AFALAZA IN THE MANAGEMENT OF PATIENTS WITH CHRONIC PELVIC PAIN SYNDROME


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Abstract

Introduction. Currently, chronic pelvic pain syndrome (CPPS) is one of the most prevalent urological diseases, but due to the multifactorial nature of the disease and the lack of consensus on its pathogenesis, the issue of adequate therapy remains open. Since the vascular factor plays the major role in the pathogenesis of CPPS, we hypothesized that this category of patients has microcirculatory disturbances of the prostate. Aim. Detection of microcirculatory disturbances of the prostate, their correction, and evaluation of the effect on the course of CPPS. Materials and methods. The study comprised 60 healthy, sexually active men with clinical manifestations of CPPS lasting from 6 months to 5 years. After a comprehensive examination, all patients received Afalaza 2 tablets twice daily for 16 weeks. At the end of week 16, patients were re-examined. Results. In patients with CPPS, therapy with Afalaza resulted in a significant improvement in microcirculation in the prostate thus leading to the reduction of the severity of disease manifestations.

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About the authors

A. I Neimark

Altai State Medical University of Minzdrav of Russia

Email: urologagmu@mail.ru
Dr.Med.Sci., Prof., Head of the Department of Specialized Surgery in Urology, Traumatology and Ophthalmology Barnaul, Russia

B. A Neimark

Altai State Medical University of Minzdrav of Russia

Email: urologagmu@mail.ru
Dr.Med.Sci., Prof. at the Department of Specialized Surgery in Urology, Traumatology and Ophthalmology Barnaul, Russia

N. A Nozdrachev

Altai State Medical University of Minzdrav of Russia

Email: nozdrachevuro@mail.ru
Ph.D., Associate Professor at the Department of Specialized Surgery in Urology, Traumatology and Ophthalmology Barnaul, Russia

Yu. S Kondrat’eva

Altai State Medical University of Minzdrav of Russia

Email: Julia jsk@mail.ru
Dr.Med.Sci., Prof., Head of the Department of Dermatovenereology, Cosmetology and Immunology Barnaul, Russia

D. V Borisenko

Altai State Medical University of Minzdrav of Russia

Email: urologagmu@mail.ru
Clinical resident at the Department of Specialized Surgery in Urology, Traumatology and Ophthalmology Barnaul, Russia

D. O Arkhipov

Altai State Medical University of Minzdrav of Russia

Email: urologagmu@mail.ru
6th year student, Head of SSS in Urology Barnaul, Russia

A. A Makarova

Altai State Medical University of Minzdrav of Russia

Email: urologagmu@mail.ru
6th year student, Head of SSS in Urology Barnaul, Russia

P. A Oberemok

Altai State Medical University of Minzdrav of Russia

Email: urologagmu@mail.ru
6th year student, Head of SSS in Urology Barnaul, Russia

References

  1. Davidov M.I. Etiology of chronic prostatitis. Plenum PravIeniya ROU: materialy. Saratov. 2004;333-334 p.
  2. Loran O.B., Pushkar’ D.Yu., Segal A.S., Yudovskii S.O. Our understanding of the problem of chronic prostatitis. Farmateka. 2002;10:69-75.
  3. Sivkov A.V., Romikh V.V., Zakharchenko A.V. IIIB Chronic prostatitis/chronic pelvic pain syndrome and sexual dysfunction. Andrologiya i genital’naya khirurgiya. 2015;4:18-26.
  4. Keltikangas-Järvinen L. Role of psychological factors in somatic diseases: a challenge for current behavioral medicine. Ann Med. 1989;21(4):255-256.
  5. de la Rosette J.J., Ruijgrok M.C., Jeuken J.M., Karthaus H.F., Debruyne F.M. Personality variables involved in chronic prostatitis. UroIogy. 1993;42(6):654-662.
  6. Mehik A., Hellström P., Sarpola A., Lukkarinen O., Järvelin M.R. Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int. 2001;88(1):35-38.
  7. Berghuis J.P., Heiman J.R., Rothman I., Berger R.E. Psychological and physical factors involved in chronic idiopathic prostatitis. J Psychosom Res. 1996;41(4):313-325.
  8. Krieger J.N., Nyherg L. Jr., Nickel J.S. NIH consensus definition and classification of prostatitis. JAMA 1999;282(3):236-237.
  9. Loran O.B., Segal A.S. Chronic prostatitis. Materials X Russian Congress of urology. M., 2002. Р. 209-222.
  10. McNaughton Collins M., MacDonald R., Wilt T.J. Diagnosis and treatment of chronic abacterial prostatitis: a systematic review. Ann Intern Med. 2000;133(5):367-381.
  11. Mazo E.B., Koryakin M.B., Akopyan A.S. Hemodynamic prerequisites for the development of prostatitis in left-sided varicocele. Urologiya i nefrologiya. 1993;4:5-8.
  12. Neimark A.I., Lomshakov A.A. Dopplerography in the diagnosis of chronicprostatitis.UroIogiia.2000;6:21-23
  13. Borovskaya T.G., Fomina T.I., Loskutova O.P., Baranova O.V., Sergeeva S.A., Martyushev A.V., Epshtein O.I. Antibodies to prostate-specific antigen in uItra-Iow doses: the effect on the morphological and functional state of the prostate of rats. ByulIeten’ eksperimental’noi i biologicheskoi meditsiny. 2002
  14. Dorofeev S.D., Kudryavtsev Yu.V., Kudryavtseva L.V. ImmunohistochemicaI aspects of chronic prostatitis. Effektivnaya farmakoterapiya. 2014;2:26-38.
  15. Neimark A.I., Isaenko V.I., Yakovets Ya.V., Simashkevich A.V., Aliev R.T. Use of Afala in urology practice. Urologiia. 2009;3:67-70.
  16. Neimark A.I., Aliev R.T., Muzalevskaya N.I., Krainichenko S.V., Vorob’eva E.N., Tarasova T.S. Use of Impaza in the management of erectiIe dysfunction in patients with essentiaI hypertension and ischemic heart disease. ByulIeten’ eksperimental’noi biologii i meditsiny. 2009;8:76-79.

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