Ultrastructural features of histological variants of renal cell carcinoma


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article presents the main electron microscopic signs of the main histological variants of renal cell carcinoma. The ultrastructural profiles of rare forms of renal cell carcinoma included in the latest International Histological Classification of Kidney Tumors (WHO, 2016) are considered.

Full Text

Restricted Access

About the authors

Y. I Osmanov

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: osmanovyouseef@yandex.ru
MD, professor of Department of Pathology named after A.I. Strukov Moscow, Russia

E. A Kogan

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: koganevg@gmail.com
MD, professor, Head of the Department of Pathology named after A.I. Strukov Moscow, Russia

Z. K Gadzhieva

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: zgadzhieva@ooorou.ru
MD, Head of the Department for the Analysis of Personnel Policy, Educational Programs and Scientific Research of the National Medical Research Center on the profile «Urology» Moscow, Russia

D. D Prochenko

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: chief@medprint.ru
Ph.D., assistant professor of Department of Pathology named after A.I. Strukov Moscow, Russia

References

  1. Pradhan D., Kakkar N., Bal A., Singh S.K., Joshi K. Subtyping of renal cell tumours; contribution of ancillary techniques. Diagn Pathol. 2009;4:21. doi: 10.1186/1746-1596-4-21.
  2. El-Kott A.F., Ismaeil M.F., El-Moneim M.M. et al. Histogenesis of human renal cell carcinoma by using electron microscopy and immunohistochemical techniques.Int Urol Nephrol. 2005; 37 (3): 439-45. doi: 10.1007/s11255-004-6103-4.
  3. Ma J., Zhou X.J., Huang W.B., Zhou H.B. et al. Clinicopathologic study of renal cell carcinoma with rhabdoid features. Zhonghua Bing Li Xue Za Zhi. 2007; 36 (3): 166-70. Doi: 10.3760.
  4. Tickoo S.K., Lee M.W., Eble J.N. Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. Am J Surg Pathol. 2000; 24 (9): 1247-56. doi: 10.1097/00000478-200009000-00008.
  5. Cheng L., Bostwick D.G. Urologic Surgical pathology. 2014; 86-88. ISBN: 978-1-4557-4327-8.
  6. Shi S.S., Shen Q., Xia Q.Y. et al. Clear cell papillary renal cell carcinoma: a clinicopathological study emphasizing ultrastructural features and cytogenetic heterogeneity.Int J Clin Exp Pathol. 2013 Nov 15;6(12):2936-42.
  7. Williamson S.R., Hornick J.L., Eble J.N. et al. Renal cell carcinoma with angioleiomyoma-like stroma and clear cell papillary renal cell carcinoma: exploring SDHB protein immunohistochemistry and the relationship to tuberous sclerosis complex. Hum Pathol. 2018;75:10-15. doi: 10.1016/j.humpath.2017.11.013.
  8. Heidarian A., Banihashemi A., Wieczorek R. et al. Synchronous Chromophobe Renal Cell Carcinoma and Papillary Renal Cell Carcinoma: Supportive Evidence for the Cancer Stem Cell Hypothesis. American Journal of Clinical Pathology. 2018;150(1):S52.
  9. Hes O., Brunelli M., Michal M. et al. Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases. Ann Diagn Pathol. 2006;10(3):133-139. doi: 10.1016/j.anndiagpath.2005.12.002.
  10. Krishnan B., Truong L.D. Renal epithelial neoplasms: the diagnostic implications of electron microscopic study in 55 cases. Hum Pathol. 2002;33(1):68-79. doi: 10.1053/hupa.2002.30210.
  11. Danbara N., Shikata N., Kawamura H. et al. Eosinophilic cytoplasmic inclusions in papillary renal cell carcinoma. Med Mol Morphol 38,262(2005). doi: 10.1007/s00795-005-0286-3.
  12. Cohen R.J., Weinstein S., Robertson T. et al. Variant Chromophobe Renal Cell Carcinoma. Arch Pathol Lab Med. 2000;124:904-906. doi: 10.5858/2000-124-0904-VCRCC.
  13. Johnson N.B., Johnson M.M., Selig M.K. et al. Use of Electron Microscopy in Core Biopsy Diagnosis of Oncocytic Renal Tumors. J Ultrastructural Pathology. 2010;34(4):189-194. doi: 10.3109/01913121003725713.
  14. Liu J., Fanning C.V. Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens? A study of conventional smears in conjunction with ancillary studies. Cancer. 2001;93(6):390-397. doi: 10.1002/cncr.10141.
  15. Yusenko M.V. Molecular pathology of chromophobe renal cell carcinoma: A review.International Journal of Urology. 2010;17:592-601. doi: 10.1111/j.1442-2042.2010.02558.x.
  16. Kuroda N., Toi M., Hiroi M. et al. Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects. J Histology and Histopathology. 2003;18:165-71. doi: 10.14670/HH-18.165.
  17. Pusiol T., Franceschetti I., Scialpi M. et al. Electron microscopy: the gold standard in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma. Anal Quant Cytol Histol. 2010;32(1):58-60.
  18. Skinnider B.F., Jones E.C. Renal oncocytoma and chromophobe renal cell carcinoma. A comparison of colloidal iron staining and electron microscopy. Am J Clin Pathol. 1999;111(6):796-803. doi: 10.1093/ajcp/111.6.796.
  19. Li M., Vuolo M.A., Weidenheim K.M. et al. Collecting-duct carcinoma of the kidney with prominent signet ring cell features. Mod Pathol. 2001 Jun;14(6):623-628. doi: 10.1038/modpathol.3880361.
  20. Mardi K., Biswas B. Collecting-duct carcinoma ofthe kidney with prominent signet ring cell features. J Clinical Cancer investigation. 2012;1(3):170-72.
  21. Elliott, Bruner E. Renal Medullary Carcinoma. Archives of Pathology & Laboratory Medicine. 2019;143(12):1556-1561. doi: 10.5858/arpa.2017-0492-RS.
  22. Wartchow E.P., Trost B.A., Tucker J.A. et al. Renal medullary carcinoma: ultrastructural studies may benefit diagnosis. Ultrastruct Pathol. 2008;32(6):252-256. doi: 10.1080/01913120802591875.
  23. Yang X., Sugimura J., Tretiakova M. et al. Gene Expression Profiling of Renal Medullary Carcinoma. J Cancer. 2004;100:976-985. doi: 10.1002/cncr.20049.
  24. Krishnan B., Truong L.D. Renal epithelial neoplasms: the diagnostic implications of electron microscopic study in 55 cases. Hum Pathol. 2002;33(1):68-79. doi: 10.1053/hupa.2002.30210.
  25. Macke R.A., Hussain M.B., Imray T.J et al. Osteogenic and sarcomatoid differentiation of a renal cell carcinoma. Cancer. 1985;56(10):2452-57. doi: 10.1002/1097-0142(19851115)56:10<2452::aid-cncr2820561021>3.0.co;2-c.
  26. Talento R., Hewan-Love K., Yin M. Evaluation of Morphologically Unclassified Renal Cell Carcinoma with Electron Microscopy and Novel Renal Markers: Implications for Tumor Reclassification. Ultrastruct Pathol. 2013;37(1):70-76. doi: 10.3109/01913123.2012.739595.
  27. Banerjee I., Yadav S., Tomar V. et al. Tubulocystic Renal Cell Carcinoma: A Great Imitator. Rev Urol. 2016;18(2):118-21. doi: 10.3909/riu0692.
  28. Bhullar J.S., Bindroo S., Varshney N. et al. Tubulocystic Renal Cell Carcinoma: A Rare Renal Tumor. J Kidney Cancer VHL. 2014;1(5):56-62. doi: 10.15586/jkcvhl.2014.13.
  29. Alexiev B.A., Burke A.P., Drachenberg C.B. et al. Mucinous tubular and spindle cell carcinoma of the kidney with prominent papillary component, a non-classic morphologic variant. A histologic, immunohistochemical, electron microscopic and fluorescence in situ hybridization study. Pathol Res Pract. 2014 Jul; 210(7):454-458. doi: 10.1016/j.prp.2014.03.002.
  30. Jung S.J., Yoon H.K., Chung J. et al. Mucinous tubular and spindle cell carcinoma of the kidney with neuroendocrine differentiation. Am J Clin Pathol 2006;125:99-104.
  31. Kuroda N., Nakamura S., Miyazaki E. et al. Low-grade tubular-mucinous renal neoplasm with neuroendocrine differentiation: a histological, immunohistochemical and ultrastructural study. Pathol Int. 2004;54(3):201-207. doi: 10.1111/j.1440-1827.2004.01608.x.
  32. Trpkov K., Hes O., Bonert M. et al. Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. Am J Surg Pathol. 2016;40(1):60-71. doi: 10.1097/PAS.0000000000000508.
  33. (Смирнова Е.А., Бежанова С.Д., Козлов Н.А. и др. Почечно-клеточный рак, ассоциированный с Хр11-транслокацией гена TFE3. Архив патологии. 2018;1:58-62. doi: 10.17116/patol201880158-62.
  34. Meyer P.N., Clark J., Flanigan R.C. et al. Xp11.2 Translocation Renal Cell Carcinoma With Very Aggressive Course in Five Adults. Am J Clin Pathol. 2007; 128:70-79. doi: 10.1309/LR5G1VMXPY3G0CUK.
  35. Xia Q.Y., Wang X.T., Zhan X.M. et al. Xp11 Translocation Renal Cell Carcinomas (RCCs) With RBM10-TFE3 Gene Fusion Demonstrating Melanotic Features and Overlapping Morphology With t(6;11) RCC: Interest and Diagnostic Pitfall in Detecting a Paracentric Inversion of TFE3. Am J Surg Pathol. 2017;41(5):663-676. doi: 10.1097/PAS.0000000000000837.
  36. Bernstein J., Evan A., Gardner K. Epithelial Hyperplasia in Human Polycystic Kidney Diseases. American Journal of Pathology. 1987;129(1):92-101.
  37. Kuroda N, Tamura M, Taguchi T et al. Sarcomatoid acquired cystic disease-associated renal cell carcinoma. J Histology and Histopathology. 2008;23(11):1327-1331. doi: 10.14670/HH-23.1327.
  38. Mickisch O., Bommer J., Bachmann S. et al. Multicystic Transformation of Kidneys in Chronic Renal Failure. J Nephron. 1984;38:93-99. doi: 10.1159/000183288.
  39. Housley S.L., Lindsay R.S., Young B. et al. Renal carcinoma with giant mitochondria associated with germline mutation and somatic loss of the succinate dehydrogenase B gene. Histopathology. 2010;56(3):405-408. doi: 10.1111/j.1365-2559.2010.03482.x.
  40. Tsai.T,Lee W. Succinate Dehydrogenase-Deficient Renal Cell Carcinoma. Archives of Pathology & Laboratory Medicine. 2019;1(143):643-647. doi: 10.5858/arpa.2018-0024-RS.
  41. Tong W., Sourbier C., Kovtunovych G. et al. The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels. J Cancer Cell. 2011;20(3):315-327. doi: 10.1016/j.ccr.2011.07.018.
  42. Yang Y., Valera V.A., Padilla-Nash H.M. et al. UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genet Cytogenet. 2010;196(1):45-55. doi: 10.1016/j.cancergencyto.2009.08.018.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2022 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies