The use of antioxidants in combination therapy of chronic prostatitis

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Abstract

Currently, the significance of the chronic prostatitis (CP) is undoubted. Oxidative stress is considered as one of the standard mechanisms of cellular damage that is associated with inflammatory diseases such as CP. When choosing the combination therapy for this group of patients, a correction of oxidative stress is pathogenetically justified.

Literature data about the pathogenetic feasibility and prospects of using a biologically active complex containing flavonoids and carotenoids quercetin, lycopene and naringin as part of the combination treatment of patients with CP are presented in the article.

Considering the various effects of the biologically active complex Querceprost®, containing quercetin, lycopene and naringin, among which antioxidant, anti-inflammatory, antimicrobial and immunomodulatory are of greatest importance, as well as taking into account the synergistic effect of flavonoids and carotenoids, we suggest that Querceprost® is promising component of combination treatment of patients with CP.

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About the authors

A. V. Kuzmenko

FGBOU VO «Voronezh State Medical University named after N.N. Burdenko»

Author for correspondence.
Email: kuzmenkoav09@yandex.ru
ORCID iD: 0000-0002-7927-7015

Ph.D., MD, professor, professor at the Department of Specialized Surgical disciplines of FGBOU VO «Voronezh State Medical University named after N.N. Burdenko»

Russian Federation, Voronezh

T. A. Gyaurgiev

FGBOU VO «Voronezh State Medical University named after N.N. Burdenko»

Email: gta001100@yandex.ru
ORCID iD: 0000-0002-2209-6264

Ph.D., associate professor at the Department of Specialized Surgical disciplines of FGBOU VO «Voronezh State Medical University named after N.N. Burdenko»

Russian Federation, Voronezh

V. V. Kuzmenko

FGBOU VO «Voronezh State Medical University named after N.N. Burdenko»

Email: kuzmenkovv2003@mail.ru
ORCID iD: 0000-0001-7803-8832

Ph.D., MD, professor, professor at the Department of Specialized Surgical disciplines of FGBOU VO «Voronezh State Medical University named after N.N. Burdenko»

Russian Federation, Voronezh

G. A. Kuzmenko

FGBOU VO «Voronezh State Medical University named after N.N. Burdenko»

Email: KGA00110009@yandex.ru

3-year student of the Pediatric faculty of FGBOU VO «Voronezh State Medical University named after N.N. Burdenko»

Russian Federation, Voronezh

References

  1. Urology. Russian clinical guidelines. Under the editorship of Yu.G. Alyaev, P.V. Glybochko, D. u. Pushkar. M.: GEOTAR-Media; 2018. 480 s. Russian (Урология. Российские клинические рекомендации. Под ред. Ю.Г. Аляева, П.В. Глыбочко, Д.Ю. Пушкаря. М.: ГЭОТАР-Медиа; 2018. 480 с.).
  2. Engeler D., Messelink E.J., Baranowski A.P. et al. EAU guidelines on chronic pelvic pain. 2022. ISBN 978-94-92671-07-3. Available at: https://uroweb.org/guidelines/chronic-pelvic-pain
  3. Nickel J. Prostatitis. CUA Guidelines. Canadian Urol. Assoc. J. 2011;5(5):306–315. https://www.ncbi.nlm.nih.gov/ pubmed/22031609
  4. Schaeffer A.J. Classification (Traditional and National Institutes of Health) and Demographics of Prostatitisю Urology. 200;60(6 Suppl):5-6; discussion 6-7. doi: 10.1016/s0090-4295(02)02292-6.
  5. Krieger J.N., Nyberg L. Jr, Nickel J.C. NIH consensus definition and classification of prostatitis. JAMA. 1999;282(3):236–237.
  6. Pushkar D.Yu., Segal A.S. Chronic abacterial prostatitis: a modern understanding of the problem. Vrachebnoe soslovie=Medical Caste 2004;(5-6):9–11. Russian (Пушкарь Д.Ю., Сегал А.С. Хронический абактериальный простатит: современное понимание проблемы. Врачебное сословие 2004;(5-6):9–11).
  7. Tyuzikov I.A., Grekov E.A. Chronic prostatitis/chronic pelvic pain syndrome: current trends and treatment prospects from the standpoint of evidence-based medicine. Experimental and Clinical Urology 2022;15(1):90–100. doi: 10.29188/2222-8543-2022-15-1-90-100 Russian (Тюзиков И.А., Греков Е.А. Хронический простатит/синдром хронической тазовой боли: современные тренды и перспективы лечения с позиций доказательной медицины. Экспериментальная и клиническая урология 2022;15(1):90–100 doi: 10.29188/2222-8543-2022-15-1-90-100)
  8. Bratchikov O.I., Dubonos P.A., Tyuzikov I.A., Shumakova E.A. Mechanisms of oxidative stress in the pathogenesis of chronic bacterial prostatitis (literature review). Andrology and Genital Surgery. 2022;23(3):19–28. doi: 10.17650/2070-9781-2022-23-3-19-28 Russian (Братчиков О.И., Дубонос П.А., Тюзиков И.А., Шумакова Е.А. Механизмы окислительного стресса в патогенезе хронического бактериального простатита (обзор литературы). Андрология и генитальная хирургия. 2022;23(3):19–28. doi: 10.17650/2070-9781-2022-23-3-19-28).
  9. Gorbachev A.G., Borovets S.Yu., Al-Shukri S.H. et al. Chronic prostatitis: infectious or noninfectious? (clinical experimental research). Meditsina i obrazovanie v Sibiri = Journal of Siberian Medical Sciences 2013;(5):7–10. Russian (Горбачев А.Г., Боровец С.Ю., Аль-Шукри С.Х. и др. Хронический простатит: инфекционный или неинфекционный (клинико-экспериментальное исследование). Медицина и образование в Сибири 2013;(5):7–10).
  10. Khan F.U., Ihsan A.U., Khan H.U. et al. Comprehensive overview of prostatitis. Biomed Pharmacother 2017;94:1064–1076. doi: 10.1016/j.biopha.2017.08.016.
  11. Novotny J., Oborna I., Brezinova J. et al. The occurrence of reactive oxygen species in the semen of males from infertile couples. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub. 2003;147(2):173–176.
  12. Popova A.Yu., Gamidov S.I., Ovchinnikov R.I. Use of antioxidants in a combination therapy of male infertility during inflammatory diseases. Effective pharmacotherapy. Urology and Nephrology. 2015;4(35):34–38.
  13. Agarwal A., Nallela K.P., Allamaneni S.S., Said T.M. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod. Biomed. Online. 2004;8(6):616–627.
  14. Zini A., De Lamirande E., Gagnon C. Low levels of nitric oxide promote human sperm capacitation in vitro. J. Androl. 1996;16(5):424–431.
  15. Kelley E.E., Paes A.M.A., Yadav H. et al. Interplay between oxidative stress and metabolism in signalling and disease 2016. Oxid Med Cell Longev. 2017;2017:70–72. doi: 10.1155/2017/7013972.
  16. Lugrin J., Rosenblatt-Velin N., Parapanov R., Liaudet L. The role of oxidative stress during inflammatory processes. Biol Chem. 2014;395(2):203–20. doi: 10.1515/hsz-2013-0241.
  17. Navarro-Yepes J., Burns M., Anandhan A. et al. Oxidative stress, redox signaling, and autophagy: cell death versus survival. Antioxid Redox Signal. 2014;21(1):66–85. doi: 10.1089/ars.2014.5837.
  18. Ihsan A.U., Khan F.U., Khongorzul P. et al. Role of oxidative stress in pathology of chronic prostatitis/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress. Biomed Pharmacother. 2018;106:714–723. doi: 10.1016/j.biopha.2018.06.139.
  19. Rees J., Abrahams M., Doble A., Cooper A. and the Prostatitis Expert Reference Group (PERG). Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome: a consensus guideline. BJU Int. 2015;116:509–525. 10.1111/bju.13101' target='_blank'>https://doi: 10.1111/bju.13101
  20. Kuzmenko A.V., Kuzmenko V.V., Gyaurgiev T.A. Combined drug therapy of patients with BPH. Urologiia. 2018;1:101–105. Russian (Кузьменко А.В., Кузьменко В.В., Гяургиев Т.А. Комбинированная медикаментозная терапия больных аденомой простаты. Урология. 2018;1:101–105).
  21. Gyaurgiev T.A., Kuzmenko A.V., Kuzmenko V.V. The efficiency of various cytokine therapy regimens in the complex treatment of men with chronic abacterial prostatitis. Urologiia. 2023;(1):12–19. Russian (Гяургиев Т.А., Кузьменко А.В., Кузьменко В.В. Эффективность различных схем цитокинотерапии в комплексном лечении мужчин с хроническим абактериальным простатитом. Урология. 2023;(1):12–19).
  22. Kuzmenko A.V., Kuzmenko V.V., Gyaurgiev T.A., Barannikov I.I. Chronobiological status of patients with chronic prostatitis on the background of prostate adenoma. System analysis and management in biomedical systems. 2017;16(3):513–316. Russian (Кузьменко А.В., Кузьменко В.В., Гяургиев Т.А., Баранников И.И. Хронобиологический статус больных хроническим простатитом на фоне аденомы предстательной железы. Системный анализ и управление в биомедицинских системах. 2017;16(3):513–316).
  23. Thakkinstian A., Attia J., Anothaisintawee T., Nickel J.C. α-blockers, antibiotics and anti-inflammatories have a role in the management of chronic prostatitis/chronic pelvic pain syndrome. BJU Int 2012;110(7):1014–1022.
  24. Bozhedomov V.A. Modern opportunities for the treatment of chronic prostatitis. Andrologiya i genital’naya khirurgiya=Andrology and Genital Surgery 2016;17(3):10–22. Russian (Божедомов В.А. Современные возможности лечения хронического простатита. Андрология и генитальная хирургия 2016;17(3):10–22).
  25. Kalghatgi S., Spina CS, Costello J.C. et al. Bactericidal antibiotics iduce mitihindrial dysfunction and oxidative damage in Mammalian cells. Sci Transi Med. 2013;5(192):85–89.
  26. Nickel J.C., Narayan P., MacKay J. et al. Treatment of chronic prostatitis/chronic pelvic pain syndrome with tamsulosin: a randomized double blind trial. Urology. 2004;171(4):1594–1597.
  27. Тkachenko Е.V. Application of Movalis suppositories in the urologist`s ambulance situation. Vrach= Physician 2010;(1):65–67. Russian (Ткачен-ко Е.В. Применение свечей мовалис в амбулаторной практике врача-уролога. Врач 2010;(1):65–67).
  28. Neymark А.I., Yakovets Ya.V., Аliev R.Т. Experience of Nise (Nimesulide) use in the comprehensive treatment of patients with chronic abacterial prostatitis with chronic pelvic pain syndrome. Urologiya=Urology 2004;(5):31–34. Russian (Неймарк А.И., Яковец Я.В., Алиев Р.Т. Опыт использования найза (нимесулид) в комплексном лечении больных хроническим абактериальным простатитом с синдромом хронической тазовой боли. Урология. 2004;(5):31–34).
  29. Rui-Min Han, Jian-Ping Zhang, Leif H. Reaction Dynamics of Flavonoids and Carotenoids as Antioxidants Molecules. 2012;17(2):2140–2160.
  30. Demmig-Adams B., Adams W.W., III. Antioxidants in photosynthesis and human nutrition. Science. 2002;298:2149–2153. doi: 10.1126/science.1078002.
  31. Pietta P.G. Flavonoids as Antioxidants. J. Nat. Prod. 2000;63:1035–1042. doi: 10.1021/np9904509.
  32. Paiva S.A., Russell R.M. β-Carotene and other carotenoids as antioxidants. J. Am. Coll. Nutr. 1999;18:426–433.
  33. Chiryapkin A.S., Zolotykh D.S., Pozdnyakov D.I. Review of the biological activity of flavonoids: quercetin and kaempferol. Juvenis scientia. 2023;9(2):5–20. doi: 10.32415/jscientia_2023_9_2_5-20. EDN: WING. Russian (Чиряпкин А.С., Золотых Д.С., Поздняков Д.И. Обзор биологической активности флавоноидов: кверцетина и кемпферола. Juvenis scientia. 2023;9(2):5–20. doi: 10.32415/jscientia_2023_9_2_5-20. EDN: WCLBZG).
  34. Xu D., Hu M.-J., Wang Y.-Q., et al. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Molecules. 2019;24(6):1123. doi: 10.3390/molecules24061123.
  35. Zhang M., Swartz S.G., Yin L., et al. Antioxidant Properties of Quercetin. Advances in Experimental Medicine and Biology. 2011;701:283–298. doi: 10.1007/978-1-4419-7756-4_3.
  36. Mlcek J., Jurikova T., Skrovankova S., et al. Quercetin and Its Anti-Allergic Immune Response. Molecules. 2016;21(5):623. doi: 10.3390/molecules21050623.
  37. Chirumbolo S. The Role of Quercetin, Flavonols and Flavones in Modulating Inflammatory Cell Function. Inflammation & Allergy. Drug Targets. 2010;9(4):263–285. doi: 10.2174/187152810793358741.
  38. Hung C.F., Huang T.F., Chen B.H. et al. Lycopene inhibits TNF‐alpha‐induced endothelial ICAM‐1 expression and monocyte‐endothelial adhesion. Eur J Pharmacol 2008;586:275–282.
  39. Napolitano M., De Pascale C., Wheeler-Jones C. et al.Effect of lycopene on the induction of foam cell formation by modified LDL. Am J Physiol Endocrinol Metab 2007;293:1820–1827.
  40. Ono M., Takeshima M., Nakano S. Mechanism of the anticancer effect of lycopene (tetraterpenoids). Enzymes. 2015;37:139–166.
  41. Bhuvaneswari V., Valmurugan B., Nagini S. Dose-response effect of tomato paste on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. J. Exp. Clin. Cancer Res. 2004;23:241–249.
  42. Ben-Dor A., Steiner M., Gheber L. et al. Carotenoids activate the antioxidant response element transcription system. Mol. Cancer Ther. 2005;4:177–186.
  43. Zhang B., Gu Y. Low expression of ERK signaling pathway affecting proliferation, cell cycle arrest and apoptosis of human gastric HGC-27 cells line. Mol. Biol. Rep. 2014;41:3659–3669.
  44. Velmurugan B., Mani A., Nagini S. Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis.Eur. J. Cancer Prev. 2005;14:387–393.
  45. Palozza P., Simone R., Catalano A. Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. J. Nutr. Biochem. 2011;22:259–268.
  46. Van Poppel H., Tombal B. Chemoprevention of prostate cancer with nutrients and supplements. Cancer Manag. Res.2011;3:91–100.
  47. Schwarz S., Obermüller-Jevic U.C., Hellmis E. et al. Lycopene inhibits disease progression in patients with benign prostate hyperplasia. J. Nutr. 2008;138:49–53.
  48. Ravetti S., Garro A.G., Gaitán A., Murature M., Galiano M., Brignone S.G., Palma S.D. Naringin. Encyclopedia. Available online: https://encyclopedia.pub/entry/42479 (accessed on 26 February 2024).
  49. Ghanbari-Movahed M., Jackson G., Farzaei M.H., Bishayee A. A systematic review of the preventive and therapeutic effects of naringin against human malignancies. Front. Pharmacol. 2021;12:639840.
  50. Miles E.A., Calder P.C. Effects of citrus fruit juices and their bioactive components on inflammation and immunity: A narrative review. Front. Immunol. 2021;12:712608.

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