Regnerative technologies in reconstructive operations on the urethra: a review. Part 2

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Abstract

Recent advances in the treatment of urethral strictures are associated with regenerative medicine and tissue engineering. Urethral reconstruction in some cases is a difficult task for urologists due to the insufficient amount of autologous tissue and relapses, which encourages clinicians to search for alternatives. The purpose of this work is to review the latest achievements in the use of regenerative technologies, biomaterials and cell therapy in urethroplasty. The second part of the literature review presents the prospects of using the stromal vascular fraction (SVF) of autologous adipose tissue during reconstructive operations on the urethra, especially considering the availability of these cells through lipoaspiration. Tissue engineering technologies are reflected, which offer their own solutions to problems and limitations of their use. The article also provides examples of experimental studies in which cell-free and cellular biomaterials were used for urethral reconstruction.

We believe that the approach of using SVF and biomatrix can become a potentially safe and effective method of therapy associated with the acceleration of regeneration processes, and can be of great benefit to patients with urethral diseases in the future.

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About the authors

V. N. Pavlov

Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation

Email: pavlov@bashgmu.ru

Rector, Academician of the Russian Academy of Medical Sciences, MD, Professor, Head of the Department of Urology with the course Institute of Additional Professional Education

Russian Federation, Ufa

R. А. Kazikhinurov

Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation

Email: royuro@mail.ru

Cand. Sci. (Med.), Associate Professor of the Department of Urology with the course Institute of Additional Professional Education

Russian Federation, Ufa

А. А. Kazikhinurov

Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation

Email: alberturo@mail.ru

MD, Professor of the Department of Urology with the course of the Institute of Additional Professional Education

Russian Federation, Ufa

R. I. Guspanov

Federal State Budgetary Educational Institution of Higher Education N. I. Pirogov Russian National Research Medical University

Email: doctorren@mail.ru

Cand. Sci. (Med.), Associate Professor of the Department of

Urology and Andrology of the Medical Faculty

Russian Federation, Moscow

B. I. Shamsov

Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation

Email: bedilshamsov@mail.ru

postgraduate student of the Department of Urology with the course Institute of Additional Professional Education

Russian Federation, Ufa

А. G. Vardikian

Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation

Email: a@urologufa.ru

postgraduate student of the Department of Urology with the course Institute of Additional Professional Education

Russian Federation, Ufa

R. R. Kazikhinurov

Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: raduro@mail.ru

Resident of the Department of Oncology with the course of Oncology and pathological anatomy

Russian Federation, Ufa

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