USING OF CELL BIOCOMPOSITE MATERIAL IN TISSUE ENGINEERING OF THE URINARY BLADDER


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Abstract

In a systematic review, to present an overview of the current situation in the field of tissue engineering of urinary bladder related to the use of cell lines pre-cultured on matrices. The selection of eligible publications was conducted according to the method described in the article Glybochko P.V. et al. "Tissue engineering of urinary bladder using acellular matrix." At the final stage, studies investigating the application of matrices with human and animal cell lines were analyzed. Contemporary approaches to using cell-based tissue engineering of the bladder were analyzed, including the formation of 3D structures from several types of cells, cell layers and genetic modification of injected cells. The most commonly used cell lines are urothelial cells, mesenchymal stem cells and fibroblasts. The safety and efficacy of any types of composite cell structures used in the cell-based bladder tissue engineering has not been proven sufficiently to warrant clinical studies of their usefulness. The results of cystoplasty of rat bladder are almost impossible to extrapolate to humans; besides, it is difficult to predict possible side effects. For the transition to clinical trials, additional studies on relevant animal models are needed.

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About the authors

P. V Glybochko

I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia

Email: rectorat@mma.ru
Academician of the RAS, Dr.Med.Sci., Prof., Rector

Yu. V Olefir

Scientific Center on Expertise of Medical Application Products of Minzdrav of Russia

Email: olefir@expmed.ru
Dr.Med.Sci., Director General of Scientific Center on Expertise

Yu. G Alyaev

I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia

Email: ugalyaev@mail.ru
Corr.-Member of the RAS, Dr.Med.Sci., Professor, Head of Department of Urology

D. V Butnaru

I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia

Email: butnaru_dv@mail.ru
PhD, Director of the Institute of Regenerative Medicine

E. A Bezrukov

I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia

Email: cabezrukov@rambler.ru
Dr.Med.Sci., Prof. at the Department of Urology

A. A Chaplenko

Scientific Center on Expertise of Medical Application Products of Minzdrav of Russia

Email: a.a.chaplenko@yandex.ru
Expert at the Laboratory of Biomedical Cell Products

T. M Zharikova

I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia

Email: tanyushaz@mail.ru
Researcher at the Research Institute for Uronephrology and Human Reproductive Health

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