Organ-sparing treatment of prostate stromal tumor of uncertain malignancy potential

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

A case of organ-preserving treatment of prostate stromal tumor with an uncertain malignancy potential is presented in the article. The patient underwent laparoscopic resection of the prostate neoplasm. Mesenchymal prostate tumors are rare. Their diagnosis is difficult due to the lack of experience of both pathologists and urologists. Mesenchymal neoplasms include prostate stromal tumors of uncertain malignant potential. Due to the rare occurrence of these tumors and the difficulties of its diagnosis, there is no recommended treatment algorithm. Taking into account the anatomical location of the tumor, the patient underwent enucleoresection without removing the entire prostate. The control examination, including pelvic MRI, was carried out after 3 months. There were no signs of disease progression. The presented clinical case of prostate preservation during resection of a prostate stromal tumor of uncertain malignancy potential demonstrates a possibility of organ-preserving procedures in such a rare disease. However, due to a small number of publications and a short follow-up period, these tumors require further study and evaluation of long-term results.

Full Text

Restricted Access

About the authors

V. S. Boshchenko

FGBOU VO Siberian State Medical University of the Ministry of Healthcare of the Russian Federation

Email: vsbosh@mail.ru

Ph.D., MD, professor of the Department of General and Pediatric Urology and Andrology

Russian Federation, Tomsk

D. A. Maspanov

FGBOU VO Siberian State Medical University of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: maspanov.da@ssmu.ru

assistant at the Department of General and Pediatric Urology and Andrology, urologist of the Urologic Department of Hospital Surgery Clinics

Russian Federation, Tomsk

M. S. Lozovsky

FGBOU VO Siberian State Medical University of the Ministry of Healthcare of the Russian Federation

Email: mslozovskij@gmail.com

Ph.D., Head of the Urologic Department of Hospital Surgery Clinics

Russian Federation, Tomsk

E. D. Kuchina

FGBOU VO Siberian State Medical University of the Ministry of Healthcare of the Russian Federation

Email: katya.kuchina.97@mail.ru

resident at the Department of General and Pediatric Urology and Andrology

Russian Federation, Tomsk

M. V. Zavyalova

FGBOU VO Siberian State Medical University of the Ministry of Healthcare of the Russian Federation

Email: zavyalova.mv@ssmu.ru

Ph.D., MD, professor, Head of the Department of Pathology

Russian Federation, Tomsk

References

  1. Frank G.A., Andreeva Y.Y., Moskvina L.V., et. al. Novaya klassifikatsiya VOZ opukholeipredstatel’noizhelezy [A new WHO classification of prostate tumors]. ArkhPatol. 2016;78(4):32–42. Russian. doi: 10.17116/patol201678432-42.
  2. Fabio T., Oleksandr N.K., Jonathan I. Epstein,Mesenchymal tumours of the bladder and prostate: an update. Pathology,Volume 45, Issue 2,2013,Pages 104-115, ISSN 0031-3025. doi: 10.1097/PAT.0b013e32835c768b.
  3. De Berardinis E., Busetto G.M., Antonini G., et. al. Incidental prostatic stromal tumor of uncertain malignant potential (STUMP): histopathological and immunohistochemical findings. Urologia. 2012;79(1):65–68. doi: 10.5301/RU.2012.9099.
  4. Fukuhara S., Matsuoka Y., Hanafusa T., et. al. [A case report of prostatic stromal tumor of uncertain malignant potential (STUMP)]. Hinyokika Kiyo. 2008; 54(5):377–381. Japanese. PMID: 18546866.
  5. Herawi M., Epstein J.I. Specialized stromal tumors of the prostate: a clinicopathologic study of 50 cases. Am J SurgPathol. 2006;30(6):694–704. doi: 10.1097/00000478-200606000-00004.
  6. Yang W., Liu A., Wu J., Niu M. Prostatic stromal sarcoma: A case report and literature review. Medicine (Baltimore). 2018;97(18):e0495. doi: 10.1097/MD.0000000000010495.
  7. McKenney J. Mesenchymal tumors of the prostate. Mod Pathol. 2018;31:133–142. doi: 10.1038/modpathol.2017.155

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig.1. MRI data of the pelvic organs with contrast in the sagittal (A), axial (B) and coronal (C) projections before surgery: in the transient zone of the left lobe of the pancreas, an ovoid cystic-solid formation was determined., 58x52x50 mm in size, with areas of cystic restructuring and hemorrhages; in the left parts of the mass, there is an area of homogeneous, moderately reduced MR signal, irregular in shape, with signs of diffusion limitation and diffuse accumulation of the contrast agent, without signs of extracapsular extension (PIRADS 4)

Download (353KB)
3. Fig.2. Stages of the operation: A - The intrapelvic fascia was opened, the anterior surface of the neoplasm was exposed, to the right of the instrument, the prostate gland; B - Dissection of tissues, a layer between the formation and the pancreas; B - Cutting off the last fixing tissues with LigaSure (COVIDIEN); D - view after removal of the formation. O - education, MP - bladder.

Download (514KB)
4. Fig.3. Histological presentation of a stromal tumor with uncertain malignancy potential. Stained with hematoxylin and eosin. A - formation of a nodule without a capsule (shown by arrows). x1.5; B - fibrous stroma, fusiform and polymorphic tumor cells. x10; B - polymorphic tumor cells with degenerative changes in chromatin. x20.

Download (461KB)
5. Fig.4. MRI data of the pelvic organs with contrast in the sagittal (A), axial (B) and coronal (C) projections after surgery: MRI signs of postoperative cicatricial fibrous changes along the postero-left surface of the pancreas, covering the pubococcygeal muscle, lateral pubic cystic ligament and left seminal vesicle

Download (363KB)

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies