The efficiency of pre-administration of a peptide mimicking the spatial structure of erythropoietin α-chain B in modeling experimental post-contrast acute kidney injury
- 作者: Bratchikov O.I.1, Kondrashov М.М.1, Kostina D.A.2, Shcheblykina O.V.2
-
隶属关系:
- Kursk State Medical University of the Ministry of Health of the Russian Federation
- Belgorod National Research University
- 期: 编号 6 (2023)
- 页面: 64-67
- 栏目: Original Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/626069
- DOI: https://doi.org/10.18565/urology.2023.6.64-67
- ID: 626069
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
详细
Aim. To study the efficiency of pre-administration of a peptide mimicking the spatial structure of erythropoietin α-chain B in modeling experimental post-contrast acute kidney injury.
Materials and methods. In this study, an experimental model of post-contrast acute kidney injury was created using a non-steroidal anti-inflammatory drug, a nitric oxide synthase inhibitor, and injection of iopromide to mature male mice. After 48 hours, a comprehensive assessment of the concentration of creatinine, urea, glomerular filtration rate, the ratio of urea/albumin in the serum, as well as the level of proteinuria and interleukin 6 in the urine was carried out.
Results. A peptide mimicking the spatial structure of erythropoietin α-chain B, administered at a dose of 100 μg/kg 30 minutes before modeling of pathologic process, contributes to a significant decrease in creatinine and urea concentrations by 2.5 and 1.8 times, respectively, with an increase in glomerular filtration rate 4.4 times. In addition, in the group with pharmacological correction, there was a significant decrease in the ratio of urea/albumin by 2.2 times, a decrease in the level of proteinuria by 61.9% and a decrease in the concentration of pro-inflammatory interleukin-6 in the urine by 2.1 times.
Conclusion. Thus, the preliminary administration of a peptide that mimics the spatial structure of the erythropoietin α-chain B helps to reduce the severity of post-contrast acute kidney injury in the experiment, due to anti-inflammatory properties.
全文:
作者简介
O. Bratchikov
Kursk State Medical University of the Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: BratchikovOI@kursksmu.net
Ph.D., MD, Head of the Department of Urology
俄罗斯联邦, KurskМ. Kondrashov
Kursk State Medical University of the Ministry of Health of the Russian Federation
Email: Kondra.0317@mail.ru
ORCID iD: 0009-0007-1479-3557
Assistant of the Department of Urology
俄罗斯联邦, KurskD. Kostina
Belgorod National Research University
Email: daria-f13@mail.ru
ORCID iD: 0000-0002-4505-3988
Ph.D., Associate Professor of the Department of Pharmacology and Clinical Pharmacology
俄罗斯联邦, BelgorodO. Shcheblykina
Belgorod National Research University
Email: sheolvi31@gmail.com
ORCID iD: 0000-0003-0346-9835
Ph.D., Associate Professor of the Department of Pharmacology and Clinical Pharmacology
俄罗斯联邦, Belgorod参考
- van der Molen A.J., Reimer P., Dekkers I.A., Bongartz G, Bellin M.F., Bertolotto M., Clement O., Heinz-Peer G., Stacul F., Webb J.A.W., Thomsen H.S. Post-contrast acute kidney injury – Part 1: Definition, clinical features, incidence, role of contrast medium and risk factors : Recommendations for updated ESUR Contrast Medium Safety Committee guidelines. Eur Radiol. 2018;28(7):2845–2855. doi: 10.1007/s00330-017-5246-5. Epub 2018 Feb 9.
- van der Molen A.J., Reimer P., Dekkers I.A., Bongartz G, Bellin M.F., Bertolotto M., Clement O., Heinz-Peer G., Stacul F., Webb J.A.W., Thomsen H.S. Post-contrast acute kidney injury. Part 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients: Recommendations for updated ESUR Contrast Medium Safety Committee guidelines. Eur Radiol. 2018;28(7):2856–2869. doi: 10.1007/s00330-017-5247-4.
- Yang J., Zhou J., Wang X., Ji L., Wang S., Chen X., Yang L. Erythropoietin attenuates experimental contrast-induced nephrology: a role for the janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. Front Med (Lausanne). 2021;13(8):634882. doi: 10.3389/fmed.2021.634882.
- Kostina D.A., Pokrovskaya T.G., Poltev V.Y. Renoprotective effect of carbamylated darbepoetin and udenafi in ischemia-reperfusion of rat kidney due to the effect of preconditioning and inhibition of nuclear factor kappa B. Research Results in Pharmacology. 2021;7(1):1–20. doi: 10.3897/rrpharmacology.7.63059.
- Lokteva T.I., Rozhkov I.S., Gureev V.V., Gureeva A.V., Zatolokina M.A., Avdeyeva E.V., Zhilinkova L.A., Prohoda E.E., Yarceva E.O. Correction of morphofunctional disorders of the cardiovascular system with asialized erythropoietin and arginase II selective inhibitors KUD 974 and KUD 259 in experimental preeclampsia. Research Results in Pharmacology. 2020;6(1):29–40. doi: 10.3897/rrpharmacology.6.50851.
- Korokin M.V., Soldatov V.O., Tietze A.A. et al. 11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats. Farmatsiya i farmakologiya = Pharmacy & Pharmacology. 2019;7(6):312–320. (In Russ.). doi: 10.19163/2307-9266-2019-7-6-312-320.
- Peng B., Kong G., Yang C., Ming Y. Erythropoietin and its derivatives: from tissue protection to immune regulation. Cell Death Dis. 2020;11(2):79. doi: 10.1038/s41419-020-2276-8.
- Hukriede N.A., Soranno D.E., Sander V., Perreau T., Starr M.C., Yuen P.S.T., Siskind L.J., Hutchens M.P., Davidson A.J., Burmeister D.M., Faubel S., de Caestecker M.P. Experimental models of acute kidney injury for translational research. Nat Rev Nephrol. 2022;18(5):277–293. doi: 10.1038/s41581-022-00539-2.
- Nyman, U., Leander, P., Liss, P. et al. Absolute and relative GFR and contrast medium dose/GFR ratio: cornerstones when predicting the risk of acute kidney injury. Eur Radiol. 2023;10.1007/s00330-023-09962-w. doi: 10.1007/s00330-023-09962-w
- Dennen P., Altmann C., Kaufman J., Klein C.L., Andres-Hernando A., Ahuja N.H., Edelstein C.L., Cadnapaphornchai M.A., Keniston A., Faubel S. Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Crit Care. 2010;14(5):R181. doi: 10.1186/cc9289.
