Combined use of mirabegron and solifenacin: new standards for successful treatment of overactive bladder

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Abstract

Overactive bladder (OAB) is a common lower urinary tract disorder characterized by urgency, increased frequency, and, in some cases, urinary incontinence. Although antimuscarinic drugs (M-anticholinergics) or β3-adrenergic agonists as monotherapy provides relief to some patients, moderate treatment efficiency and tolerability often require drug switching (in case of side effects) or combination therapy (due to insufficient efficiency). The aim of this review was to analyze the combined use of mirabegron (β3-adrenergic agonist) and solifenacin (M-anticholinergic or muscarinic receptor antagonist), focusing on clinical trials, safety issues, and practical aspects. The combination therapy showed superior efficacy compared to monotherapy and an acceptable safety profile, making it a viable treatment strategy for patients with OAB who do not achieve optimal outcomes with a monotherapy.

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About the authors

Gevorg R. Kasyan

GBOU VO “Russian University of Medicine”; Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin of the Moscow City Health Department

Email: Khodyreva60@mail.ru

Ph.D., MD, Department of Urology

127006, Moscow, Dolgorukovskaya, 4; 125284, Moscow, 2nd Botkinsky proezd, 5, bldg. 20

Lyubov A. Khodyreva

GBU "Research Institute for Healthcare Organization and Medical Management" of the Moscow City Health Department

Author for correspondence.
Email: Khodyreva60@mail.ru

Ph.D., MD

Russian Federation, 115080, Moscow, Sharikopodshipnikovskaya st., 9

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