov@bk.ru
Ph.D., доцент Department of Urology Moscow, Russia

E. S Korshunova

Central Medical Academy Administration of the President of Russian Federation

Email: e_korshunova@mail.ru
Ph.D., доцент Department of Urology Moscow, Russia

Yu. V Kastrikin

Research Institute of Urology and Interventional Radiology N.A. Lopatkin - branch of FSBI NMRRC of the Ministry of Health care of Russia; Pirogov Russian National Research Medical University

Email: dr.kastrikin@mail.ru
junior researcher at the Department of Andrology and Reproduction Moscow, Russia

E. A Efremov

Pirogov Russian National Research Medical University; International Andrological Center

Email: konfandrology@rambler.ru
E.A. - Ph.D., MD, professor at the Department of Urology, Andrology and Oncourology Moscow, Russia

S. P Darenkov

Central Medical Academy Administration of the President of Russian Federation

Email: darenkov@list.ru
Ph.D., MD, Head of the Department of Urology Moscow, Russia

References

  1. Лебедев Г.С., Голубев Н.А., Шадеркин И.А., Шадеркина В.А., Аполихин О.И., Сивков А.В., Комарова В.А. Мужское бесплодие в Российской Федерации: статистические данные за 2000-2018 гг. Экспериментальная и клиническая урология 2019;(4):4-12
  2. Kaser D. The status of genetic screening in recurrent pregnancy loss. Obstet Gynecol Clin North Am. 2018;45(1):143-154. https://doi.org/10.1016/j. ogc.2017.10.007
  3. Li Y.H., Marren A. Recurrent pregnancy loss. Australian journal of general practice. Aust J Gen Pract. 2018;47 (7) :432-436. https://doi.org/10.31128/AJGP-01-18-4459
  4. Larsen E.C., Christiansen O.B., Kolte A.M., Macklon N. New insights into mechanisms behind miscarriage. BMC Med. 2013;26(11):154. https://doi.org/10.1186/1741-7015-11-154
  5. Alegn'a-Torres J.A., Baccarelli A., Bollati V. Epigenetics and lifestyle. Epigenomics. 2011; 3(3): 267-277. https://doi.org/10.2217/epi.11.22
  6. Dashwood R.H., Ho E. Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol. 2007;17(5):363-369. https://doi.org/10.1016/j.semcancer.2007.04.001
  7. Prine Linda W., Macnaughton Honor. Office Management of Early Pregnancy Loss. Am Fam Physician. 2011 ;84( 1):75-82. PMID: 21766758.
  8. Santi D., Spaggiari G., Simoni M. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management - meta-analyses. RBMO. 2018;37(3):315-326. https://doi.org/10.1016/j.rbmo.2018.06.023
  9. Simon L., Zini A., Dyachenko A., Ciampi A., Carrell D.T. A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome. Asian Journal of Andrology. 2017;19:80-90. https://doi.org/10.4103/1008-682X
  10. Sakkas D., Alvares J.G. Sperm DNA fragmentation: mechanism of origin, impact on reproductive outcome and analysis. Fertili. Steril. 2010;93(4):1027-1036. https://doi.org/10.1016/j.fertnstert.2009.10.046
  11. Johnson S.L., Dunleavy J., Gemmell N.J., Nakagawa S. Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis. Ageing Res Rev. 2015;19:22-33. https://doi.org/10.1016/j.arr.2014.10.007
  12. Kleinhaus K., Perrin M., Friedlander Y., Paltiel O., Malaspina D., Harlap S. Paternal age and spontaneous abortion. Obstet Gynecol. 2006;108(2):369-377. https://doi.org/10.1097/01.A0G.0000224606.26514.3a
  13. Slama R., Bouyer J., Windham G., Fenster L., Werwatz A., Shanna H. Swan. Influence of paternal age on the risk of spontaneous abortion. Am J Epidemiol. 2005;161(9):816-823. https://doi.org/10.1093/aje/kwi097
  14. Selvin S., Garfinkel J. Paternal age, maternal age and birth order and the risk of a fetal loss. Hum Biol. 1976;48(1):223-230. PMID: 1254285.
  15. Рогозин Д.С. Мужская фертильность: обзор литературы января - марта 2020 года. Вестник урологии. 2020;8(2):93-98. https://doi.org/10.21886/2308-6424-2020-8-2-93-98
  16. Martha Luna., Elissa Finkler B.S., Jason Barritt, Natan Bar-Chama, Benjamin Sandler, Alan B. Copperman, Lawrence Grunfeld. Paternal age and assisted reproductive technology outcome in ovum recipients. Fertil Steril. 2009;92(5): 1772-1775. https://doi.org/10.1016/j.fertnstert.2009.05.036
  17. Nadia A. du Fosse, Marie-Louise P. van der Hoorn, Jan M.M. van Lith, Saskia le Cessie, Eileen E.L.O. Lashley. Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis. Hum Reprod Update. 2020;26(5) :650-669. https://doi.org/10.1093/humupd/dmaa010
  18. Talebi A.R., Vahidi S., Aflatoonian A., Ghasemi N., Ghasemzadeh J., Firoozabadi R.D., Moein M.R. Cytochemical evaluation of sperm chromatin and DNA integrity in couples with unexplained recurrent spontaneous abortions. Andrologia. 2012;44(Suppl. 1):462-470. https://doi.org/10.1111/j.1439-0272.2011.01206.x
  19. Lihong Zhang, Leiguang Wang, Xingqi Zhang, Guanzhao Xu, Wei Zhang, Kehua Wang, Qiuju Wang, Yi Qiu, Juan Li, Ling Gai. Sperm chromatin integrity may predict future fertility for unexplained recurrent spontaneous abortion patients. Int J Androl. 2012;35(5):752-757. https://doi.org/10.1111/j.1365-2605.2012.01276.x
  20. James M. Hotaling, James F. Smith, M.S., Mitchell Rosen, Charles H. Muller, Thomas J. Walsh, M.S. The relationship between isolated teratozoospermia and clinical pregnancy after in vitro fertilization with or without intracytoplasmic sperm injection: a systematic review and metaanalysis. Fertil Steril. 2011;95(3): 1141-1145.https://doi.org/10.1016/j. fertnstert.2010.09.029
  21. Sonia Brahem, Meriem Mehdi, Hanene Landolsi, Soumaya Mougou, Hatem Elghezal, Ali Saad. Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss. Urology. 2011 ;78(4) :792-796. https://doi.org/10.1016/j.urology.2011.05.049
  22. Puscheck E.E., Jeyendran R.S. The impact of male factor on recurrent pregnancy loss. Curr Opin Obstet Gynecol. 2007;19(3):222-228. https://doi.org/10.1097/GC0.0b013e32813e3ff0
  23. Bronson R. Role of spermatozoa in the etiology of miscarriage. Fertility and sterility. 2016; 105( 1):47-48. http://dx.doi.org/10.1016/j.fertnstert.2015.10.016
  24. Гамидов С.И., Овчинников Р.И., Попова А.Ю., Голубева О.Н., Ушакова И.В. Роль мужчины в привычном невынашивании беременности у супруги. Урология. 2016;1:35-43
  25. Camille Esquerre-Lamare, Marie Walschaerts, Lucie Chansel Debordeaux, Jessika Moreau, Florence Bretelle, Frangois Isus, Gilles Karsenty, Laetitia Monteil, Jeanne Perrin, Aline Papaxanthos-Roche, Louis Bujan. Sperm aneuploidy and DNA fragmentation in unexplained recurrent pregnancy loss: a multicenter case-control study. Basic Clin Androl. 2018;28:4. https://doi.org/10.1186/s12610-018-0070-6
  26. Simon L., Brunborg G., Stevenson M., Lutton D., McManus J., Sheena E.M. Lewis. Clinical significance of sperm DNA damage in assisted reproduction outcome. 2010;25(7):1594-1608. https://doi.org/10.1093/humrep/deq103
  27. Garrido N., Meseguer M., Simon C., Pellicer A., Remohi J. Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. Asian J Androl. 2004;6(1):59-65. PMID: 15064836.
  28. Agarwal A., Cho C.L., Esteves S.C. Should we evaluate and treat sperm DNA fragmentation? Curr Opin Obstet Gynecol. 2016;28(3): 164-171. https://doi.org/10.1097/GC0.0000000000000271
  29. Twigg J.P., Irvine D.S., Aitken R.J. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod. 1998; 13(7): 1864-1871. https://doi.org/10.1093/humrep/13.7.1864
  30. Genesca A., Caballin M.R., Miro R., Benet J., Germa J.R., Egozcue J. Repair of human sperm chromosome aberrations in the hamster egg. Hum Genet. 1992;89(2):181-186. https://doi.org/10.1007/BF00217120
  31. Коршунов М.Н., Коршунова Е.С., Даренков С.П. Прогностическая ценность показателя ДНК-фрагментации сперматозоидов в успехе программ вспомогательных репродуктивных технологий. Эмпирическая антиоксидантная терапия в коррекции ДНК-фрагментации на фоне патологического окислительного стресса эякулята. Экспериментальная и клиническая урология. 2017;(3):70-77
  32. Dana B. McQueen, John Zhang, Jared C. Robins. Sperm DNA fragmentation and recurrent pregnancy loss: a systematic review and metaanalysis. Fertil Steril. 2019;112(1):54-60.e3. https://doi.org/10.1016/j. fertnstert.2019.03.003
  33. Gihan M., Bareh M.D., Ph.D., Ethan Jacoby B.A., Peter Binkley B.S., Tien-cheng “Arthur” Chang Ph.D. Robert S. Schenken M.D., Randal D., Robinson M.D. Sperm deoxyribonucleic acid fragmentation assessment in normozoospermic male partners of couples with unexplained recurrent pregnancy loss: a prospective study. Fertil Steril. 2016;105(2):329-336.e1. https://doi.org/10.1016/jiertnstert.2015.10.033
  34. CarrellD.T., Liu L., Peterson C.M., Jones K.P., Hatasaka H.H., Erickson L., Campbell B. Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss. Arch Androl. 2003;49(1):49-55. https://doi.org/10.1080/01485010290099390
  35. Evenson D., Wixon R. Meta-analysis of sperm DNA fragmentation using the sperm chromatin structure assay. Reproductive biomedicine online. 2006;12(4):466-472. https://doi.org/10.1016/s1472-6483(10)62000-7
  36. Zini A., Boman J.M., Belzile E., Ciampi A. Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis. Hum Reprod. 2008;23(12):2663-2668. https://doi.org/10.1093/humrep/den321
  37. Zhao J., Zhang Q, Wang Y., Li Y. Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. Fertil Steril. 2014;102(4):998-1005.e8. https://doi.org/10.1016/j.fertnstert.2014.06.033
  38. Aida Casanovas, Jordi Ribas-Maynou, Sandra Lara-Cerrillo, Ana Raquel Jimenez-Macedo, Olga Hortal, Jordi Benet, Joan Carrera, Agusti'n Garcia-Peiro. Double-stranded sperm DNA damage is a cause of delay in embryo development and can impair implantation rates. Fertil Steril. 2019;111(4):699-707. https://doi.org/10.1016/j.fertnstert.2018.11.035
  39. Pons I., Cercas R., Villas C., Brana C., Fernandez-Shaw S. One abstinence day decreases sperm DNA fragmentation in 90% of selected patients. J Assist Reprod Genet 2013;30(9):1211-1218. https://doi.org/10.1007/s10815-013-0089-8
  40. Боровец С.Ю., Рыбалов М.А., Горбачев А.Г., Аль-Шукри С.Х., Левина А.В. Отдаленные результаты лечения препаратом Простатилен® АЦ больных хроническим абактериальным простатитом с повышенной степенью фрагментации ДНК сперматозоидов. Андрология и генитальная хирургия. 2018;19(2):52-56. https://doi.org/10.17650/2070-9781-201819-2-52-57)

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