Current opportunities for symptomatic treatment of dysuria


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Dysuria is the one of the most common conditions in urology. Although dysuria is not an independent disease, it accompanies a wide range of urological diseases of both infectious and non-infectious origin. Dysuria is traditionally understood as a feeling of discomfort, a burning sensation, or a sensation of pain during urination. Despite a significant reduction in the quality of life of this category of patients, pathogenetic treatment of the underlying cause is often performed in routine clinical practice, while the dysuria itself can remain without proper attention. The current possibilities of symptomatic relief of dysuria are reviewed in this article.

Full Text

Restricted Access

About the authors

A. Z Vinarov

FGAOU VO of I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)

Email: avinarov@mail.ru
MD, professor, Institute of Urology and Male Reproductive Health named

L. G Spivak

FGAOU VO of I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)

Email: leonid.spivak@gmail.com
Associate professor, Institute of Urology and Male Reproductive Health named

References

  1. Gerber G.S., Brendler C.B. Evaluation of the urologic patient: history, physical examination, and urinalysis. In: Wein A.J., et al.; eds. Campbell-Walsh Urology. 10th ed. Philadelphia, Pa.: Elsevier Saunders 2012: 75-76.
  2. Bremnor J.D., Sadovsky R. Evaluation of dysuria in adults. Am Fam Physician 2002;65(8):1589-1596.
  3. Hanno P., Nordling J., Fall M. Bladder pain syndrome. Med Clin North Am 2011;95(1):55-73.
  4. Richardson D.A. Dysuria and urinary tract infections. Obstet Gynecol Clin North Am 1990;17:881-888.
  5. Sommer P., Nielsen K.K., Bauer T, et al. Voiding patterns in men evaluated by a questionnaire survey. Br J Urol 1990;65:155-160.
  6. Wyndaele J.J., De Wachter S. The sensory bladder (1): an update on the different sensations described in the lower urinary tract and the physiological mechanisms behind them. Neurourol Urodyn 2008;27(4):274-278.
  7. Kulkarni S.K. Antispasmodics - A new perspective. JAMA India 2001;4(8):119-121.
  8. Roxburgh C., Cook J., Dublin N. Anticholinergic drugs versus other medications for overactive bladder syndrome in adults. Cochrane Database Syst Rev 2007;(3):CD003190.
  9. Chapple C.R., Khullar V., Gabriel Z., Muston D., Bitoun C.E., Weinstein D. The Effects of Antimuscarinic Treatments in Overactive Bladder: An Update of a Systematic Review and Meta-Analysis. Eur Urol 2008; 54(3): 543-562.
  10. Sri Sivalingam, Manoj Monga. Management of Ureteral Stent Discomfort in Contemporary Urology Practice. Urology Practice 1 (2014), 141-145.
  11. Deliveliotis C., Chrisofos M., Gougousis E. et al. Is there a role for alpha1-blockers in treating double-J stent-related symptoms? Urology. 2006;67:35.
  12. Beddingfield R., Pedro R.N., Hinck B. et al. Alfuzosin to relieve ureteral stent discomfort: a prospective, randomized, placebo controlled study. J Urol 2009; 181: 170.
  13. Dellis A.E., Keeley F.X. Jr, Manolas V. et al. Role of a-blockers in the treatment of stent-related symptoms: a prospective randomized control study. Urology 2014; 83: 56.
  14. Nakada S.Y., Jerde T.J., Bjorling D.E. et al. Selective cyclooxygenase-2 inhibitors reduce ureteral contraction in vitro: a better alternative for renal colic? J Urol 2000; 163: 607.
  15. Kyungtae Ko, Won Ki Lee, Cheol Young Oh et al. Is A Combination of Antibiotics and Non-Steroidal Anti-Inflammatory Drugs More Beneficial Than Antibiotic Monotherapy For The Treatment of Female Acute Uncomplicated Cystitis? A Randomized Controlled Pilot Study. Female Urology 2018; 15(06):365-369.
  16. Gagyor I., Bleidorn J., Kochen M.M., Schmiemann G., Wegscheider K., Hummers-Pradier E. Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial. BMJ. 2015;23;351:h6544.
  17. Kulchavenya E. Acute uncomplicated cystitis: is antibiotic unavoidable? Ther Adv Urol 2018;10(9):257-262.
  18. Lars Bjerrum, Morten Lindbxk. Which treatment strategy for women with symptoms of urinary tract infection? BMJ 2015; 351:h6888. Published online 2015 Dec 29.
  19. Yan H., Wang Y., Sun R., Cui Y. The Efficacy of Antimuscarinics Alone or in Combination with Alpha-Blockers for the Treatment of Ureteral Stent-Related Symptoms: A Systematic Review and Meta-Analysis. Urol Int 2017;99(1):6-13.
  20. Gupta O.P., Aggarwal K.K. Role of Phenazopyridine in Urinary Tract Infections. Indian Journal of Clinical Practice 2012; 22(9):437-441.
  21. Kinnman E., Nygards E.B., Hansson P. Peripheral alpha-adrenoreceptors are involved in the development of capsaicin induced ongoing and stimulus evoked pain in humans. Pain 1997;69:79-85.
  22. Ye Z.Q., Lan R.Z., Yang W.M. et al. Tamsulosin treatment of chronic non-bacterial prostatitis. J. Int. Med. Res. 2008; 36(2):244-252.
  23. Lamb A.D., Vowler S.L., Johnston R., Dunn N., Wiseman O.J. Metaanalysis showing the beneficial effect of alpha-blockers on ureteric stent discomfort. BJU Int. 2011;108(11):1894-1902.
  24. Yakoubi R., Lemdani M., Monga M., Villers A., Koenig P. Is there a role for alpha-blockers in ureteral stent related symptoms? A systematic review and meta-analysis. J Urol. 2011;186(3):928-934.
  25. Kwon J.K., Cho K.S., Oh C.K., Kang D.H., Lee H, Ham W.S., Choi Y.D., Lee J.Y. The beneficial effect of alpha-blockers for ureteral stent-related discomfort: systematic review and network meta-analysis for alfuzosin versus tamsulosin versus placebo. BMC Urol. 2015;24:15-55.
  26. Vassilis Pergialiotis, Pantelis Arnos, Michael N Mavros, Eleni Pitsouni, Stavros Athanasiou, Matthew E Falagas. Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? Expert Rev. Anti Infect. Ther 2012; 10(8), 875-879.
  27. Jenkins G.L., Hartung W. The Chemistry of Organic Medicinal Products. Uchebnoe posobie. M.: Gosudarstvennoe izdatel’stvo inostrannoi literatury; 1949. Russian (Дженкинс Г.Н, Хартунг У. Химия органических лекарственных препаратов. Учебное пособие. М.: Государственное издательство иностранной литературы; 1949).
  28. Ramesh Hotchandani, Aggarwal K.K. Urinary Tract Infections in Women. Indian Journal of Clinical Practice 2012; 23(4):187-192.
  29. https://clincalc.com/drugstats/drugs/phenazopyridine. Доступ от 13.12.2018
  30. Thomas B.H., Whitehouse L.W., Solomonraj G., Paul C.J. Metabolism and disposition of phenazopyridine in rat. Xenobiotica 1993;23(2):99-105.
  31. Naoki Aizawa, Jean-Jacques Wyndaele. Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen. Neurourol. Urodynam 2010;29: 1445-1450.
  32. Kirwin T.J., Lowsley A.S., Menning J. The effects of Pyridium in certain urogenital infections. Am J Surg 1943;62:330-335.
  33. Zelenitsky S.A., Zhanel G.G. Phenazopyridine in urinary tract infections, Ann Pharmacother. 1996;30(7-8):866-888.
  34. Trickett P.C. Ancillary use of phenazopyridine (Pyridium) in urinary tract infections. CUIT Ther Res 1970;12:441-445.
  35. Gould S. Clinical comparison of flavoxate and phenazopyridine. Urology 1975;5:612-615.
  36. Gilderman L., Hendry D., Patrick K. Evaluation of the efficacy of phenazopyridine Hydrochloride (Formula PD-F-0016) as a urinary analgesic in women with urinary tract infections. FDA’s Dockets Management. Protocol Number: 99-001-P (2001). www.fda.gov
  37. Deepalatha C., Deshpande N. A comparative study of phenazopyridine (pyridium) and cystone as short-term analgesic in uncomplicated urinary tract infection. Int J Pharm Pharm Sci 2011;3(Suppl 2):224-226.
  38. Marceli'n-Jimenez G., Angeles A.P., Martinez-Rossier L. et al. Ciprofloxacin Bioavailability is Enhanced by Oral Co-Administration with Phenazopyridine Clin. Drug Investig. 2006; 26:323
  39. Kasymov A.A. Use of Uropirin for treatment ofpatients with inflammatory diseases of lower urinary tract. Medicina 2012;5:3. Russian (Касымов А.А. Применение препарата Уропирин в лечении больных с воспалительными заболеваниями нижних мочевых путей. Медицина 2012;5:39).
  40. Fischer K.M., Louie M. Ureteral Stent Discomfort and Its Management. P. Curr Urol Rep, 2018; 19: 64.
  41. Norris R.D., Sur R.L., Springhart W.P., Marguet C.G., Mathias B.J., Pietrow P.K., Albala D.M., Preminger G.M. A prospective, randomized, double-blinded placebo-controlled comparison of extended release oxybutynin versus phenazopyridine for the management of postoperative ureteral stent discomfort. Urology 2008;71(5):792-795.
  42. Nazarko L. Bladder pain from indwelling urinary catheterization: case study. Br J Nurs 2007;16(9):511-2,514.
  43. Yu C.H., Wang C.H., Chang C.C. Chocolate colored blood with normal artery oxygen: methemoglobinemia related to phenazopyridine. Am. J. Med. Sci 2011; 341(4): 337.
  44. Haigh C., Dewar J.C. Multiple adverse effects of pyridium: a case report. South. Med. J 2006; 99(1): 90-92.
  45. Vega J. Acute renal failure caused by phenazopyridine. Rev. Med. Chil 2003;131(5):541-544.
  46. Rivas R., Martinez Torres A., Bohorques R., Martinez Albelo I. Acute kidney failure caused by phenazopyridine overdose. Nefrologia 2001; 21(1):97-98.
  47. Siddiqui M.A. Chronic severe hemolytic anemia from phenazopyridine. Ann. Intern. Med 1995; 122(2): 156-157.
  48. Thomas R.J., Doddabele S., Karnad A.B. Chronic severe hemolytic anemia related to surreptitious phenazopyridine abuse. Ann. Intern. Med 1994;121(4):308.
  49. Shahani L., Sattovia S. Acquired methaemoglobinaemia related to phenazopyridine ingestion. BMJ Case Reports. 2012;2012.
  50. Shatila W., Clark A. Unexplained hypoxia in a woman presenting with acute on chronic abdominal pain. Am J Med. 2013; 126:e1-2.
  51. Daly J.S., Hultquist D.E., Rucknagel D.L. Phenazopyridine induced methaemoglobinaemia associated with decreased activity of erythrocyte cytochrome b5 reductase. J Med Genet 1983;20:307-309.
  52. Banimahd F., Loo, T., Amin M., Ahadiat O. R., Chakravarthy B., Lotfipour S. A Rare but Important Clinical Presentation of Induced Methemoglobinemia. The western journal of emergency medicine 2016; 17(5): 627-629.
  53. Holmes I., Berman N., Domingues V. Acute Renal Failure and Jaundice without methemoglobinemia in a Patient with Phenazopyridine Overdose: Case Report and Review of the Literature. Case Rep Nephrol. 2014;2014:845372.
  54. Nathan D.M., Siegel A.J., Bunn H.F. Acute methemoglobinemia and hemolytic anemia with phenazopyridine: possible relation to acute renal failure. Arch Intern Med 1977;137(11):1636-1638.
  55. Christensen C.M., Farrar H.C., Kearns G.L. Protracted methemoglobinemia after phenazopyridine overdose in an infant. J Clin Pharmacol 1996;36(2):112-116.
  56. Gold N.A., Bithoney W.G. Methemoglobinemia due to ingestion of at most three pills of pyridium in a 2-year-old: case report and review. J Emerg Med 2003;25(2):143-148.
  57. Jeffery W.H., Zelicoff A.P., Hardy W.R. Acquired methemoglobinemia and hemolytic anemia after usual doses of phenazopyridine. Drug Intell Clin Pharm 1982;16(2):157-159.
  58. Gavish D., Knobler H., Gottehrer.N, Israeli A., Kleinman Y. Methemoglobinemia, muscle damage and renal failure complicating phenazopyridine overdose. Isr J Med Sci 1986;22(1):45-47.
  59. Sand R.E., Edelmann C.M. Jr. Pyridium-induced methemoglobinemia. Report of a case. J Pediatr 1961;58:845-48.
  60. Truman T.L., Dallessio J.J., Weibley R.E. Life-threatening Pyridium Plus intoxication: a case report. Pediatr Emerg Care 1995;11(2):103-16.
  61. Zimmerman R.C., Green E.D., Ghurabi W.H., Colohan D.P. Methemoglobinemia from overdose of phenazopyridine hydrochloride. Ann Emerg Med 1980;9(3):147-149.
  62. Landman J., Kavaler E., Waterhouse R.L. Jr. Acquired methemoglobinemia possibly related to phenazopyridine in a woman with normal renal function. J Urol 1997;158(4):1520-1521.
  63. Conroy J.M., Baker J.D. 3rd, Martin W.J., Bailey M.K., Dorman B.H. Acquired methemoglobinemia from multiple oxidants. South Med J 1993;86(10):1156-1159.
  64. Randazzo G.P., Ford E.A., Glauser F.L. Methemoglobinemia caused by acute overdosage of phenazopyridine. West J Med 1975; 122(5) 427-429.
  65. Crawford S.E., Moon A.E. Jr, Panos T.C., Hooks C.A. Methemoglobinemia associated with pyridium administration; report of a case. J Am Med Assoc 1951 5;146(1):24-25.
  66. Lee M., Bozzo P., Einarson A., Koren G. Urinary tract infections in pregnancy. Can Fam Physician 2008;54(6):853-854.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2019 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies