Male reproductive health and COVID-19


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Abstract

The SARS-CoV-2 pandemic has brought serious economic and social problems worldwide'. Due to its medical consequences, it is of importance to study the mechanisms of the disease and new therapeutic interventions, as well as rehabilitation processes. Despite the fact that the genome of the new coronavirus has been sequenced and studied, clinical and epidemiological data are constantly updated and analyzed, and exact pathogenesis has not yet been understood. At the same time, domestic and foreign studies suggest that the virus is an agent that affects not only the lungs, vascular wall, hemostasis, but also the reproductive system. The aim of the review is to summarize the current knowledge about novel SARS-CoV-2, including its pathophysiology and potential impact on male reproductive function.

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About the authors

N. A Kurashova

Federal State Public Scientific Institution «Scientific Centre for Family Health and Human Reproduction Problems»

Email: nakurashova@yandex.ru
PhD, ScD, senior researcher of the Laboratory of Pathophysiology

B. G Dashiev

Federal State Public Scientific Institution «Scientific Centre for Family Health and Human Reproduction Problems»

Email: bairdashiev@mail.ru
PhD, junior researcher of the Laboratory of Pathophysiology of Reproduction

S. I Kolesnikov

Federal State Public Scientific Institution «Scientific Centre for Family Health and Human Reproduction Problems»

Email: iphr@sbamsr.irk.ru
Member of the RAS, PhD, MD, professor

L. I Kolesnikova

Federal State Public Scientific Institution «Scientific Centre for Family Health and Human Reproduction Problems»

Email: iphr@sbamsr.irk.ru
Member of the RAS, PhD, MD, professor, scientific director

References

  1. Овчинников Р.И., Гамидов С.И., Попова А.Ю., Ижбаев С.Х. Мужское бесплодие: до и после эпохи коронавируса SARS-Cov-2 Медицинский совет. 2020;13:179-187
  2. Kolesnikova L.I., Kurashova N.A., Bairova T.A., Dolgikh M.I., Ershova O.A., Korytov L.I., Koroleva N.V., Dashiev B.G. Role of glutathione-S-transferase family genes in male infertility Bulletin of Experimental Biology and Medicine. 2017;163(5):643-645. doi: 10.1007/s10517-017-3869-9
  3. Kolesnikova L.I., Kurashova N.A., Bairova T.A., Dolgikh M.I., Ershova O.A., Natyaganova L.V., Koroleva N.V., Dashiev B.G., Gutnik I.N. Features of lipoperoxidation, antioxidant defense, and thiol/disulfide system in the pathogenesis of infertility in males, carriers of nonfunctional variants of GSTT1 and GSTM1 gene polymorphisms Bulletin of Experimental Biology and Medicine. 2017;163(3):378-380. doi: 10.1007/s10517-017-3808-9
  4. Загарских Е.Ю., Лабыгина А.В., Курашова Н.А. Опыт лечения нормогонадотропного бесплодия у мужчин. Урология. 2014;5:87-89
  5. Kolesnikova L.I., Kolesnikov S.I., Kurashova N.A., Osadchuk L.V., Osadchuk A.V., Dolgikh M.I., Dashiev B.G., Shantanova L.N. Reproductive health and peculiarities of lipid peroxidation-antioxidant defense system in men of the main ethnic groups of the Baikal region Bulletin of Experimental Biology and Medicine. 2015;160(1):32-34. doi: 10.1007/s10517-015-3091-6
  6. Курашова Н.А. Оценка репродуктивного потенциала мужского населения Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук. 2014; 96(2): 104-109
  7. Адамян Л.В., Елагин В.В., Киселева Ю.Ю., Вечорко В.И., Степанян А.А., Дашко А.А., Дорошенко Д.А. Влияние Covid-19 и других вирусных инфекций на мужскую фертильность (обзор литературы). Проблемы репродукции. 2020;26(6):77-82. Doi.org/10.17116/repro20202606177
  8. Ефремов Е.А., Касатонова Е.В., Мельник Я.И., Никушина А.А. Влияние covid-19 на мужскую фертильность. Что уже известно? Урология 2020;4:104-110. doi: 10.18565/urology.2020.4.104-110.
  9. Адамян Л.В., Киселева Ю.Ю., Елагин В.В., Вечорко В.И., Степанян А.А.,Азнаурова Я.Б., Дашко А.А. Covid-19 и репродуктивное здоровье мужчин (обзор литературы). Проблемы репродукции. 2020;26(5):17-21. Doi.org/10.17116/ repro20202605117
  10. Колесникова Л.И., Курашова Н.А., Долгих М.И., Неронова Н.А., Кириленко Е.А. Состояние процессов липопероксидации у мужчин с хронической монотрихомонадной инфекцией на фоне приема триэтаноламмониевой соли 2-метилфеноксиуксусной кислоты. Клиническая лабораторная диагностика. 2015;60(1):16-19
  11. Youssef K., Abdelhak K. Male genital damage in Covid-19 patients: Are available data relevant? Asian J Urol. 2020;21. Doi: 10.1016/j. ajur.2020.06.005.
  12. Anifandis G., Messini C.I., Daponte A., Messinis I.E. Covid-19 and fertility: a virtual reality. Reprod Biomed Online. 2020;41 (2): 157-159. doi: 10.1016/j.rbmo.2020.05.001.
  13. Yangcheng Yao, Xiaoqiong Yuan, Linjing Wu, Na Guo, Li Yin, Yufeng Li Covid-19 and male reproduction: Current research and unknown factors First published: 11 January 2021. Doi.org/10.1111/andr.12970.
  14. Esteves S.C., Lombardo F., Garrido N., Alvarez J., Zini A., Colpi G.M., Kirkman-Brown J., Lewis S.E.M., Bjorndahl L., Majzoub A., Cho C.L., Vendeira P., Hallak J., Amar E., Cocuzza M., Bento F.C., Figueira R.C., Sciorio R., Laursen R.J., Metwalley A.M., Jindal S.K., Parekattil S., Ramasamy R., Alviggi C., Humaidan P., Yovich J.L., Agarwal A. SARS-CoV-2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services. Andrology. 2021;9(1):10-18. doi: 10.1111/andr.12809.
  15. Eisenberg M.L. Coronavirus disease 2019 and men’s reproductive health. Fertil Steril. 2020;113(6):1154. doi: 10.1016/j.fertnstert.2020.04.039.
  16. Salonia A., Corona G., Giwercman A., Maggi M., Minhas S., Nappi R.E., Sofikitis N., Vignozzi L. SARS-CoV-2, testosterone and frailty in males (PROTEGGIMI): A multidimensional research project. Andrology. 2020. Doi.org/10.1111/andr.12811.
  17. Papadopoulos V., Li L., Samplaski M. Why does Covid-19 kill more elderly men than women? Is there a role for testosterone? Andrology. 2020; 9(1):65-72.
  18. Gheblawi M., Wang K., Viveiros A., et al. Angiotensin converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system. Circ Res. 2020; 126(10):1456-1474.
  19. Kohn F.M., Miska W., Schill W.B. Release of angiotensin-converting enzyme (ACE) from human spermatozoa during capacitation and acrosome reaction. J Androl. 1995;16(3):259-265.
  20. Douglas G.C., O’Bryan M.K., Hedger M.P. et al. The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology. 2004;145(10):4703-4711.
  21. Wang Z., Xu X. scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells. 2020;9:4.
  22. Ziegler C.G.K., et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020. doi: 10.1016/j.cell.2020.04.035.
  23. Letko M., Marzi A., Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol. 2020;5(4):562-569.
  24. Perry M.J., Arrington S., Neumann L.M., Carrell D., Mores C.N. It is currently unknown whether SARS-CoV-2 is viable in semen or whether Covid-19 damages spermatozoa. Andrology. 2021 ;9(1):30-32. doi: 10.1111/andr.12831.
  25. Dutta S., Sengupta P. SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology. Reprod Sci. 2021;1:23-26. doi: 10.1007/s43032-020-00261-z
  26. White A. Men and Covid-19: the aftermath. Postgrad Med. 2020;supl4:18- 27. doi: 10.1080/00325481.2020.1823760
  27. Betron M., Gottert A., Pulerwitz J., Shattuck D., Stevanovic-Fenn N. Men and COVID-19: Adding a gender lens. Glob Public Health. 2020;15(7):1090- 1092. doi: 10.1080/17441692.2020.1769702.
  28. Simoni M, Hofmann MC. The Covid-19 pandemics: Shall we expect andrological consequences? A call for contributions to ANDROLOGY. Andrology. 2020;8(3):528-529. Doi.org/10.1111/andr.12804.
  29. Hallak J., Teixeira T.A., Bernardes F.S., Carneiro F., Duarte S.A.S., Pariz J.R., Esteves S.C., Kallas E., Saldiva P.H.N. SARS-CoV-2 and its relationship with the genitourinary tract: Implications for male reproductive health in the context of Covid-19 pandemic. Andrology. 2021;9(1):73-79. doi: 10.1111/andr.12896.
  30. Olaniyan O.T., Dare A., Okotie G.E.,Adetunji C.O., IbitoyeB.O.,Bamidele O.J., Eweoya O.O. Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility. J Basic Clin Physiol Pharmacol 2020;31(6). doi: 10.1515/jbcpp-2020-0156.
  31. Paoli D., Pallotti F., Turriziani O., Mazzuti L., Antonelli G., Lenzi A., Lombardo F. SARS-CoV-2 presence in seminal fluid: Myth or reality, Andrology. 2020;9(1):23-26. doi: 10.1111/andr.12825.
  32. Pascolo L., Zito G., Zupin L., Luppi S., Giolo E., MartinelliM., De Rocco D., Crovella S., Ricci G. Renin Angiotensin System, Covid-19 and Male Fertility: Any Risk for Conceiving? Microorganisms. 2020;8(10):1492. doi: 10.3390/microorganisms8101492.
  33. Song C., Wang Y., Li W, et al. Absence of 2019 novel coronavirus in semen and testes of Covid-19 patients. Biol Reprod. 2020;103(1):4-6.
  34. Zhang S., Wang X., Zhang H. et al. The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city. Reprod Toxicol. 2020;96:90-94.
  35. Hallak J., Teixeira T.A., Bernardes F.S., Carneiro F., Duarte S.A.S., Pariz J.R., Esteves S.C., Kallas E., Saldiva P.H.N. SARS-CoV-2 and its relationship with the genitourinary tract: Implications for male reproductive health in the context of COVID-19 pandemic Andrology. 2021;9(1):73-79. doi: 10.1111/andr.12896.
  36. Даренская М.А., Колесникова Л.И., Колесников С.И. Covid-19: окислительный стресс и актуальность антиоксидантной терапии. Вестник Российской академии медицинских наук. 2020 ;75 (4): 318- 325. doi: 10.15690/vramn1360
  37. Delgado-Roche L., Mesta F. Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection Archives of Medical Research. 2020;51(5):384-387. Doi.org/10.1016/j. arcmed.2020.04.019
  38. Laforge M., Elbim C., Frere C. et al. Tissue damage from neutrophil-induced oxidative stress in COVID-19. Nat Rev Immunol. 2020;20:515-516. Doi. org/10.1038/s41577-020-0407-1
  39. Cecchini R., Cecchini A.L., SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression, Medical Hypotheses. 2020;143:110102. Doi.org/10.1016/j.mehy.2020.110102.
  40. Polonikov A. Endogenous glutathione deficiency as the most likely cause of serious manifestations and death of patients with COVID-19. ACS Infect Dis. 2020;6(7):1558-1562.

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