LASER THERAPY FOR MALE INFERTILITY. PART 2. SYSTEMATIC REVIEW OF CLINICAL TRIALS


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Abstract

Male infertility is a multifactorial syndrome associated with a wide range of pathological conditions affecting both the sexual and other body systems: endocrine, nervous, blood, and immune. Laser therapy is a form of modern physiotherapy that applies low-intensity laser irradiation (LILI) in various parts of the body. It is widely used in all areas of modern medicine due to its high efficiency, ease of use, the absence of contraindications and side effects. The authors reviewed the results of 171 studies investigating laser therapy, of which 93 were experimental (20 in Russian and 73 international publications), four clinical and experimental (all in Russian), 74 clinical (73 in Russian and 1 in English).Along with domestic literature, publications in Russian from Belarus, Georgia, Kyrgyzstan, Uzbekistan, and Ukraine were also reviewed. The review suggests that laser therapy should be used as much as possible in the management of male infertility not just due to high effectiveness, but also because of the lack of alternatives. For local application, optimal laser irradiation regimens are pulsed LILI of red (635 nm) and infrared (904 nm) spectra. For intravenous laser blood irradiation, the authors recommend alternating a continuous LILI with a wavelength of 635 nm (red spectrum) and 365 nm (ultraviolet spectrum).

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About the authors

O. I Apolikhin

N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology - branch of NMRRC of Minzdrav of Russia

Corr-Member of Ras, Dr.Med.Sci, Prof., Director Moscow, Russia

S. V Moskvin

The Federal State-Financed Institution “State Scientific Center of Laser Medicine under the Federal Medical Biological Agency

Email: 7652612@mail.ru
Dr.Bio.Sci., Ph.D. (tech.) The Moscow, Russia

References

  1. Hasan Р., Rijadi S.A., Purnomo S., Kainama Н. ТЪе possible application of low reactive-level laser therapy (LLLT) in the treatment of male infertility: а preliminary report. Laser Therapy. 1989;1(1):49-50.
  2. Gladkova A.I. Laser therapy in andrology. Current aspects of laser therapy. V.D. Popov, editor. Cherkassy: Vertikal’, izdatel’ Kandych S.G. 2011. Р. 448-71.
  3. Bondarenko V.A., Gladkova A.I. The efficiency of low-intensity laser therapy in male infertility of different genesis. Zdorov’ye muzhchiny. 2004;3(10):226-229.
  4. Bondarenko V.A., Burma T.Ye., Korobov A.M. The dynamics of the incremental function of the testicles under the influence of LILI in the treatment of excretory-toxic infertility in men. Proceedings of the IX International Scientific-Practical Conference «The use of lasers in medicine and biology.» Yalta-Kharkov. 1998:126-127.
  5. Vasil’yev B.C., Vasil’yeva L.I., Lisichenko N.L. et al. Interference microscopy of native and irradiated sperm of humans and animals. Proceedings of the XIX International Scientific-Practical Conference «The use of lasers in medicine and biology», Odessa. 2003:55-56.
  6. Vesich T.D., Kramar M.I. The study of the effect of laser radiation on native and post-cryopreserved human spermatozoa. Problemy kriobiologii. 1994;2:54-55.
  7. Gladkova A.I. Experimental substantiation of the effectiveness of laser therapy in andrological practice. Proceedings of the XXth International Scientific-Practical Conference «The use of lasers in medicine and biology.» Yalta. 2003:90-92.
  8. Gladkova A.I. Additive effect of drug and laser therapy for infertility. Proceedings of the XXVI International Scientific-Practical. Conference «The use of lasers in medicine and biology», Yalta. 2006:114-115.
  9. Gladkova A.I., Bondarenko V.A. Experimental-clinical justification of fertility regulation with the help of low-intensity laser irradiation. Proceedings of the XXV International Scientific-Practical Conference «The use of lasers in medicine and biology», Lutsk. 2006:79
  10. Gladkova A.I., Tarasenko N.E. The Influence of low-intensity laser irradiation on the incremental function of the testes. Proceedings of the XXI International Scientific-Practical. Conference «The use of lasers in medicine and biology», Odessa. 2004:76-77
  11. Alexandrov V.P., Korenkov D.G., Nikolaeva E.V. Advantages of the use of Androgin device for treatment of secretory infertility and chronic prostatitis. Urologiya. 2006;3:71-74
  12. Al’-Shukri S.KH., Tkachuk V.N., Sokolov A.B., Slesarevskaya M.N. Application of low-energy laser irradiation in urological diseases. Collection of scientific papers «Actual problems of laser medicine». Saint Petersburg. 2001:174-179
  13. Slesarevskaya M.N. The effectiveness of low-intensity laser radiation in patients with chronic prostatitis. Abstract of the thesis. Candidate of medical sciences. Saint Petersburg; 2004
  14. Yantareva L.I., Slesarevskaya M.N., Sokolov A.B., Kolcheva O.V. Influence of low-intensity radiation of the green and infrared spectral range on the motility of spermatozoa in chronic prostatitis. Proceedings of Int. Conf. «Problems of laser medicine». Moscow. 1997:320-321
  15. Yantareva L.I., Slesarevskaya M.N., Sokolov A.B., Kolcheva O.V. Influence of low-intensity irradiation of the green and infrared spectral range on the motility of spermatozoa in chronic prostatitis. Abstracts of the II Proceedings of the II International Symposium «Semiconductor and solid-state lasers in medicine» Saint Petersburg; 1998
  16. Al-Shukri S.H., Kuzmin I.V., Slesarevskaya M.N., Sokolov A.V. The effect of low-intensity laser radiation on semen parameters in patients with chronic prostatitis. Urologicheskiye vedomosti. 2015;5(4):8-12
  17. Mazo E.B., Siluyanov K.A. Application of low-intensity laser radiation in the complex treatment of men with secretory infertility. Farmateka. 2008;9:44-47
  18. Mazo E.B., Siluyanov K.A. The use of local low-intensity laser therapy in the complex treatment of men with secretory infertility. Andrologiya i genital’naya khirurgiya. 2009;2:101-102
  19. Siluyanov K.A. Low-intensity laser irradiation in complex treatment of patients with secretory infertility. Abstract of the thesis. Candidate of medical sciences. Moscow; 2007
  20. Siluyanov K.A. Application of low-intensity laser radiation in the complex treatment of men with secretory infertility. 2009. http://uroweb.ru/ article/db-article-3670.html
  21. Asadov Kh.D. Male infertility and the possibilities of overcoming it with the help of in vitro fertilization in hot climate. Abstract of the thesis. Doctor of medical sciences. Tashkent. 2009
  22. Vaisov I.A., Shodiyev Kh.K., Baybekov I.M. The effectiveness of low-intensity laser irradiation (LILI) in the complex treatment of infertile men. Novosti dermatologii i reproduktivnogo zdorov’ya. 2012;1:7-9.
  23. Gizinger O.A., Frantseva O.V., Zabirova M.R. A method for increasing the functional-metabolic status of spermatozoa obtained from healthy human semen in vitro and in vivo. Vestnik Chelyabinskoy oblastnoy klinicheskoy bol’nitsy. 2015;1:35-37.
  24. Gizinger O.A., Frantseva O.V. Normalizing the effects of low-intensity laser radiation in relation to the functional and metabolic status of neutrophils in semen and kinetic features of sperm in patients with chlamydial infection. Rossiyskiy immunologicheskiy zhurnal. 2016;2(1) (19):9-11.
  25. Gizinger O.A., Letyayeva O.I., Frantseva O.V. Low-intensity laser therapy in correction of motor dysfunction of spermatozoa in patients with urogenital infections. Yuzhno-Ural’skiy meditsinskiy zhurnal. 2014;3:35-41.
  26. Gizinger O.A., Letyayeva O.I., Frantseva O.V., Zabirova M.R. Application of low-intensity laser in reproductology. Vestnik Chelyabinskoy oblastnoy klinicheskoy bol’nitsy. 2014;4(27):29-33.
  27. Kalinina S.N. Inflammatory diseases of additional sex glands in men, caused by urogenital latent infection and complicated by infertility. Abstract of the thesis. Doctor of medical sciences. Saint Petersburg. 2003.
  28. Abunimekh B.Kh. Differential treatment of epididymitis and epididymorchitis. Abstract of the thesis. Candidate of medical sciences. Makhachkala. 2006.
  29. Reznikov L.L. Treatment of patients with acute epididymoorchitis with low-intensity laser radiation. Abstract of the thesis. Candidate of medical sciences. Leningrad. 1990.
  30. Safarov Sh.A. Modern approaches to the treatment of acute epididymitis. Abstract of the thesis. Candidate of medical sciences. Moscow. 2007.
  31. Shormanov I.S., Vorchalov M.M., Ryzhkov A.I. Acute epididymitis: medical and social aspects. Modern possibilities of pathogenetic therapy. Eksperimental’naya i klinicheskaya urologiya. 2012;3:71-78.
  32. Patent 2185211 RU, Int.Cl. A61N5/067. Method for treating autoimmune sterility in men. Korenkov D.G., Aleksandrov V.P., Mikhajlichenko V.V., Marusanov V.E. № 2000101244/14; Date of filling: 17.01.2000. Date of publication: 20.07.2002.
  33. Yurshin V.V. Complex treatment of chronic prostatitis using a low-energy laser. Abstract of the thesis. Candidate of medical sciences. Moscow. 1998.
  34. Yurshin V.V. Magnetic laser therapy in the treatment of male infertility. National medical booklet. Moscow: Izdatel’skaya gruppa «BDTS-Press». 2003; 2(3):171-173.
  35. Yurshin V.V. Excretory-inflammatory form of male infertility (pathogenesis, diagnosis, treatment). Abstract of the thesis. Doctor of medical sciences. Moscow. 2006.
  36. Yurshin V.V., Sergienko N.F., Illarionov V.E. Ethiopathogenetic validation of using magnetolaser therapy in combined treatment of male infertility. Urologiya. 2003;2:23-25.
  37. Ikhayev A.B. Combined use of magnetolaser and LD-laser therapy of infertility in patients with chronic prostatitis. Abstract of the thesis. Candidate of medical sciences. Pyatigorsk. 2013.
  38. Ivanchenko L.P., Kozdoba A.S., Moskvin S.V. Laser therapy in urology. Moscow-Tver’: OOO «Izdatel’stvo «Triada». 2009.
  39. Moskvin S.V., Ivanchenko L.P. Backgroundings for the technique of local laser negative pressure. Lazernaya meditsina. 2014;18(3):21-26.
  40. Moskvin S.V., Ivanchenko L.P. Chronobiological approach to the treatment of patients with erectile dysfunction using a combination of local negative pressure and laser illumination. Urologiya. 2014;3:48-
  41. Putilin V.A. Endovascular laser and balneotherapy combined with laser acupuncture in complex treatment of infertility in patients with chronic prostatitis. Abstract of the thesis. Candidate of medical sciences. Pyatigorsk. 2009.
  42. Tereshin A.T., Putilin V.A., Mashnin V.V., Morozov F.A. Laserotherapy of fertile disturbances in patients with chronic prostatitis. Vestnik novykh meditsinskikh tekhnologiy. 2007;14(4):208
  43. Tereshin A.T., Putilin V.A., Mashnin V.V., Morozov F.A. Laserotherapy atdisorders of fertility in the patients with chronic prostatitis. Vestnik novykh meditsinskikh tekhnologiy. 2008; 15(4): 121
  44. Agayev A.A. The use of acu- and laser puncture in combination with balneo and peloid therapy in men with impaired fertility caused by nonspecific inflammatory diseases of the genital organs. Thesis. Doctor of medical sciences. Pytigorsk. 1998
  45. Ikhayev A.B., Teroshin A.T. Laser therapy, acu- and laser puncture in correction of infertility in patients with chronic prostatitis. Proceedings of the VII Internatioal Congress PAAR. Sochi. 2012. С. 25
  46. Tereshin A.T., Istoshin N.G., Putilin V.A., Merslikin N.V. Combined use of the laserotherapy, acu- and laseropuncture in correction of infertility in patients with chronic prostatitis. Vestnik novykh meditsinskikh tekhnologiy. 2008; 15(4): 158-160
  47. Tereshin A.T., Istoshin N.G., Putilin V.A., Mashnin V.V. Balneo-, laserotherapy, acu- and laseropuncture in correction in infertility in patients with chronic prostatitis. Vestnik novykh meditsinskikh tekhnologiy. 2009;16(1):74-77
  48. New medical technology FS № 2008/234 from 07.11.2008. Combined use of endovascular laser therapy, acu- and laser puncture in correction of infertility in patients with chronic prostatitis. Pyatigorsk State Scientific Research Institute of Balneology. Moscow. 2008.
  49. Satybaldyyev Sh.R. Medical rehabilitation of patients with chronic prostatitis with reproductive dysfunction. Abstract of the thesis. Candidate of medical sciences. Bishkek. 2000.
  50. Satybaldyev Sh.R., Satybaldyev E.Sh., Evdokimov V.V. Rehabilitation reproductive function in patients in official infertile marriages. Andrologiya i genital’naya khirurgiya. 2013;14(4):69-72.
  51. Satibaldiev Sh.R., Satibaldiev E.Sh., Evdokimov V.V. Treatment of the patients with chronic abacterial prostatitis and fertility disturbances. Eksperimental’naya i klinicheskaya urologiya. 2014;4:43-46.
  52. Moskvin S.V., Borisova O.N., Belyaeva E.A. Intravenous laser blood fluoring. Klinicheskaya meditsina i farmakologiya. 2017;3(1):21-25.
  53. Slonimsky B.Yu. Features of the blood supply to the penis in the patients with obesity and reproductive dysfunction at the use of the developed complex program and its individual components. Vestnik novykh meditsinskikh tekhnologiy. Elektronnoye izdaniye. 2013; 1:155.
  54. Slonimskiy B.Yu. Modern programs for the restoration of reproductive function in obese men. Abstract of the thesis. Doctor of medical sciences. M., 2013.
  55. Slonimsky B.Yu., Kotenko K.V., Schukin A.I. Innovative technologies of vegetative correction in the treatment of patients with obesity and reproductive dysfunction. Vestnik novykh meditsinskikh tekhnologiy. Elektronnoye izdaniye. 2013; 1: 156.
  56. Mufaged M.L., Tirsi K.A., Siluyanov K.A., Novitskiy V.Ye. Application of low-intensity laser irradiation in the treatment of infertile patients with varicocele. Vestnik Rossiyskogo gosud. univ. (special issue). 2004;2(33):17.
  57. Patent 8413 BY, Int.Cl. A61N5/01, 5/067. Method for improving the quality of sperm production in breeding boars. I.P. Sheyko, Yu.A. Gorbunov, A.I. Budevich, D.V. Yeliseykin. № a 20020964; Date of filling: 29.11.2002. Date of publication. 30.09.2003.
  58. Patent 62075 UA, Int.Cl. A61N5/067. Method for treating patients with pathology of spermatogenesis. V.K. Chayka, V.P. Kvashenko, O.I. Ostapenko. № 2002087031; Date of filling: 28.08.2002. Date of publication: 15.12.2003. (In Ukrain.)
  59. Patent 2205047 RU, Int.Cl. A61N5/067. Method for improving sperm quality in the cases of pathospermia applicable in artificial fertilization program. Yu.A. Gavrilov, L.N. Kuz’michev, B.V. Leonov, T.N. Levchuk. № 2001119656/14; Date of filling: 18.07.2001. Date of publication: 27.05.2003.
  60. Patent 2294779 RU, Int.Cl. A61N 5/06, A61H 19/00. Method for treating autoimmune male infertility cases. S.N. Kalinina, O.L. Tiktinskiy, V.P. Aleksandrov et al. № 2005122529/14; Date of filling: 15.07.2005. Date of publication: 10.03.2007.
  61. Patent 2406549 RU, Int.Cl. A61N 5/067, A61K 31/355, A61K 31/07, A61P 15/08. Method of complex spermatogenesis stimulation. V.M. Chekmarev, I.V. Kharchenko, A.E. Mashkov. № 2009139823/14; Date of filling: 28.10.2009. Date of publication: 20.12.2010.
  62. Patent 2418581 RU, Int.Cl. A61K 31/138, A61K 33/18, A61K 35/24, A61P 15/08, A61N 5/06. Application of musk deer musk tincture and ultraviolet irradiation of blood for treatment of spermatogenic failure in men of reproductive age. E.Yu. Zagarskikh, L.I. Kolesnikova, V.V. Dolgikh et al. № 2010103786/15; Date of filling: 04.02.2010. Date of publication: 20.05.2011.
  63. Patent 2481132 RU, Int.Cl. A61N 5/06. Method of experimental stimulation of spermatogenesis. T.G. Shcherbatyuk, Ya.S. Novikova, V.V. Chernov. № 2011147987/14; Date of filling: 24.11.2011. Date of publication: 10.05.2013.
  64. Patent 2583949 RU, Int.Cl. A61N5/067. Method of increasing functional-metabolic status of sperm cells obtained from semen of healthy individual in vitro under effect of low-intensity laser. O.A. Gizinger, I.I. Dolgushin, O.V. Frantseva, E.L. Kurenkov. № 2015103290/14; Date of filling: 02.02.2015. Date of publication: 10.05.2016.
  65. Avdoshin V.P. et al. Magnetic laser therapy for chronic prostatitis. Proceedingds of the Plenum of the All-Russian Society of Urology. Perm’. 1994:12-13.
  66. Laser therapy in medical rehabilitation and prevention programs: clinical guidelines. FSBI «Russian Scientific Center for Medical Rehabilitation and Balneology» Ministry of Health of Russia, FSBI «State Scientific Center of Laser Medicine of FMBA of Russia». Gerasimenko M.YU., Geynits A.V., Moskvin S.V. et al. Moscow; 2015.
  67. Moskvin S.V., Kisselev S.B. Laser therapy for joint and muscle pain. Moscow- Tver’: OOO «Izdatel’stvo Triada». 2017.

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