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No 1S (2016): Supplement


Male infertility

Chalyi M.E., Akhvlediani N.D., Kharchilava R.R.
Urologiia. 2016;(1S):2-17
pages 2-17 views

Erectile disfunction

Chalyi M.E., Akhvlediani N.D., Kharchilava R.R.
Urologiia. 2016;(1S):18-27
pages 18-27 views

The male factor in childless marriage - problemsolving strategies

Bozhedomov V.A.


This paper proposes a three-level care system for men from involuntarily childless couples. The proposal is based on the experience of federal and regional clinics of urology and gynecology, respective departments for postgraduate education and on the analysis of scientific literature. Using three-stage comprehensive prevention of male infertility factor and recurrent pregnancy loss is substantiated. Up-to-date requirements for equipping andrology laboratories and testing sperm quality are outlined. The prospects and limitations of surgical and medical treatment modalities and assisted reproductive technologies are described.
Urologiia. 2016;(1S):28-34
pages 28-34 views

Rol' muzhchiny v privychnom nevynashivanii beremennosti u suprugi

Gamidov S.I., Ovchinnikov R.I., Popova A.Y., Golubeva O.N., Ushakova I.V.


In a review article based on the published literature and their own research, the authors examine the role of a man in recurrent miscarriage and reproductive losses in a spouse. Detailed description is presented of the negative impact of elevated levels of sperm DNA fragmentation on the course of pregnancy, especially during the first trimester, on the occurrence of recurrent miscarriage or missed abortion, on the effectiveness of assisted reproductive technology (ART) programs. The etiology and pathogenesis of damage to sperm DNA are described. Outlined are positive effects of correcting adverse lifestyle factors, the role of varicocelectomy and antioxidant therapy, and advances in ART. The review specifies the role of different male karyotype abnormalities (translocations) in the pathogenesis of pregnancy loss. The implications of urologic surgery, preimplantation genetic diagnosis in solving this problem are discussed. New treatment strategies using correction of male disorders for couples with recurrent miscarriage are offered.
Urologiia. 2016;(1S):35-43
pages 35-43 views

Cell technologies' application in practical andrology

Glybochko P.V., Alyaev Y.G., Chalyi M.E., Epifanova M.V., Krasnov A.O.


The articIe is devoted to new methods for treating men's erectiIe dysfunction using pIateIet-rich auto pIasma and adipose tissue stromaI vascuIar fraction. RecentIy, there has been increased interest in these methods due to their high level of efficiency and safety. Platelet-rich auto plasma and adipose tissue stromal vascular fraction have been successfully appIied in different medicaI fieIds - traumatoIogy, orthopedics, pIastic surgery, etc. At the same time, efficacy and safety of these technologies has not yet been clinically studied from the perspective of evidence-based medicine.
Urologiia. 2016;(1S):44-46
pages 44-46 views

Results of a multicenter non-interventional study on the efficacy and safety of NeyroDoz® complex for sexual dysfunction in men

Kamalov A.A., Khodyreva L.A., Dudareva A.A., Davidov M.I., Kuz'min M.D., Okhobotov D.A., Starosel'skaya M.A., Karpov V.K.


The article presents the results of a multi-center observational study carried out in 2014-2015 comprising 630 male patients from 23 Russian health care institutions. The study aimed to accumulate epidemiological data on sexual dysfunction in men and test the efficacy and safety of biologically active complex NeyroDoz®. Data for the study were collected using questionnaires. The study findings showed a high prevalence of premature ejaculation (PE) in 38.2% of patients with chronic prostatitis (CP) and in 33.25% of patients with erectile dysfunction (ED). The data were analyzed for the total study population (n=630) and separately for three groups of patients selected according to the presence of PE (n=582), orgasmic disorders without PE (n=17) and increased anxiety related to urological diseases without PE (n=31). In all patients of the study, NeyroDoz® intake produced a statistically significant increase in the intensity of orgasm from 5,0±2,2 to 7,6±1,8 points, duration of sexual intercourse from 3,3±5,4 to 6,5±4,8 min, and satisfaction with sexual intercourse from 1,4±0,7 to 3,1±1,1 points. In 81% of PE patients the duration of penetration phase of sexual intercourse increased by 50% of the baseline values. The intensity of orgasm increased on average by 60% and 75% in men with PE and orgasm disorders without PE, respectively. Reduction of psycho-emotional burden was observed in 90% of patients with anxiety and depression. The dietary supplement NeyroDoz® showed clinical efficacy and safety in the combined treatment of sexual dysfunction in men.
Urologiia. 2016;(1S):47-53
pages 47-53 views

Stimulation of a spermatogenesis in men at a pathospermia and infertility

Rozhivanov R.V., Kravtsova N.S., Kurbatov D.G.


The combined therapy of HCG in combination with recombinant FSH is al most effective. At the same time the studied types of the stimulating therapy are safe and don't lead to development of side effects. The purpose: to investigate of the methods of treatment, directed on increase in quantity of spermatozoa in an ejaculate. Matherials and methods: for this purpose used clomifene and combinations of recombinant FSH with chorionic gonadotrophin (HCG) in 60 men with infertility. Results: Efficiency of monotherapy by clomiphene was higher and made 20% for conception, and 63% for oligoteratozoospermia. Efficiency of the combined therapy of HCG in combination with recombinant FSH was 40% for conception, and 87% for oligoteratozoospermia. The efficiency of the combined therapy by recombinant FSH and HCG in cases of the previous inefficiency monotherapy HCG and clomifene for oligoteratozoospermia made 65%.
Urologiia. 2016;(1S):54-59
pages 54-59 views

Comparing efficacy of selective penile denervation and circumcision for primary premature ejaculation

Alyaev Y.G., Akhvlediani N.D.


Objective: To compare the efficacy and safety of selective penile denervation to that of circumcision for primary premature ejaculation (PPE). Materials and methods. A prospective study comprised 138 patients with PPE, divided into two groups. Patients in Group 1 (n=50) underwent selective penile denervation by dissecting about a half of dorsal penile nerve branches. Large nerves (> 2 mm) were subjected to microsurgical neurorrhaphy. In group 2 (n=88) circumcision was carried out using guillotine technique. The evaluation of treatment efficacy was carried out using the Criteria for premature ejaculation questionnaire (CriPE), measuring intravaginal ejaculation latency time (IELT) with a stopwatch and testing penile vibration sensitivity. These examinations were performed at baseline and after 2, 4, 6, 8, 10 and 12 months after operation. Results. By the end of follow-up, 88% and 10.2% of patients of group 1 and group 2 had no signs of PPE, respectively. At 12 months IELT index increased 6-fold in patients of group 1 from 53,6±12,7 to 335,6±81,5 seconds, while remaining unchanged in group 2 with 51,8±10,4 seconds at baseline and 53.9±20.1 seconds at the end of follow-up. Group 1 showed statistically significant and sustained reduction in penile vibration sensitivity compared with baseline (p<0,001). In group 2, the baseline and endpoint characteristics of bio-tensiometry did not differ significantly (p>0,05). Conclusions. The resulting effectiveness of selective penile denervation and circumcision for PPE was 88% and 10.2%, respectively, with comparable safety.
Urologiia. 2016;(1S):60-64
pages 60-64 views

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