Modern aspects of the clinic, diagnosis and treatment of HPV-associated penile intraepithelial neoplasia
- Authors: Chernova N.I.1, Frigo N.V.1, Markosyan T.G.2, Zadorozhnaya I.S.1
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Affiliations:
- Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology
- State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
- Issue: No 2 (2024)
- Pages: 55-59
- Section: Clinical case
- URL: https://journals.eco-vector.com/1728-2985/article/view/633555
- DOI: https://doi.org/10.18565/urology.2024.2.55-59
- ID: 633555
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Abstract
A clinical case that demonstrates the development of human papilloma virus (HPV)-associated penile intraepithelial neoplasia (PIN), namely the erythematous form of bowenoid papulosis in a young patient, as well as a delay in making a correct diagnosis due to incorrect diagnostic tactics and low alertness of doctors regarding oncologic diseases, is presented in the article. Penile intraepithelial neoplasia is the histological term for precancerous lesions of the penis. Timeliness is important in the diagnosis of PIN, since currently there is a high morbidity and mortality associated with the progression to squamous cell penile carcinoma. From the morphologic and pathogenetic standpoints, HPV-negative (differentiated) and HPV-positive subtypes of PIN are divided. The latter includes Bowenoid papulosis, erythroplasia of Queyrat and Bowen's disease. It is important to carry out a differential diagnosis between these lesions, since the rate of development of penile cancer for erythroplasia of Queyrat is 30%, for Bowen's disease is 5% and for bowenoid papulosis is 1%.
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About the authors
N. I. Chernova
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology
Author for correspondence.
Email: d.chernova@mail.ru
ORCID iD: 0000-0002-4111-6670
Ph.D., MD, Head of the Department of Anogenital Dermatosis and Sexually Transmitted Infections
Russian Federation, MoscowN. V. Frigo
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology
Email: frigo.n@mosderm.ru
ORCID iD: 0000-0001-6231-971X
Ph.D., MD, Head of the Department of Scientific and Applied Research Methods
Russian Federation, MoscowT. G. Markosyan
State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: tigranich2006@yandex.ru
ORCID iD: 0000-0003-1464-5654
д.м.н., профессор кафедры восстановительной медицины, физиотерапии Медико-биологического университета инноваций и непрерывного образования
Russian Federation, MoscowI. S. Zadorozhnaya
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology
Email: d.zadorozhnayais@mail.ru
ORCID iD: 0000-0001-7291-3149
Ph.D., junior researcher of the Department of Anogenital Dermatosis and Sexually Transmitted Infections
Russian Federation, MoscowReferences
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