Use of the antioxidant complex Androdoz in infertile men

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Introduction. Infertility is a global problem, affecting more than 15% of sexually active couples worldwide. The frequency of the male factor reaches 40–50% and continues to increase. Fertility problems with unknown causes are referred as idiopathic.

Aim. To evaluate the possibility of using the Androdoz antioxidant complex in men with infertility.

Materials and methods. A retrospective analysis of the medical records of 32 infertile men aged 21 to 45 years (average of 27.8 ± 6.7 years) with pathospermia was carried out. Antioxidant complex Androdoz was prescribed 2 capsules bid with meals according to the package insert for up to 3 months. The results were assessed after 3 and 12 months (follow-up period) from the start of therapy. In addition to ejaculate analysis, all patients underwent digital rectal examination, transrectal ultrasound of the prostate and ultrasound of the scrotum, microscopic examination of ejaculate and expressed prostate secretions, and PCR-based assay of urethral swab (Androflor). The zinc concentration in seminal plasma, as well as the total antioxidant capacity of sperm, was also evaluated. Damage to sperm chromosomes was characterized by DNA fragmentation using an assessment of sperm chromatin dispersion.

Results. Based on the results of a comparative analysis of ejaculate, it was revealed that taking Androdoz complex not only had a positive effect on sperm motility and viability, but also led to a decrease in the percentage of sperm with DNA fragmentation to a level of less than 15%, and significantly increased the total antioxidant capacity of the ejaculate.

Conclusions. The use of Androdoz antioxidant complex in men with reproductive disorders improves the qualitative and quantitative markers of the sperm analysis and the morphological state of the male reproductive system, and allows to replenish the lack of vitamins. The most important effect of Androdoz complex appears after 3 months.

Full Text

Restricted Access

About the authors

N. A. Nashivochnikova

Privolzhsky Research Medical University of the Ministry of Health of the Russia

Author for correspondence.
Email: dom17.doctor@mail.ru
ORCID iD: 0000-0002-1138-1174

Ph.D., associate professor at the Department of Urology named after E.V. Shakhov

Russian Federation, Nizhny Novgorod

V. N. Krupin

Privolzhsky Research Medical University of the Ministry of Health of the Russia

Email: dom17.doctor@mail.ru
ORCID iD: 0000-0002-4887-4888

Ph.D., MD, professor, Head of the Department of Urology named after E.V. Shakhov

Russian Federation, Nizhny Novgorod

References

  1. Jo J., Lee S.H., Lee J.M., Jerng U.M. Semen quality improvement in a man with idiopathic infertility treated with traditional Korean medicine: a case report. Explore (NY) 2015; 11(4):320–323. doi: 10.1016/j.explore.2015.04.007. PMID: 26025007.
  2. Lindsay T.J., Vitrikas K.R. Evaluation and treatment of infertility. Am Fam Physician 2015;91(5):308–314. PMID: 25822387.
  3. Rusanova N.E. Assisted reproductive technologies in Russia: history, problems, demographic prospects. Journal of Social Policy Research 2013;11(1):69–86. Russian (Русанова Н.Е. Вспомогательные репродуктивные технологии в России: история, проблемы, демографические перспективы. Журнал исследований социальной политики. 2013;11(1):69–86).
  4. Aylamazyan E.K., Belyaeva T.V. Theory and practice of general ecological reproductology. Journal of Obstetrics and Women’s Diseases. 2000;3:8–10. Russian (Айламазян Э.К., Беляева Т.В. Теория и практика общей экологической репродуктологии. Журнал акушерства и женских болезней. 2000;3:8–10).
  5. WHO laboratory manual for the examination and processing of human semen. 5th edn. Geneva, 2010. 287 p. Available at: http://apps.who.int/ iris/bitstream/10665/44261/1/ 9789241547789_eng.pdf.
  6. Bozhedomov V.A., Nikolaeva M.A., Ushakova I.V. and others. The role of free radical oxidation processes in the pathogenesis of male immune infertility. Andrology and genital surgery. 2010;11(4):62–66. Russian (Божедомов В.А., Николаева М.А., Ушакова И.В. и др. Роль процессов свободно-радикального окисления в патогенезе мужского иммунного бесплодия. Андрология и генитальная хирургия. 2010;11(4):62–66).
  7. Alexandrov O.A., Kogan V.L., Korotkiy R.V. and others. Health protection at the present stage of scientific and technological progress. M., 1987. 150 p. Russian (Александров О.А., Коган В.Л., Короткий Р.В. и др. Охрана здоровья на современном этапе научно-технического прогресса. М., 1987. 150 с.).
  8. Hamada A., Esteves S.C., Nizza M., Agarwal A. Unexplained male infertility: diagnosis and management. Int Braz J Urol. 2012;38(5):576–594. PMID: 23131516.
  9. Ramasamy R., Stahl P.J., Schlegel P.N. Medical therapy for spermatogenic failure. Asian J Androl 2012;14(1):57–60. doi: 10.1038/aja.2011.63. PMID: 22179517.
  10. Bozhedomov V.A., Nikolaeva M.A., Ushakova I.V., Bozhedomova G.E., Lipatova N.A., Kamarina R.A., Okhobotov D.A., Kamalov A.A. The structure of sperm quality disorders in men from infertile couples and the algorithm for managing such patients in specialized institutions of the third level. Obstetrics and gynecology. 2020;11:159–167. doi: 10.18565/aig.2020.11.159-167. Russian (Божедомов В.А., Николаева М.А., Ушакова И.В., Божедомова Г.Е., Липатова Н.А., Камарина Р.А., Охоботов Д.А., Камалов А.А. Структура нарушений качества спермы у мужчин из бесплодных пар и алгоритм ведения таких пациентов в специализированных учреждениях третьего уровня. Акушерство и гинекология. 2020;11:159–167. doi: 10.18565/aig.2020.11.159-167).
  11. Agarwal A., Sharma R.K., Nallella K.P. et al. Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril. 2006;86(4):878–885. doi: 10.1016/j.fertnstert.2006.02.111.
  12. Aitken R.J., Clarkson J.S., Fishel S. Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod. 1989;41(1):183–197.
  13. Beinert T., Binder D., Stuschke M. et al. Oxidant-induced lung injury in anticancer therapy. Eur J Med Res 1999;4(2):43–53. PMID: 10066639.
  14. Vorobyova O.A., Voskresenskaya A.V., Odintsovo A.A., Filatov M.V. Male infertility and violation of the structural organization of sperm chromatin. Is there a connection? Reproduction problems. 2005;11(6):56–62. Russian (Воробьева О.А., Воскресенская А.В., Одинцов А.А., Фила- тов М.В. Мужское бесплодие и нарушение структурной организации хроматина сперматозоидов. Существует ли связь? Проблемы репродукции. 2005;11(6):56–62).
  15. Agarwal A., Saleh R.A., Bedaiwy M.A. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2003;79(4):829–843.
  16. Bozhedomov V.A., Lipatova N.A., Bozhedomova G.E., Shcherbakova E.V., Komarina R.A. The use of a nutrient complex for the treatment of male infertility. RMZH. 2016;23:1546–1552. Russian (Божедомов В.А., Липатова Н.А., Божедомова Г.Е., Щербакова Е.В., Комарина Р.А. Применение комплекса нутриентов для лечения мужского бесплодия. РМЖ. 2016;23:1546–1552).
  17. Micic S., Lalic N., Djordjevic D., Bojanic N., Bogavac-Stanojevic N., Busetto G.M., Virmani A., Agarwal A. Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia. Andrologia. 2019;51(6):e13267. doi: 10.1111/and.13267.
  18. Haseen Ahmed S.D., Ahsan S., Iqbal T., Ahmed urney S.I. Relationship of seminal free L-carnitine with functional spermatozoal characteristics: Results from an observational study conducted in a tertiary care hospital of Karachi, Pakistan. Journal of Pakistan Medical Association. 2017;67(2):280–284. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28138186
  19. Bozhedomov V.A., Lipatova N.A., Bozhedomova G.E., Rokhlikov I.M., Shcherbakova E.V., Kamarina R.A. The use of L- and acetyl-L-carnitines in combination with clomiphene citrate and an antioxidant complex for the treatment of idiopathic male infertility: a prospective randomized study. Urologiia. 2017;(3):22–32. Russian (Божедомов В.А., Липатова Н.А., Божедомова Г.Е., Рохликов И.М., Щербакова Е.В., Камарина Р.А. Применение L- и ацетил-L-карнитинов в комбинации с кломифеном цитратом и комплексом антиоксидантов для лечения идиопатического мужского бесплодия: проспективное рандомизированное исследование. Урология. 2017;(3):22–32).
  20. Zhukov O.B., Bragina E.E., Levina A.V. et al. Comparison of the effectiveness of drugs containing a combination of arginine and zinc in the treatment of male infertility. Andrology and genital surgery. 2020;21(2):26–35. Russian (Жуков О.Б., Брагина Е.Е., Левина А.В. и др. Сравнение эффективности препаратов, содержащих комбинацию аргинина и цинка, в лечении мужского бесплодия. Андрология и генитальная хирургия. 2020;21(2):26–35).
  21. Chen J.Q., Li Y.S., Li Z.J., Lu H.X., Zhu P.Q., Li C.M. Dietary L-arginine supplementation improves semen quality and libido of boars under high ambient temperature. Animal. 2018;12(8):1611–1620. doi: 10.1017/S1751731117003147.
  22. Li Y., Chen J., Li Z., Li C. Mitochondrial OXPHOS is involved in the protective effects of L-arginine against heat-induced low sperm motility of boar. J Therm Biol. 2019;84:236–244. doi: 10.1016/j.jtherbio.2019.07.008.
  23. Kulakova S.N., Baturina V.A., Sharanova N.E. and others. The effect of coenzyme KoQ10 on apoptosis, free radical oxidation processes, and the proteomic pool of microsomal and cytosolic fractions of hepatocytes when consuming diets with a different fat component. Nutrition issues. 2012;81(5):51‒59. Russian (Кулакова С.Н., Батурина В.А., Шаранова Н.Э. и др. Влияние коэнзима KoQ10 на апоптоз, процессы свободнорадикального окисления, протеомный пул микросомальной и цитозольной фракций гепатоцитов при потреблении рационов с различным жировым компонентом. Вопросы питания. 2012;81(5):51‒59).
  24. Mancini A., Balercia G. Coenzyme Q (10) in male infertility: physiopathology and therapy. Biofactors. 2011;37(5):374‒380.
  25. Nadjarzadeh A., Sadeghi M., Amirjannati N. et al. Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. J. Endocrinol. Invest. 2011;34(8):224‒228.
  26. Safarinejad M., Safarinejad S., Shafiei N. Effects of the reduced form of coenzyme Q(10) (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. J. Urol. 2012;188(2):526–531.
  27. Mohammad K. Moslemi, Samaneh Tavanbakhsh. Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med. 2011;4:99–104. doi: 10.2147/IJGM.S16275.
  28. Momeni H.R., Eskandari N. Effect of vitamin E on sperm parameters and DNA integrity in sodium arsenite-treated rats. Iran. J. Reprod. Med. 2012;10(3):249–256.
  29. Zu K., Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res. 2003;63(20):6988–6995.
  30. Borisov V.V. Male infertility. The use of zinc and antioxidants in the treatment of fertility disorders and inflammatory diseases of the male genitals (clinical lecture). Consilium Medicum. 2015;17(7):16–23. Russian (Борисов В.В. Мужское бесплодие. Применение цинка и антиоксидантов в терапии нарушений фертильности и воспалительных заболеваний мужских гениталий (клиническая лекция). Consilium Medicum. 2015;17(7): 16–23).
  31. Mukhina Yu.G., Klyuchnikov S.O., Netrebenko O.K., Shcheplyagina L.A. The clinical significance of zinc metabolism disorders. 2011. Russian (Мухина Ю.Г., Ключников С.О., Нетребенко О.К., Щеплягина Л.А. Клиническое значение нарушений метаболизма цинка. 2011).
  32. Osadchuk L.V., Danilenko A.D., Osadchuk A.V. The effect of zinc on male infertility. Urologiia. 2021;5:84–93. Russian (Осадчук Л.В., Данилен- ко А.Д., Осадчук А.В. Влияние цинка на мужское бесплодие. Урология. 2021;5:84–93).
  33. Gamidov S.I., Viryasov A.V., Shcherbakov D.V., Tkhagapsoeva R.A. The role of trace elements in the treatment of male infertility. Clinical bulletin «Kremlin medicine». 2009;2:22–25. Russian (Гамидов С.И., Вирясов А.В., Щербаков Д.В., Тхагапсоева Р.А. Роль микроэлементов в лечении мужского бесплодия. Клинический вестник «Кремлевская медицина». 2009;2:22–25).
  34. Bratchikov O.I., Dubonos P.A., Tyuzikov I.A. Features of zinc metabolism and its relationship with the oxidative status of the prostate gland in healthy men and patients with chronic bacterial prostatitis. Effective pharmacotherapy. 2021;17(17):6–14. Russian (Братчиков О.И., Дубонос П.А., Тюзиков И.А. Особенности обмена цинка и его связь с оксидативным статусом предстательной железы у здоровых мужчин и больных хроническим бактериальным простатитом. Эффективная фармакотерапия. 2021;17(17):6–14).
  35. Kashou A., Sharma R., Agarwal A. Assessment of oxidative stress in sperm and semen. Methods Mol Biol. 2013; 927:351–361.
  36. Gassei K., Orwig K.E. Experimental methods to preserve male fertility and treat male factor infertility. Fertil Steril. 2016;105(2):256–266.
  37. Bozhedomov V.A. Andrology. Pharmacotherapy without errors. A guide for doctors / ed. Kamalova A.A. M.: E-noto, 2017. pp. 202–232. Russian (Божедомов В.А. Андрология. Фармакотерапия без ошибок. Руководство для врачей / под ред. Камалова А.А. М.: Е-ното, 2017. С. 202–232).
  38. Salonia A. (Chair), Bettocchi C., Carvalho J., Corona G., Jones T.H., Kadioglu A., Martinez-Salamanca J.I., Minhas S. (Vice-chair), Serefoglu E.C., Verze P. European Association of Urology Guidelines on Sexual and Reproductive Health 2020.
  39. Showell M.G., Mackenzie-Proctor R., Brown J. et al. Antioxidants for male subfertility. Cochran Database Syst. Rev 2014. Vol. 12. CD007411.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies