Molecular genetic predictors of the development of urolithiasis


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Abstract

Urolithiasis is one of the most urgent problems of clinical urology. Currently, there is no consensus on the causes of stone formation, as well as the role of various factors in the development of urolithiasis, however, increasingly, according to various studies, the leading role is given to genetic causes. The article presents a modern review of data on genetic polymorphisms associated with ICD: rs1801197 and rs6776158 of the CASR gene; TaqI of the VDR gene; rs1801197 of the CALCR gene, rs3752472, rs650439, rs2853744 of the Klotho gene.

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About the authors

D. N Khotko

FGAOU VO Saratov State Medical University named after V. I. Razumovsky, Ministry of Health of Russia

Email: dnksar@list.ru
Candidate of Medical Sciences, Head of the urological department of University Hospital №1 n.a. S.R. Mirotvortsev

N. V Polukonova

FGAOU VO Saratov State Medical University named after V. I. Razumovsky, Ministry of Health of Russia

Email: polukonovanv@yandex.ru
Doctor of Biological Sciences, professor of the Department of general biology, pharmacognosy and botany, Head of the laboratory of cell technologies of the Center for experimental oncology

A. I Khotko

FGAOU VO Saratov State Medical University named after V. I. Razumovsky, Ministry of Health of Russia

Email: pivovarova-nastya@ya.ru
Candidate of Medical Sciences, Assistant of the Department of Urology

N. A Navolokin

FGAOU VO Saratov State Medical University named after V. I. Razumovsky, Ministry of Health of Russia

Email: nik-navolokin@yandex.ru
Candidate ofMedical Sciences, Associate Professor, Department of Pathological Anatomy, Head of the Experimental department of the Center for experimental oncology

A. I Tarasenko

FGAOU VO I.M. Sechenov First Moscow State Medical University (Sechenov University) Ministry of Health of Russia

Email: tar-art@yandex.ru
Candidate of Medical Sciences, Deputy Director for Innovative Development Director of the Institute of Urology and Reproductive Health

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