The use of a urethral catheter with an ultrasound-induced biopolymer drug coating for the prevention of recurrent bladder neck sclerosis in patients after endoscopic treatment of benign prostate hyperplasia

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Recurrent bladder neck sclerosis is one of the common complications of endoscopic treatment of benign prostate hyperplasia, which often leads to multiple re-operations, including complex open and laparoscopic reconstructive procedures. One of the most promising minimally invasive methods for preventing recurrence of bladder neck sclerosis is balloon dilatation under transrectal ultrasound guidance. To improve the results of using this technique, a urethral catheter with a biopolymer coating, capable of depositing a drug and eluting it under the influence of diagnostic ultrasound, was proposed.

Full Text

Restricted Access

About the authors

А. А. Kamalov

Lomonosov Moscow State University; Lomonosov MSU Medical Research and Educational Center

Email: armais.kamalov@rambler.ru
ORCID iD: 0000-0003-4251-7545

Academician of the Russian Academy of Sciences, M.D., Dr.Sc.(M), Full Prof., Head, Dept. of Urology and Andrology, Faculty of Fundamental Medicine, Headmaster

Russian Federation, Moscow; Moscow

N. I. Sorokin

Lomonosov Moscow State University; Lomonosov MSU Medical Research and Educational Center

Email: nisorokin@mail.ru
ORCID iD: 0000-0001-9466-7567

M.D., Dr.Sc.(M), Full Prof., Head, Urological Service of the Medical Research and Education Center, Senior Researcher, Urology and Andrology Branch, Faculty of Fundamental Medicine

Russian Federation, Moscow; Moscow

А. V. Kadrev

Lomonosov MSU Medical Research and Educational Center

Email: akadrev@yandex.ru
ORCID iD: 0000-0002-6375-8164

M.D., Сand.Sc.(Med), Head, Ultra-sound Diagnostics Division, Researcher, Urology and Andrology Unit

Russian Federation, Moscow

B. М. Shaparov

Lomonosov Moscow State University; Moscow City Clinical Hospital No. 17

Email: trafford09@mail.ru
ORCID iD: 0000-0002-0232-1567

M.D., Cand.Sc.(M), Urologist, Urology Division

Russian Federation, Moscow; Moscow

Е. V. Afanasevskaya

Lomonosov Moscow State University; Lomonosov MSU Medical Research and Educational Center; Istra Regional Clinical Hospital

Email: e.afanasyevskaya@mail.ru
ORCID iD: 0000-0002-0161-6072

M.D., Urologist, Urology Division, Postgrad. Student, Dept. of Urology and Andrology, Faculty of Fundamental Medicine, Urologist

Russian Federation, Moscow; Moscow; Istra

О. А. Sindeeva

A.V. Zelmann Center for Neurobiology and Brain Rehabilitation Skolkovo Institute of Science and Technology

Email: o.sindeeva@skoltech.ru
ORCID iD: 0000-0002-5288-4157

Ph.D. in biology, researcher

Russian Federation, Moscow

G. B. Sukhorukov

A.V. Zelmann Center for Neurobiology and Brain Rehabilitation Skolkovo Institute of Science and Technology

Email: g.sukhorukov@skoltech.ru
ORCID iD: 0000-0001-6213-0562

Ph.D. in physical and mathematical sciences, professor

Russian Federation, Moscow

А. А. Kritsky

LLC Magnetic Drug Delivery AMT & C Group

Email: kritskiy@amtc.org
ORCID iD: 0000-0001-8087-0302

Executive Director

Russian Federation, Moscow

N. А. Pyataev

Institute of Medicine, National Research Ogarev Mordovia State University

Email: pyataevna@mail.ru
ORCID iD: 0000-0002-9688-7640

Ph.D., MD, Head of the Department of Anesthesiology and Reanimatology, Transfusiology with a course in Disaster Medicine, Institute of Medicine

Russian Federation, Saransk

А. S. Abdurashitov

A.V. Zelmann Center for Neurobiology and Brain Rehabilitation Skolkovo Institute of Science and Technology

Author for correspondence.
Email: a.abdurashitov@skoltech.ru
ORCID iD: 0000-0003-0731-8364

Ph.D. in physical and mathematical sciences, researcher

Russian Federation, Moscow

О. А. Kulikov

Institute of Medicine, National Research Ogarev Mordovia State University

Email: oleg-kulikov-84@mail.ru
ORCID iD: 0000-0003-0117-3563

Ph.D., MD, professor at the Department of Pharmacology and Clinical Pharmacology with a course of the Pharmaceutical Technology, Institute of Medicine

Russian Federation, Saransk

P. I. Proshin

Institute of Medicine, National Research Ogarev Mordovia State University

Email: pavel.proshin@skoltech.ru
ORCID iD: 0000-0002-6056-3265

Ph.D. student A.V. Zelmann Center for Neurobiology and Brain Rehabilitation

Russian Federation, Saransk

References

  1. Lopatkin N.A. National guide to urology. GEOTAR-Med. M., 2013. pp. 566–568. Russian (Лопаткин Н.А. Национальная руководство по урологии. ГЭОТАР-Мед. М., 2013. с. 566–568).
  2. Denslow F.M. Recurrence of urinary obstruction after prostatectomy. The Journal of the American Medical Association. 1918;70(7):441.
  3. Leyh H., Necknig U. Transurethrale Prostatektomie. Komplikations management. Urologe A. 2014;53(5):699–705.
  4. Parihar J.S., Ha Y.S., Kim I.Y. Bladder neck contracture – incidence and management following contemporary robot assisted radical prostatectomy technique. Prostate Int. 2014;2(1):12–18.
  5. Cindolo L., Marchioni M., Emiliani E., De Francesco P., Primiceri G., Castellan P., Schips L. Bladder neck contracture after benign prostatic obstruction. Minerva Urol Nefrol. 2017;69(2):133–143.
  6. Puppo P., Bertolotto F., Introini C., Germinale F., Timossi L., Naselli A. Bipolar transurethral resection in saline (TURis): outcome and complication rates after the first 1000 cases. J Endourol. 2009;23(7):1145–1149.
  7. EAU Guidelines. Edn. presented at the EAU Annual Congress Milan March 2023. ISBN 978-94-92671-19-6
  8. Chen Y.Z., Lin W.R., Chow Y.C., Tsai W.K., Chen M., Chiu A.W. Analysis of risk factors of bladder neck contracture following transurethral surgery of prostate. BMC Urol. 2021;21(1):59. doi: 10.1186/s12894-021-00831-6
  9. Primiceri G., Castellan P., Marchioni M., Schips L., Cindolo L. Bladder Neck Contracture After Endoscopic Surgery for Benign Prostatic Obstruction: Incidence, Treatment, and Outcomes. Curr Urol Rep. 2017;18(10):79. doi: 10.1007/s11934-017-0723-6.
  10. Spahn M., Kocot A., Loeser A., Kneitz B., Riedmiller H. Last resort in devastated bladder outlet: bladder neck closure and continent vesicostomy – long-term results and comparison of different techniques. Urology. 2010;75:1185–1192.
  11. Popov S.V., Orlov I.N., Tsoi A.V., Topuzov T.M., Chernysheva D.Yu. YV-plasty in the treatment of patients with recurrent bladder neck stenosis. Bulletin of Urology. 2022;10(1):52–59. https://doi.org/10.21886/2308-6424-2022-10-1-52-59. Russian (Попов С.В., Орлов И.Н., Цой А.В., Топузов Т.М., Чернышева Д.Ю. YV-пластика при лечении пациентов с рецидивирующим стенозом шейки мочевого пузыря. Вестник урологии. 2022;10(1):52-59. https://doi.org/10.21886/2308-6424-2022-10-1-52-59).
  12. Redshaw J.D., Broghammer J.A., Smith T.G., Voelzke B.B., Erickson B.A., McClung C.D., Elliot S.P., Alsikafi N.F., Presson A.P., Aberger M.E., Craig J.R., Brant W.O., Myers J.B. Intralesional injection of mitomycin C at transurethral incision of bladder neck contracture may offer limited benefit: TURNS study group. J Urol. 2015;193(2):587–592.
  13. Zhang L., Liu Sh., Wu K., Mu X., Yang L. Management of highly recurrent bladder neck contractures via transurethral resection combined with intra- and post-operative triamcinolone acetonide injections. World Journal of Urology. 2021;39(2):527–532.
  14. Kudryavtsev Yu.V., Kirpatovsky V.I., Perepanova T.S., Khazan P.L. The use of a stabilizer of glycosaminoglycans – zinc hyaluronate in experimental modeling of acute bacterial and interstitial cystitis. Experimental and clinical urology. 2011;1:39–44. Russian (Кудрявцев Ю.В., Кирпатовский В.И., Перепанова Т.С., Хазан П.Л. Применение стабилизатора гликозаминогликанов – гиалуроната цинка при экспериментальном моделировании острого бактериального и интерстициального цистита. Экспериментальная и клиническая урология. 2011;1:39–44).
  15. Patent No. 2725549 C1 Russian Federation, IPC A61B 17/225; A61M 25/00. A method for the prevention of scarring of the neck of the bladder after endoscopic removal of prostate hyperplasia: No. 2019143157: application 23.12.2019: publ. 02.07.2020/A.A. Kamalov, N.I. Sorokin, A.V. Karev, V.K. Dzitiev, D.M. Kamalov, B.M. Kaparov, A.S. Tivtikyan, S.A. Abbasov, A.M. Pshikhachev; the applicant A.A. Kamalov. Russian (Патент № 2725549 С1 Российская Федерация, МПК A61B 17/225; A61M 25/00. Способ профилактики рубцовой деформации шейки мочевого пузыря после эндоскопического удаления гиперплазии простаты: № 2019143157: заявл. 23.12.2019: опубл. 02.07.2020 / А.А. Камалов, Н.И. Сорокин, А.В. Кадрев, В.К. Дзитиев, Д.М. Камалов, Б.М. Шапаров, А.С. Тивтикян, Ш.А. Аббосов, А.М. Пшихачев; заявитель А.А. Камалов).
  16. Abbosov Sh.A., Okhobotov D.A., Sorokin N.I., Shomarufov A.B., Shaparov B.M., Najimitdinov Ya.S., Mukhtarov Sh.T., Akilov F.A., Kamalov A.A. Evaluation of the effectiveness of balloon dilation of cicatricial narrowing of the bladder neck after transurethral interventions on the prostate gland (preliminary results). Bulletin of Urology. 2021;9(1):5–12. Russian (Аббосов Ш.А., Охоботов Д.А., Сорокин Н.И., Шомаруфов А.Б., Шапаров Б.М., Наджимитдинов Я.С., Мухтаров Ш.Т., Акилов Ф.А., Камалов А.А. Оценка эффективности баллонной дилатации рубцового сужения шейки мочевого пузыря после трансуретральных вмешательств на предстательной железе (предварительные результаты). Вестник урологии. 2021;9(1):5–12).
  17. Abbosov Sh.A., Sorokin N.I., Shomarufov A.B., Kadrev A.V., Mikheev K.V., Fozilov A.A., Nadjimitdinov Y.S., Ohobotov D.A., Mukhtarov Sh.T., Akilov F.A., Kamalov A.A. Assessment of balloon dilation efficiency in bladder neck contracture after transurethral interventions on the prostate. Urological Science. 2022;34(3):130–135.
  18. Sindeeva O.A., Abdurashitov A.S., Proshin P.I., Kadrev A.V., Kulikov O.A., Shaparov B.M., Sorokin N.I., Ageev V.P., Pyataev N.A., Kritskiy A., Tishin A., Kamalov A.A., Sukhorukov G.B. Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation. Pharmaceutics. 20223;14(10):2186. doi: 10.3390/pharmaceutics14102186.
  19. Kopach O., Zheng K., Sindeeva O.A., Gai M., Sukhorukov G.B., Rusakov D.A. Polymer microchamber arrays for geometry-controlled drug release: a functional study in human cells of neuronal phenotype. Biomater Sci. 2019;7(6):2358–2371. doi: 10.1039/c8bm01499j.
  20. Sindeeva O.A., Kopach O., Kurochkin M.A., Sapelkin A., Gould D.J., Rusakov D.A., Sukhorukov G.B. Polylactic Acid-Based Patterned Matrixes for Site-Specific Delivery of Neuropeptides On-Demand: Functional NGF Effects on Human Neuronal Cells. Front Bioeng Biotechnol. 2020;8:497. doi: 10.3389/fbioe.2020.00497.
  21. Gai M., Kurochkin M.A., Li D., Khlebtsov B.N., Dong L., Tarakina N., Poston R., Gould D.J., Frueh J., Sukhorukov G.B. In-situ NIR-laser mediated bioactive substance delivery to single cell for EGFP expression based on biocompatible microchamber-arrays. J Control Release. 2018;276:84–92. doi: 10.1016/j.jconrel.2018.02.044.
  22. Mordovina E.A., Plastun V.O., Abdurashitov A.S., Proshin P.I., Raikova S.V., Bratashov D.N., Inozemtseva O.A., Goryacheva I.Y., Sukhorukov G.B., Sindeeva O.A. «Smart» Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays for Personalized Antibiotic Therapy. Pharmaceutics. 2021;14(1):42. doi: 10.3390/pharmaceutics14010042.
  23. Gai M., Frueh J., Tao T., Petrov A.V., Petrov V.V., Shesterikov E.V., Tverdokhlebov SI, Sukhorukov GB. Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound. Nanoscale. 2017;9(21):7063-7070. doi: 10.1039/c7nr01841j.
  24. Sindeeva O.A., Prikhozhdenko E.S., Schurov I., Sedykh N., Goriainov S., Karamyan A., Mordovina E.A., Inozemtseva O.A., Kudryavtseva V., Shchesnyak L.E., Abramovich R.A., Mikhajlov S., Sukhorukov G.B. Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies. Pharmaceutics. 2021;13(9):1437. doi: 10.3390/pharmaceutics13091437.
  25. Sindeeva O.A., Gusliakova O.I., Inozemtseva O.A., Abdurashitov A.S., Brodovskaya E.P., Gai M., Tuchin V.V., Gorin D.A., Sukhorukov G.B. Effect of a Controlled Release of Epinephrine Hydrochloride from PLGA Microchamber Array: In Vivo Studies. ACS Appl Mater Interfaces. 2018;10(44):37855-37864. doi: 10.1021/acsami.8b15109.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1.

Download (2MB)
Indexing metadata
3. Fig. 2.

Download (2MB)
Indexing metadata
4. Fig. 3.

Download (1MB)
Indexing metadata

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies