Urothelial morphological study for differential diagnosis of chronic recurrent lower urinary tract infection
- Authors: Ibishev K.S.1, Todorov S.S.1, Ismailov R.S.1, Mamedov V.K.1, Kogan M.I.1
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Affiliations:
- Rostov State Medical University
- Issue: No 5 (2023)
- Pages: 16-21
- Section: Original Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/625307
- DOI: https://doi.org/10.18565/urology.2023.5.16-21
- ID: 625307
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Abstract
Introduction. Chronic recurrent cystitis (CRC), notwithstanding the advancements of up-to-date uroinfectology, remains an urgent and controversial problem. An important section of this issue is the study of the etiology of the disease, the determination of which defines the success of treatment and the planned scope of prophylaxis.
Objective. To study pathomorphological changes in the bladder urothelium of patients with chronic recurrent cystitis depending on the etiological factor.
Materials and methods. One hundred fifty eight sexually active female patients aged 20–45 years who had previously been diagnosed with recurrent lower urinary tract infection / chronic recurrent cystitis (RLUTI / CRC) during exacerbation were included in this prospective study. Based on the results of bacteriological and PCR studies of urine, urethral and vaginal discharge, patients were divided into four groups depending on the dominant etiological factor (bacteria / HPV / Candida spp. / M. tuberculosis). Bladder biopsy was performed in remission stage of the disease after premedication and general anaesthesia as routine during cystoscopy. Biopsy specimens after standard preparation were subjected to histological study with characterisation of the changes.
Results. The histological study results revealed characteristic specific pathomorphological tissue changes in different groups, which allowed us to define a protocol for differential diagnosis of RLUTI.
Conclusions. One of the guiding methods of differential diagnostics of RINMP / CRC defining the genesis of infectious-inflammatory process in the bladder is histological study of its biopsy specimens.
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About the authors
Kh. S. Ibishev
Rostov State Medical University
Author for correspondence.
Email: Ibishev22@mail.ru
ORCID iD: 0000-0002-2954-842X
M.D., Dr.Sc.(Med), Full Prof., Prof., Dept. of Urology, Pediatric Urology & Reproductive Health
Russian Federation, Rostov-on-DonS. S. Todorov
Rostov State Medical University
Email: sertodorov@gmail.com
ORCID iD: 0000-0001-8476-5606
Dr.Sc.(Med), Assoc.Prof.(Docent), Head, Dept. of Pathology
Russian Federation, Rostov-on-DonR. S. Ismailov
Rostov State Medical University
Email: dr.ruslan.ismailov@gmail.com
ORCID iD: 0000-0003-1958-9858
M.D., Cand.Sc.(Med); Assist.Prof., Dept. of Urology, Pediatric Urology & Reproductive Health
Russian Federation, Rostov-on-DonV. K. Mamedov
Rostov State Medical University
Email: mamedov1007@yandex.ru
ORCID iD: 0000-0001-5508-4510
M.D., Urologist, Postgraduate student, Dept. of Urology, Pediatric Urology & Reproductive Health
Russian Federation, Rostov-on-DonM. I. Kogan
Rostov State Medical University
Email: dept_kogan@mail.ru
ORCID iD: 0000-0002-1710-0169
M.D., Dr.Sc.(Med), Full Prof., Honored Scientist of the Russian Federation, Head, Dept. of Urology, Pediatric Urology & Reproductive Health
Russian Federation, Rostov-on-DonReferences
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