Biomarkers of prostate cancer and potential for using ace produced in prostate gland for diagnosis of prostate cancer and benign prostatic hyperplasia


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Abstract

Prostate cancer (PCa) is the 4th most commonly diagnosed cancer in the male population and incidence of different stages is increasing every year. The efficiency of PCa treatment is strongly dependent on the its stage. Prostate Specific Antigen (PSA) is the most widely used and universal biomarker of PCa worldwide. Considering its limited predictive value, particularly in patients older than 50 with PSA level ranging from 4.5 to 10 ng/ml, there is a need to introduce new serum biomarkers of PCa. Current data on different PCa biomarkers are reviewed in the article as well as a role of angiotensin-converting enzyme (ACE) as a novel PCa biomarker.

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About the authors

A. A Kamalov

Moscow State University; Medical Scientific and Educational Center of Lomonosov Moscow State University; GBUZ “City Clinical Hospital №31”

Email: armais.kamalov@rambler.ru
academician of the RAS, MD, professor, Chief of the Medical Scientific and Educational Center

L. M Samokhodskaya

Moscow State University; Medical Scientific and Educational Center of Lomonosov Moscow State University

Email: SLM@fbm.msu.ru
doctor-biochemist, Ph.D., associate professor, Head of the Department of Laboratory Diagnostics

V. K Karpov

Moscow State University; Medical Scientific and Educational Center of Lomonosov Moscow State University; GBUZ “City Clinical Hospital №31”

Email: vk_karpov@mail.ru
Ph.D., associate professor at the Department of Urology and Andrology of Faculty of Fundamental Medicine

D. A Okhobotov

Moscow State University; Medical Scientific and Educational Center of Lomonosov Moscow State University; GBUZ “City Clinical Hospital №31”

Email: 14072003m@gmail.com
urologist

V. N Mamedov

Moscow State University; Medical Scientific and Educational Center of Lomonosov Moscow State University; GBUZ “City Clinical Hospital №31”

Email: mvadim_91@yahoo.com
Ph.D. student, Department of Urology and Andrology of Department of Urology and Andrology, Faculty of Fundamental Medicine

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