NEW APPROACHES FOR RECOVERY OF ERECTILE FUNCTION IN PATIENTS AFTER RADICAL PROSTATECTOMY


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Prostate cancer (PCa) is one of the most common maligmancies and causes of death among men. Radical prostatectomy (RP) is optimal and recommended treatment modality for localized prostate cancer. More than half of all men undergoing surgery experience problems with erectile function and existing treatments do not provide a positive effect. Thus, there is a need for new approaches to the restoration of erectile function in patients after RP. One of these is the use of cell technologies, namely the stromal-vascular fraction and autologous platelet-rich plasma. This review examines the results of preclinical and clinical studies investigating the efficacy and safety of these treatment options in erectile dysfunction.

Full Text

Restricted Access

About the authors

M. V Epifanova

Research Institute for Uronephrology and Human Reproductive Health

Email: epifanova_maya@mail.ru
Ph.D., Leading Researcher at the Research Institute for Uronephrology and Human Reproductive Health

M. E Chalyi

I.M. Sechenov First MSMU (Sechenov University)

Email: chalyy@bk.ru
Dr.Med.Sci., Prof. at the Department of Urology, Medical Faculty

B. R Gvasaliya

The 3rd A.A. Vishnevsky Central Military Clinical Hospital of Ministry of Defense of Russia

Email: bgvasaha@gmail.com
Dr.Med.Sci., Prof. at the Department of Clinical Andrology, FPE

I. I Eremin

Institute of General Pathology and Pathophysiology

Email: cd105@mail.ru
Ph.D., Leading Researcher at the Laboratory of Cell Biology and Developmental Pathology

A. A Pulin

Institute of General Pathology and Pathophysiology

Email: andreypulin@gmail.com
Ph.D., Leading Researcher at the Laboratory of Cell Biology and Developmental Pathology

I. I Nadelyaeva

Central State Medical Academy

Email: nadirina@mail.ru
Teaching Assistant at the Department of Health Care Management and Public Health, Rehabilitation Medicine and Medical Rehabilitation with Courses of Obstetrics and Gynecology, Ophthalmology, Pediatrics, Nursing, Clinical Psychology And Pedagogy

S. A Artemenko

I.M. Sechenov First MSMU (Sechenov University)

Email: sergey.artemenko.94@mail.ru
Fifth Year Student, Directorate of Educational Programs

D. A Galitskaya

I.M. Sechenov First MSMU (Sechenov University)

Email: dgalitsk@gmail.com
Fifth Year Student, Directorate of Educational Programs

A. M Repin

I.M. Sechenov First MSMU (Sechenov University)

Email: andrei54@list.ru
Fifth Year Student, Directorate of Educational Programs

References

  1. Chung E., Gillman M. Prostate cancer survivorship: A review of erectile dysfunction and penile rehabilitation after prostate cancer therapy. Med. J. Aust. 2014;200(10):582-585.
  2. Ferlay J., Steliarova-Foucher E., Lortet-Tieulent J., Rosso S., Coebergh J.W., Comber H., Forman D., Bray F. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer. 2013;49:1374-1403.
  3. Kaprin A.D., Starinskii V.V., Petrova G.V. Malignant neoplasms in Russia in 2013. M. 2015;9-15. Кгыышфт (Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2013 году. М. 2015;9-15).
  4. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., Thun M.J. Cancer statistics, 2008. CA Cancer J Clin. 2008;58(2):71-96.
  5. European Association of Urology. Guidelines. 2016 edition.
  6. Schaeffer E.M., Carter H.B., Kettermann A., Loeb S., Ferrucci L., Landis P., Trock B.J., Metter E.J. Prostate specific antigen testing among the elderly - when to stop. J Urol. 2009;181(4):1606-1614.
  7. Goode R.R., Marshall S.J., Duff M., Chevli E., Chevli K.K. Use of PCA3 in detecting prostate cancer in initial and repeat prostate biopsy patients. Prostate. 2013;73(1):48-53.
  8. Lin D.W., Newcomb L.F., Brown E.C., Brooks J.D., Carroll P.R., Feng Z., Gleave M.E., Lance R.S., Sanda M.G., Thompson I.M., Wei J.T., Nelson P.S. Urinary TMPRSS2:ERG and PCA3 in an Active Surveillance Cohort: Results from a Baseline Analysis in the Canary Prostate Active Surveillance Study. Clin Cancer Res. 2013;19:2442-2450.
  9. Salonia A., Burnett A.L., Graefen M., Hatzimouratidis K., Montorsi F., Mulhall J.P., Stief C. Prevention and management of postprostatectomy sexual dysfunctions part 2: recovery and preservation of erectile function, sexual desire, and orgasmic function. Eur Urol. 2012;62: 273-286.
  10. Väänänen R.M., Lilja H., Kauko L., Helo P., Kekki H., Cronin A.M., Vickers A.J., Nurmi M., Alanen K., Bjartell A., Pettersson K. Cancer-associated changes in the expression of TMPRSS2-ERG, PCA3, and SPINK1 in histologically benign tissue from cancerous vs noncancerous prostatectomy specimens. Urology. 2014;83(2):511.
  11. Urology. Russian clinical guidelines. Ed. Yu.G. Alyaev, P.V. Glybochko, D.Yu. Pushkar. M.: GEOTAR- Media. 2016;496 p.
  12. Capogrosso P., Salonia A., Briganti A., Montorsi F. Postprostatectomy Erectile Dysfunction: A Review. World J Mens Health. 2016; 34(2):73-88.
  13. Meyer J.P., Gillat D.A., Lockyer R., MacDonagh R. The effect of erectile dysfunction on quality of life of men after radical prostatectomy. BJU Int. 2003;92:929-931.
  14. Kimberley Hoyland, MBBS, Nikhil Vasdev, ChM (Urol), FRCS (Urol), Ahmed Abrof, FRCS (Urol), and Gregory Boustead, FRCS (Urol). Post-Radical Prostatectomy Incontinence: Etiology and Prevention. Rev Urol. 2014;16(4):181-188.
  15. Crystal L. Park, PhD, Ianita Zlateva, MPH, and Thomas O. Blank, PhD. Self-identity After Cancer: «Survivor», «Victim», «Patient», and «Person with Cancer». J Gen Intern Med. 2009; 24(2):430-435.
  16. Penson D.F., McLerran D., Feng Z., Li L., Albertsen P.C., Gil- liland F.D., Hamilton A., Hoffman R.M., Stephenson R.A., Potosky A.L., Stanford J.L. 5-year urinary and sexual outcomes after radical prostatectomy: Results from the prostate cancer outcomes study. J Urol. 2005;173:1701-1705.
  17. Coleman M. Axon degeneration mechanisms: Commonality amid diversity. Nat Rev Neurosci. 2005;6:889-898.
  18. Wang L., Sanford M.T., Xin Z., Lin G., Lue T.F. Role of Schwann cells in the regeneration of penile and peripheral nerves. Asian Journal of Andrology. 2015;17:776-782.
  19. Lagoda G., Sezen S.F., Burnett A.L. FK506 and rapamycin neuroprotect erection and involve different immunophilins in a rat model of cavernous nerve injury. J Sex Med. 2009;6:1914-1923.
  20. Leungwattanakij S., Bivalacqua T.J., Usta M.F., Yang D.Y., Hyun J.S., Champion H.C., Abdel-Mageed A.B., Hellstrom W.J. Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum. J Androl. 2003;24:239-245.
  21. Gajbhiye S.V., Jadhav K.S., Marathe P.A., Pawar D.B. Animal models of erectile dysfunction. Indian J Urol. 2015;31:15-21.
  22. Canguven O., Burnett A. Cavernous nerve injury using rodent animal models. J Sex Med. 2008;5:1776-1785.
  23. Wu C.C., Wu Y.N., Ho H.O., Chen K.C., Sheu M.T. Chiang The neuroprotective effect of platelet-rich plasma on erectile function in bilateral cavernous nerve injury rat model J Sex Med. 2012; 9(11):2838-48.
  24. Ferguson J.E., Carson C.C. Phosphodiesterase type 5 inhibitors as a treatment for erectile dysfunction: Current information and new horizons. Arab Journal of Urology. 2013;11(3):222-229.
  25. Song W., Ko K.J., Shin S.J., Ryu D.S. Penile Abscess Secondary to Neglected Penile Fracture after Intracavernosal Vasoactive Drug Injection Worl J MensHealth. 2012;30(3):189-191.
  26. Raina R., Agarwal A., Ausmundson S., Lakin M., Nandipati K.C., Montague D.K., Mansour D., Zippe C.D. Early use ofvacuum constriction device following radical prostatectomy facilitates early sexual activity and potentially earlier return of erectile function. Int. J. Impot. Res. 2006;18:77-81.
  27. Kim J.H., Lee S.W. Current status of penile rehabilitation after radical prostatectomy. Korean J Urol. 2015;56(2):99-108.
  28. Chung E., Brock G. Sexual rehabilitation and cancer survivorship: a state of art review of current literature and management strategies in male sexual dysfunction among prostate cancer survivors. J Sex Med. 2013;10(1):102-111.
  29. Tamer Aboushwareb and Anthony Atala. Stem cells in urology. Nature clinical practice UROLOGY. 2008;5(11):621-631.
  30. Kim J.H., Song Y.S. Current status of stem cell therapy in urology. Korean J Urol. 2015;56(6):409-411.
  31. Johal K.S., Lees V.C., Reid A.J. Adipose-derived stem cells: selecting for translational success. Regen. Med. 2015;10(1):79-96.
  32. Lin C.S., Xin Z.C., Wang Z., Deng C., Huang Y.C., Lin G., Lue T.F. Stem Cell Therapy for Erectile Dysfunction: A Critical Review. Stem Cells Dev. 2012;21(3):343-351.
  33. Huang S.J., Fu R.H., Shyu W.C., Liu S.P., Jong G.P., Chiu Y.W., Wu H.S., Tsou Y.A., Cheng C.W., Lin S.Z. Adipose-derived stem cells: isolation, characterization, and differentiation potential. Cell Transplant. 2013;22(4):701-709.
  34. Gentile P., Orlandi A., Scioli M.G., Di Pasquali C., Bocchini I., Cervelli V. Concise review: adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical implications for tissue engineering therapies in regenerative surgery. Stem Cells Transl. Med. 2012;1(3):230-236.
  35. Kapur S.K., Katz A.J. Review of the adipose derived stem cell secretome. Biochimie. 2013;95(12):2222-22228.
  36. Dai R., Wang Z., Samanipour R., Koo K.I., Kim K. Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications. Stem Cells International. 2016;19 pages.
  37. You D., Jang M.J., Kim B.H., Song G., Lee C., Suh N., Jeong I.G., Ahn T.Y., Kim C.S. Comparative Study of Autologous Stromal Vascular Fraction and Adipose-Derived Stem Cells for Erectile Function Recovery in a Rat Model of Cavernous Nerve Injury. Stem Cells Transl Med. 2015;4(4):351-358.
  38. Haahr M.K., Jensen C.H., Toyserkani N.M., Andersen D.C., Damkier P., Sоrensen J.A., Lund L., Sheikh S.P. Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. EBioMedicine. 2016;5:204-210.
  39. Glybochko P.V., Chalyi M.E., Epifanova M.V., Eremin I.I., Pulin A.A. The method of treatment of erectile dysfunction. Patent na izobretenie RF № 2622757. Moskva. 19 June 2017. Byulleten’ № 17 ot 19.06.2017.
  40. Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Erectile Dysfunction. Identifier: NCT02472431.
  41. Nurden A.T., Nurden P., Sanchez M., Andia I., Anitua E. Platelets and wound healing. Frontiers in bioscience: a journal and virtual library. Front Biosci. 2008;13:3532-3548.
  42. Pavlovic V., Ciric M., Jovanovic V., Stojanovic, P. Platelet Rich Plasma: a short overview of certain bioactive components. Open Medicine. 2016;11(1):242-247.
  43. Sclafani A.P. Applications of platelet-rich fibrin matrix in facial plastic surgery. Facial Plastic Surgery. 2009;25(04):270-276.
  44. Middleton K.K., Barro V., Muller B., Terada S., Fu F.H. Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue injuries. The Iowa orthopaedic journal. 2012;32:150.
  45. Kececi Y., Ozsu S., Bilgir O. A cost-effective method for obtaining standard platelet-rich plasma. Wounds. 2014;26(8):232-238.
  46. Patel A.N., Selzman C.H., Kumpati G.S., McKellar S.H., Bull D.A. Evaluation of autologous platelet rich plasma for cardiac surgery: outcome analysis of 2000 patients. Journal of cardiothoracic surgery. 2016;11(1):62.
  47. Taschieri S., Lolato A., Ofer M., Testori T., Francetti L., Del Fabbro M. Immediate post-extraction implants with or without pure platelet-rich plasma: a 5-year follow-up study. Oral and Maxillofacial Surgery. 2017;21(2):147-157.
  48. Smith P.A. Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis An FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial. Am J Sports Med. 2016;44(4):884-891.
  49. Filardo G., Kon E., Buda R., Timoncini A., Di Martino A., Cenacchi A., Fornasari P.M., Giannini S., Marcacci M. Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2011;19(4):528-535.
  50. San Sebastian K.M., Lobato I., Hernandez I., Burgos-Alonso N., Gomez-Fernandez M.C., Lopez J.L., Rodriguez B., March A.G., Grandes G., Andia I. Efficacy and safety of autologous platelet rich plasma for the treatment of vascular ulcers in primary care: Phase III study. BMC Fam Pract. 2014;15:211.
  51. Kaya F., Kismet K., Ozer H., Soylu V.G., Duymus M.E., Akgun Y.A., Demir A., Celepli P., Guclu T., Bolat S., Ertas E. Can platelet-rich plasma be used safely in intra-abdominal operations? Bratisl Lek Listy. 2016;117(9):525-529.
  52. Wu Y.N., Wu C.C., Sheu M.T., Chen K.C., Ho H.O., Chiang H.S. Optimization of plateletrich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model. Journal of tissue engineering and regenerative medicine. J Tissue Eng Regen Med. 2016;10(10):294-304. doi: 10.1002/term.1806. Epub 2013 Aug 16.
  53. Chalyy M.E., Grigorjan V.A., Epifanova M.V., Krasnov A.O. The effectiveness of intracavernous autologous platelet-rich plasma in the treatment of erectile dysfunction. Urologiia. 2015;4:76-9. PMID: 26665770.
  54. Epifanova M.V. The use of autoplasma enriched with platelet growth factors in the treatment of erectile dysfunction: Ph.D. Thesis 14.01.23: 18.04.2016 Epifanova Maiya Vladimirovna. Moskva. 2016.
  55. A Study Evaluating Intraoperative Application of Platelet-Rich Plasma to the Neurovascular Bundles During Nerve-Sparing Radical Prostatectomy: Initial Technical Description and Prospective Early Postoperative Outcomes Analysis. Identifier: NCT02957149.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies