Pathomorphological changes in ejaculate revealed by electron transmission microscopy in patients who have had COVID-19
- Авторлар: Ibishev K.S.1, Prokop Y.O.1, Todorov S.S.1, Sinelnik E.A.1, Sizyakin D.V.1, Kogan M.I.1
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Мекемелер:
- FGBOU VO Rostov State Medical University of the Ministry of Health of the Russian Federation
- Шығарылым: № 2 (2025)
- Беттер: 50-55
- Бөлім: Andrology
- URL: https://journals.eco-vector.com/1728-2985/article/view/683342
- DOI: https://doi.org/10.18565/urology.2025.2.50-55
- ID: 683342
Дәйексөз келтіру
Аннотация
Introduction: Disturbances due to the novel coronavirus infection (COVID-19) caused economic, physical and psychological damage to the population of the whole world. The number of people who have suffered SOVID-19 is growing, and there is a number of negative consequences are documented for many organs and systems of the body, including reproductive.
Aim. To study the pathomorphological changes in ejaculate revealed by transmission electron microscopy in patients who have had COVID-19.
Materials and methods. The results of the electronic transmission microscopy of ejaculate 157 men were analyzed. They were divided into four groups. In group 1, there were 49 patients with idiopathic infertility who suffered COVID-19, group II included 42 patients with idiopathic infertility without prior of history of COVID-19, group III consisted of 39 fertile men who have had COVID-19, while in group IV there were 27 fertile men without prior of history of COVID -19.
Results. In most cases, pathological changes detected during morphological examination of patients before and after inclusion in the study were detected in the head of the sperm, which were resulted in a small specific gravity, but 12 months after infection with SARS-CoV-2, the percentage of acrosome changes increased in groups I and III. Moreover, combined pathological changes in the acrosome were recorded.
Conclusions. Thus, transmission electron microscopy revealed morphometric sperm disorders that were associated with energy processes in the cell, which naturally should be taken into account when rehabilitation of reproductive men who have had SARS-COV-2.
In addition, in patients of SARS-COV-2, a severe cell pathology was noted, due to the residualization of the cytoplasm and the pathology of mitochondria.
Негізгі сөздер
Толық мәтін

Авторлар туралы
Khalid Ibishev
FGBOU VO Rostov State Medical University of the Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: ibishev22@mail.ru
Ph.D., MD, Professor of the Department of Urology and Human Reproductive Health (with a course of pediatric urology and andrology)
Ресей, 344022, Rostov-on-Don, lane Nakhichevan, 29, buil. 9Yan Prokop
FGBOU VO Rostov State Medical University of the Ministry of Health of the Russian Federation
Email: unprocop@mail.ru
ORCID iD: 0000-0001-5340-9406
Ph.D. student at the Department of Urology and Human Reproductive Health (with a course of pediatric urology and andrology)
Ресей, 344022, Rostov-on-Don, lane Nakhichevan, 29, buil. 9Sergey Todorov
FGBOU VO Rostov State Medical University of the Ministry of Health of the Russian Federation
Email: sertodorov@gmail.com
ORCID iD: 0000-0001-8476-5606
Ph.D., MD, Head of the Department of Pathological Anatomy
Ресей, 344022, Rostov-on-Don, lane Nakhichevan, 29, buil. 9Elena Sinelnik
FGBOU VO Rostov State Medical University of the Ministry of Health of the Russian Federation
Email: 127pao.ob2@mail.ru
ORCID iD: 0000-0002-2201-5065
a doctor of the highest category, assistant of the Department of Pathological Anatomy of Rostov State Medical University
Ресей, 344022, Rostov-on-Don, lane Nakhichevan, 29, buil. 9Dmitry Sizyakin
FGBOU VO Rostov State Medical University of the Ministry of Health of the Russian Federation
Email: dsiziakin@mail.ru
ORCID iD: 0000-0002-9627-2582
Ph.D., MD, professor, professor of the Department of Urology and Human Reproductive Health (with a course of pediatric urology and andrology)
Ресей, 344022, Rostov-on-Don, lane Nakhichevan, 29, buil. 9Mikhail Kogan
FGBOU VO Rostov State Medical University of the Ministry of Health of the Russian Federation
Email: dept_kogan@mail.ru
ORCID iD: 0000-0002-1710-0169
Ph.D., MD, professor, Honored Scientist of the Russian Federation, Head of the Department of Urology and Human Reproductive Health (with a course of pediatric urology and andrology)
Ресей, 344022, Rostov-on-Don, lane Nakhichevan, 29, buil. 9Әдебиет тізімі
- Aitken R.J. COVID-19 and human spermatozoa-Potential risks for infertility and sexual transmission? Andrology. 2021;9(1):48–52.
- Ibishev Kh.S., Prokop Ya.O. New coronavirus infection: is it possible to affect men’s reproductive health. Bulletin of Urology. 2022;10(1):128–134. Russian (Ибишев Х.С., Прокоп Я.О. Новая коронавирусная инфекция: возможно ли влияние на репродуктивное здоровье мужчин? Вестник урологии. 2022;10(1):128–134).
- Kamalov A.A., Mareev V.Yu., Orlova Ya.A. et al. Androgen status in men with COVID-19 and its relationship with the course of the disease. Moscow urologist. 2021;4:2–3. Russian (Камалов А.А., Мареев В.Ю., Орлова Я.А. и др. Андрогенный статус у мужчин с COVID-19 и его связь с течением заболевания. Московский уролог. 2021;4:2–3).
- Kamalov A.A., Mareev V.Yu., Orlova Ya.A. et al. Features of the course of a new coronavirus infection and treatment options for patients depending on androgen status (founder): androgen status in men with COVID-19 and its relationship with the course of the disease. Urology. 2021;6:85–99. Russian (Камалов А.А., Мареев В.Ю., Орлова Я.А. и др. Особенности течения новой коронавирусной инфекции и варианты терапии больных в зависимости от андрогенного статуса (основатель): андрогенный статус у мужчин с COVID-19 и его связь с течением заболевания. Урология. 2021;6:85–99).
- Asfandiyarov F.R., Kruglov V.A., Vybornov S.V. et al. Post-COVID transient hypogonadism and erectile dysfunction. Experimental and Clinical Urology. 2021;14(3):112–119. Russian (Асфандияров Ф.Р., Круглов В.А., Выборнов С.В. и др. Постковидный транзиторный гипогонадизм и эректильная дисфункция. Экспериментальная и клиническая урология. 2021;14(3):112–119).
- Anifandis G., Messini C.I., Daponte A., Messinis I.E. COVID-19 and fertility: a virtual reality. Reprod Biomed Online. 2020;41(2):157–159.
- Abobaker A., Raba A.A. Does COVID-19 affect male fertility? World J Urol. 2021;39(3):975–976.
- Li D., Jin M., Bao P., Zhao W., Zhang S. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Netw Open. 2020;3(5):e208292.
- Ibishev Kh.S., Mamedov E.A., Gusova Z.R. et al. Serum testosterone levels and testicular hemodynamics before and after SARS-COV-2 infection (pilot study). Urology. 2021;5:5–9. Russian (Ибишев Х.С., Мамедов Э.А., Гусова З.Р.[и др. Показатели тестостерона в сыворотке крови и гемодинамики тестикул до и после инфицирования SARS-COV-2 (пилотное исследование). Урология. 2021;5:5–9).
- Borges do Nascimento I.J., Cacic N., Abdulazeem H.M. et al. Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis. J Clin Med. 2020;9(4):941.
- Fan C., Lu W., Li K., Ding Y., Wang J. ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Infection in COVID-19 Patients. Front Med (Lausanne). 2021;7:563893.
- Wang Z., Xu X. scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells. 2020;9(4):920.
- Shen Q., Xiao X., Aierken A., Yue W., Wu X., Liao M., Hua J. The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection. J Cell Mol Med. 2020;24(16):9472–9477.
- Ibishev Kh.S., Prokop Ya.O. Pathological findings in the spermogram of patients who have had COVID-19 and the effect of various SARS-COV-2 vaccines on spermatogenesis. Bulletin of Urology. 2023;11(1):125–133. Russian (Ибишев Х.С., Прокоп Я.О. Патологические находки в спермограмме у пациентов, перенесших COVID-19, и влияние различных вакцин от SARS-COV-2 на сперматогенез. Вестник урологии. 2023;11(1):125–133).
- Rozhivanov R.V., Andreeva E.N., Melnichenko G.A., Mokrysheva N.G. The influence of androgen status and antiandrogen therapy on the course of COVID-19 in men. Problems of Endocrinology. 2020;66(4):77–81. Russian (Роживанов Р.В., Андреева Е.Н., Мельниченко Г.А., Мокрышева Н.Г. Влияние андрогенного статуса и антиандрогенной терапии на течение COVID-19 у мужчин. Проблемы эндокринологии. 2020;66(4):77–81).
- Popova A.Yu., Gamidov S.I., Ovchinnikov R.I. et al. The Impact of COVID-19 on Fertility. What Prerequisites and Risks Will Arise in the New Reality? Consilium Medicum. 2020;22(6):73–77. Russian (Попова А.Ю., Гамидов С.И., Овчинников Р.И. и др. Влияние COVID-19 на фертильность. Какие предпосылки и риски возникнут в новой реальности? Consilium Medicum. 2020;22(6):73–77).
- Li D., Jin M., Bao P., Zhao W., Zhang S. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Netw Open. 2020;3(5):e208292.
- Ruiz-Pesini E., Diez C., Lapeña A.C., Pérez-Martos A., Montoya J., Alvarez E., Arenas J., López-Pérez M.J. Correlation of sperm motility with mitochondrial enzymatic activities. Clin Chem. 1998;44(8 Pt 1):1616–20.
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