Modern methods for determining the positive surgical margin during radical prostatectomy

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Abstract

Determining and evaluation of predictors of biochemical recurrence (BCR) is one of the essential aim, which may help to achieve the most effective treatment of prostate cancer. Obviously, positive surgical margins represent an independent risk factor for BR following radical prostatectomy. The development of methods determining the status of the surgical margin during surgery is an important direction which can upgrade the effectiveness of prostate cancer treatment. Moreoverit is relevant to review modern methods for diagnosing the status of the surgical margin during radical prostatectomy.

This article presents a systematic review carried out at the Department of Urology and Andrology of Pirogov Russian National Research Medical University. In September 2021, we performed a PubMed/Web of Science search to include articles published in 1995–2020 evaluating the key words «prostate cancer», «surgical margin», «radical prostatectomy», «biochemical recurrence», «methods for determining the surgical margin». Nowadays the following technologies have been developed and being actively studied: the usage of aminolevulinic acid, optical coherence tomography, optical spectroscopy, confocal laser microscopy, 3D augmented reality, 3D modeling, the study of frozen samples.

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About the authors

I. S. Byadretdinov

Pirogov Russian National Research Medical University

Author for correspondence.
Email: byadretdinov.i@gmail.com
ORCID iD: 0000-0002-1275-2133

postgraduate at the Department of Urology and Andrology

Russian Federation, Moscow

S. V. Kotov

Pirogov Russian National Research Medical University; N.I. Pirogov City Clinical Hospital № 1 of the Moscow Healthcare Department

Email: urokotov@mail.ru
ORCID iD: 0000-0003-3764-6131

MD, professor, head of Department of Urology and Andrology

Russian Federation, Moscow; Moscow

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2. Fig.1. Micro-preparation of acinar adenocarcinoma 3+3 by Gleason. Magnification of 20X.

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3. Fig. 2. Micro-preparations of acinar adenocarcinoma. The relationship between histological examination and the sensitivity of photodynamic diagnostics. Magnification 20X

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4. Fig. 3. Micro-preparations of acinar adenocarcinoma. Magnification 20X

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5. Fig. 4. The principle of operation of confocal laser microscopy in the diagnosis of bladder cancer

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