Evaluation of the effect of the antioxidant complex on the processes of lipid peroxidation and antioxidant protection in men with impaired spermatogenesis who underwent a new coronavirus infection COVID-19

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Abstract

Reactive oxygen species are secondary messengers in multiple intracellular and tissue reactions, modulate the activity of mitogenic signaling pathways, and are formed predominantly in the course of metabolic activity. Both direct and indirect data on male reproductive dysfunction associated with SARSCoV-2 are described, as well as its possible pathophysiological and immunological explanations.

Purpose of the work: to evaluate the dynamics of lipid peroxidation and antioxidant protection in men after SARS-CoV-2 infection while taking an antioxidant complex.

Results. In the observed patients, the components characterizing significant damage to metabolic homeostasis were analyzed in the blood plasma: the state of lipid peroxidation was judged by the level of compounds with double bonds, ketodienes and conjugated trienes, diene conjugates, and TBA-active products in the blood. The intensity of antioxidant defense processes was assessed by the concentrations of α-tocopherol and retinol, as well as by the activity of superoxide dismutase. In the prooxidant-antioxidant system, the balance was restored towards antioxidant components in the group of patients after taking the antioxidant complex. Conclusions: the effectiveness of antioxidant correction largely depends on the degree of protection of the structure and function of cell membranes, as a result, the use of this drug is advisable, since it reduces the level of lipid peroxidation and enhances the antioxidant defense of the body.

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About the authors

N. A. Kurashova

FSPSI «Scientific center for family health and human reproduction problems»

Author for correspondence.
Email: nakurashova@yandex.ru
ORCID iD: 0000-0001-8591-8619
Scopus Author ID: 55370685900

ScD, Leading Researcher of Laboratory of Pathophysiology of Reproduction

Russian Federation, Irkutsk

B. G. Dashiev

FSPSI «Scientific center for family health and human reproduction problems»

Email: bairdashiev@mail.ru
ORCID iD: 0000-0003-2698-0687
Scopus Author ID: 56712918000

PhD, urologist-andrologist, junior researcher of the laboratory of pathophysiology of reproduction

Russian Federation, Irkutsk

S. I. Kolesnikov

FSPSI «Scientific center for family health and human reproduction problems»

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0003-2124-6328
Scopus Author ID: 7101992616

Member of the RAS, MD, ScD, Professor

Russian Federation, Irkutsk

L. I. Kolesnikova

FSPSI «Scientific center for family health and human reproduction problems»

Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0003-3354-2992
Scopus Author ID: 7005230276

Member of the RAS, MD, ScD, Professor

Russian Federation, Irkutsk

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