Balloon dilation treatment of primary obstructive megaureter in children

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Abstract

Purpose: Investigation of the results of ureteral stricture single balloon dilation in children with primary obstructive megaureter.

Materials and methods. Since 2012 to 2020 79 children (65 boys and 15 girls) with primary obstructive megaureter of II and III grades who had 92 affected ureters were operated on by method of ureteral stricture balloon dilation. Duration of postoperative stenting period was Me=68 [48; 91] days, bladder catheterization period – Me=15 [5; 61] days. Follow-up was from 1 to 10 years.

Results. There were no intraoperative complications in the group of investigation. Pyelonephritis exacerbation in the early postoperative period occurred in 15 cases (18,98%). Control comprehensive examination revealed that urodynamics of 63 children (79,74%) tended to normalization what persisted in the future. There was no positive dynamics in 16 cases (20,25%). Vesico-ureteral reflux was revealed in 4 cases.

Discussion. Assessment of impact of various predictors (passport, urodynamic, infectious, anatomic, operation and postoperative period characteristics) on the treatment results proved that the effectiveness of the procedure depends on the following factors: ureteral stricture length (M-U Test U=202,5 p=0,0002) and

features of the stricture rapture during ballooning (Fisher exact p=0,0006). There was significant difference in results in the group of up to 10 mm inclusive stricture length and the longer stricture group (Fisher exact p=0,00001). High activity of pyelonephritis in postoperative period was the predictor of adverse outcome (Fisher exact p=0,00001).

Conclusion. Practically 80% of children with primary obstructive megaureter may be reliably cured by the method of ureteral stricture balloon dilation. The risk of intervention failure is greatly increased in case of the stricture length is more than 10 mm and technical difficulties of ballooning indicating a high resistance of the narrowed portion of the ureter to dilation.

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About the authors

D. A. Lebedev

Federal State Budget Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of Russian Federation

Author for correspondence.
Email: Urolog.Lebedev@gmail.com
ORCID iD: 0000-0003-4078-5116

Cand.Med.Sci., MD, PhD, associate professor Urology Department’s 

Russian Federation, Saint-Petersburg

I. B. Osipov

Federal State Budget Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of Russian Federation

Email: osipovnir@mail.ru
ORCID iD: 0000-0002-1170-3436

Doctor Med.Sci., MD, PhD, professor, Urology Department’s Head

Russian Federation, Saint-Petersburg

M. I. Komissarov

Federal State Budget Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of Russian Federation

Email: angio.gpma@gmail.com
ORCID iD: 0000-0003-4788-7561

Cand.Med.Sci., MD, PhD, associate professor, Cardiovascular surgery Department’s

Russian Federation, Saint-Petersburg

S. A. Sarychev

Federal State Budget Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of Russian Federation

Email: serg_sarychev@mail.ru
ORCID iD: 0000-0002-8723-2976

Cand.Med.Sci., MD, PhD, children surgeon-urologist Urology Department’s

Russian Federation, Saint-Petersburg

L. A. Alekseeva

Federal State Budget Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of Russian Federation

Email: k2madicin@yandex.ru
ORCID iD: 0000-0003-1006-828X

Cand. Med. Sci., MD, PhD, associate professor Urology Department’s

Russian Federation, Saint-Petersburg

M. V. Lifanova

Federal State Budget Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of Russian Federation

Email: maria.lifanova@mail.ru
ORCID iD: 0000-0003-1626-7255

assistant professor Urology Department’s

Russian Federation, Saint-Petersburg

N. V. Nesterova

Federal State Budget Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of Russian Federation

Email: natalya-spring@mail.ru
ORCID iD: 0000-0002-0296-1126

senior laboratory assistant Urology Department’s

Russian Federation, Saint-Petersburg

References

  1. Yushko E.I. Megaureter in children: terminology, classification, clinic, diagnisis, treatment. Vestnik VGMU. 2006;5(4):65–71. Russian (Юшко Е.И. Мегауретер у детей: терминология, классификация, клиника, диагностика, лечение. Вестник ВГМУ. 2006;5(4):65–71).
  2. Anheuser P., Kranz J., Steffens J., Beetz R. [Primary megaureter]. Urologe A. 2013;52(1):33–38. doi: 10.1007/s00120-012-3081-5.
  3. Dubrov V.I., Bondarenko S.G. Laparoscopic ureteral reimplantation in megaureter’s treatment in children. Medical journal. 2018(2):47–51. Russian (Дубров В.И., Бондаренко С.Г. Лапароскопическая реимплантация мочеточника при лечении мегауретера у детей. Медицинский журнал. 2018(2):47–51).
  4. Shamsiev A.M., Daniyarov E.S., Babanin I.L., Shamsiev Zh. A. Effectiveness of endoscopic treatment of obstructive uropathies in children. Children surgery. 2012(4):4–6. Russian (Шамсиев А.М., Данияров Э.С., Бабанин И.Л., Шамсиев Ж.А., Ибрагимов Ш.Ш. Эффективность эндохирургического лечения обструктивных уропатий у детей. Детская хирургия. 2012(4):4–6).
  5. Gubarev V.I., Zorkin S.N., Sal’nikov V. Yu., Filinov I.V., Petrov E.I., Malikov Sh.G. at al. Effectiveness of high pressure balloon dilatation in obstructive uropathies treatment in children. Pediatriya. J. named G.N. Speransky. 2017;96(5):152–156. doi: 10.24110/0031-403X-2017-96-5-152-156. Russian (Губарев В.И., Зоркин С.Н., Сальников В.Ю., Филинов И.В., Петров Е.И., Маликов Ш.Г. и др. Эффективность баллонной дилатации высокого давления при лечении обструктивных уропатий у детей. Педиатрия. Журнал им. Г.Н. Сперанского. 2017;96(5):152–156. doi: 10.24110/0031-403X-2017-96-5-152-156).
  6. Pingoud E.G., Bagley D.H., Zeman R.K., Glancy K.E., Pais O.S. Percutaneous antegrade bilateral dilation and stent placement for internal drainage. Radiology. 1980;134(3):780. doi: 10.1148/radiology.134.3.7355234.
  7. Angerri O., Caffaratti J., Garat J.M., Villavicencio H. Primary obstructive megaureter: initial experience with endoscopic dilatation. J Endourol. 2007;21(9):999–1004. doi: 10.1089/end.2006.0122.
  8. Osipov I.B., Lebedev D.A. Miniinvasive treatment of obstructive megaureter in children. Thesises of III Congress children urologist-andrologist (Moscow, 20-21 apr. 2013). Russian (Осипов И.Б., Лебедев Д.А. Малоинвазивное лечение обструктивного мегауретера у детей. Материалы III съезда детских урологов-андрологов (Москва, 20–21 апреля 2013 г.). 2013:115).
  9. Sal’nikov V.Yu., Gubarev V.I., Zorkin S.N., Filinov I.V., Petrov E.I. Endoscopic high pressure balloon dilatation as treatment method of primery obstructive megaureter in children. Pediatriya. J. named G.N. Speransky. 2016;95(5):48–52. Russian (Сальников В.Ю., Губарев В.И., Зоркин С.Н., Филинов И.В., Петров Е.И. Эндоскопическая баллонная дилатация высокого давления как метод лечения первичного обструктивного мегауретера у детей. Педиатрия. Журнал им. Г.Н. Сперанского. 2016;95(5):48–52).
  10. Capozza N., Torino G., Nappo S., Collura G., Mele E. Primary obstructive megaureter in infants: our experience with endoscopic balloon dilation and cutting balloon ureterotomy. J Endourol. 2015;29(1):1–5. doi: 10.1089/end.2013.0665.
  11. García-Aparicio L., Blázquez-Gómez E., Martin O., Palazón P., Manzanares A., García-Smith N., et al. Use of high-pressure balloon dilatation of the ureterovesical junction instead of ureteral reimplantation to treat primary obstructive megaureter: is it justified? J Pediatr Urol. 2013;9(6 Pt B):1229–1233. doi: 10.1016/j.jpurol.2013.05.019.
  12. Bujons A., Saldaña L., Caffaratti J., Garat J.M., Angerri O., Villavicencio H. Can endoscopic balloon dilation for primary obstructive megaureter be effective in a long-term follow-up? J Pediatr Urol. 2015;11(1):37.e1-6. doi: 10.1016/j.jpurol.2014.09.005
  13. Chiarenza S.F., Bleve C., Zolpi E., Battaglino F., Fasoli L., Bucci V. Endoscopic balloon dilatation of primary obstructive megaureter: method standardization and predictive prognostic factors. Pediatr Med Chir. 2019;41(2):25–28. doi: 10.4081/pmc.2019.219.
  14. Gladin D.P., Lifanova M.V., Lebedeva N.D. Urine microflora and severity of infection in children with surgical pathology. Forcipe. 2019;2(3):3–13. Russian (Гладин Д.П., Лифанова М.В., Лебедева Н.Д. Микрофлора мочи и тяжесть инфекции у детей с хирургической патологией. Forcipe. 2019;2(3):3–13).
  15. Zorkin S.N., Galuzinskaya A.T., Filinov I.V., Petrov E.I. Prognostic factors of the effectiveness high pressure balloon dilatation in primary obstructive megaureter in children of early age. Thesises of X anniversary Russian children urology and andrology School. Moscow, «Uromedia-Press». 2022:11–1–2. Russian (Зоркин С.Н., Галузинская А.Т., Филинов И.В., Петров Е.И. Прогностические факторы эффективности баллонной дилатации высокого давления при первичном обструктивном мегауретере у детей раннего возраста. Х Юбилейная Всероссийская Школа по детской урологии-андрологии. Сборник тезисов. Москва, ИД «Уромедиа». 2022:11–12).
  16. Galuzinskaya A.T., Zorkin S.N. Endoscopic balloon dilatation of primary obstructive megaureter in children: standartisation of method and prognostic mean factors. Russian pediatric journal. 2021;24(S):16–17. Russian (Галузинская А.Т., Зоркин С.Н. Эндоскопическая баллонная дилатация при первичном обструктивном мегауретере у детей: стандартизация метода и прогностически значимые факторы. Российский педиатрический журнал. 2021;24(S):16–17).
  17. Lolaeva B.M., Dzheliev I.Sh. Results of conservative, endoscopic, surgery methods of treatment obstructive magaureter in early-age children. Vestnik VolgGMU. 2020;73(1):169–172. Russian (Лолаева Б.М., Джелиев И.Ш. Результаты консервативного, эндоскопического, хирургического методов лечения обструктивного мегауретера у детей раннего возраста. Вестник ВолгГМУ. 2020;73(1):169–172).
  18. Zuban’ O.N., Skornyakov S.N., Borodin E.P., Novikov B.I., Medvinskiy I.D., Arkanov L.V. et al. Endoscopic methods of ureteral strictures correction. Urology. 2013(3):57–60. Russian (Зубань О.Н., Скорняков С.Н., Бородин Э.П., Новиков Б.И., Медвинский И.Д., Арканов Л.В. и др. Эндоскопические методы коррекции стриктур мочеточника. Урология. 2013(3):57–60).
  19. Osipov I.B., Lebedev D.A. Balloon dilation of ureteral stricture for obstructive megaureter in children. Pediatrician. 2016;7(S):207–208. Russian (Осипов И.Б., Лебедев Д.А. Баллонирование стриктуры мочеточника при обструктивном мегауретере у детей. Педиатр. 2016;7(S):207–208).
  20. Smeulders N., Yankovic F., Chippington S., Cherian A. Primary obstructive megaureter: cutting balloon endo-ureterotomy. J Pediatr Urol. 2013;9(5):692.e1–2. doi: 10.1016/j.jpurol.2013.04.010.
  21. Romero R.M., Angulo J.M., Parente A., Rivas S., Tardáguila A.R. Primary obstructive megaureter: the role of high pressure balloon dilation. J Endourol. 2014;28(5):517–523. doi: 10.1089/end.2013.0210.
  22. García-Aparicio L., Blázquez-Gómez E., de Haro I., Garcia-Smith N., Bejarano M., Martin O., et al. Postoperative vesicoureteral reflux after high-pressure balloon dilation of the ureterovesical junction in primary obstructive megaureter. Incidence, management and predisposing factors. World J Urol. 2015;33(12):2103–2106. doi: 10.1007/s00345-015-1565-9

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. Changing the shape of the balloon tip during dilation of the ureteral stricture: forming a waist band (A), straightening the waist when the stricture breaks (B)

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3. Fig. 2. Excretory urograms of a patient with a grade 3 megaureter before (A) and 17 months after (B) balloon dilation

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4. Fig. 3. Results of stricture dilation depending on the length of the stricture as a whole (A) and with strictures up to 10 mm and 10 mm or more (B)

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5. Fig. 4. Treatment results depending on the nature of the rupture of the structure (A) and the activity of infection after removal of the stent (B).

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