The possibility of correcting oxidative stress in patients with inflammatory type of chronic abacterial prostatitis (chronic pelvic pain syndrome category IIIA)

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Abstract

Introduction. The term «chronic prostatitis» includes many different symptomatic patterns, many aspects of which still remain a mystery. The role of oxidative stress in the pathophysiology of many diseases, including prostatitis, is undisputable.

Aim. To evaluate the capabilities of a mineral-vitamin antioxidant complex for the treatment of patients with chronic abacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Material and methods. A total of 47 patients with inflammatory type of chronic abacterial prostatitis/chronic pelvic pain syndrome (CPPS) were included in the study. The examination, along with standard tests, included evaluation of the antioxidant status. Patients were randomized into the main group (n=26), and the control group (n=21). All men received standard therapy. However, in the main group, Selzinc-plus was additionally prescribed, 2 tablets per day for 2 months. The results were assessed after 2 months of therapy.

Results. Standard therapy had a significant effect in patients of both groups, which lasted for two months. However, additional antioxidant therapy practically doubled this effect on the symptom scale, although it had no influence on the number of leukocytes in the expressed prostate secretions. At baseline, all patients in both groups had a decrease in antioxidant protection. Two months of taking Selzinc-plus led to normalization of the overall antioxidant status. In the control group, there was also a positive trend in antioxidant status, but significant differences were obtained only in the activity of erythrocyte superoxide dismutase.

Conclusion. CP/CPPS is accompanied by oxidative stress. Taking Selzinc-plus for two months allows to restore the activity of the antioxidant system.

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About the authors

S. Yu. Shevchenko

Policlinics No26

Author for correspondence.
Email: urotub@yandex.ru

Ph.D., urologist

Russian Federation, Novosibirsk

E. V. Kulchavenya

Novosibirsk State Medical University of Ministry of Health of Russia; Privolzhsky Research Medical University of the Ministry of Health of the Russia; Medical Center “Avicenna”

Email: urotub@yandex.ru

Ph.D., MD, professor, professor at Department of Phthisiopulmonology, professor at the Department of Urology named after E.V. Shakhov, Scientific Chief

Russian Federation, Novosibirsk; Nizhny Novgorod; Novosibirsk

А. А. Baranchukova

Novosibirsk State Medical University of Ministry of Health of Russia

Email: koshka.70@mail.ru

Ph.D., associate professor of the Department of Phthisiopulmonology

Russian Federation, Novosibirsk

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