No 2S (2016): Supplement

Aim. To compare the results of population studies conducted in the Russian Federation to identify the prevalence, severity and risk factors for urinary disorders in men. Materials and methods. Data of a survey of 1083 men were analyzed for the age, weight, height, comorbidities with their signs and symptoms, history of surgery on pelvic organs, copulative disorders, and IPSS and quality of life scores. The findings were compared with the results of a survey of 482 Russian men under the protocol of the International Society of Continence (ICS) aimed to identify patients with overactive bladder (OAB), in whom pollakiuria, nocturia, urgency, urinary incontinence, stress-incontinence, poor flow and terminal dribbling were registered. Results. According to findings on IPSS scores voiding disorders were diagnosed in 649 (59.9%) of respondents, with mild, moderate and severe lower urinary tract symptoms (LUTS) in 370 (34.2%), 216 (19.9 %) and 63 (5.8%) men, respectively; mean IPSS score was 5,0±7,0. Among men with LUTS 34.6% were not satisfied with their quality of life. The severity of LUTS was greater among older respondents (tB = 0,441; p<0,001), having a high body mass index (tB = 0,119; p<0.001), ischemic heart disease (tB = 0,231; p<0,001), hypertension (tB = 0,240; p<0,001), diabetes mellitus (tB = 0,158; p<0,001), obesity (tB = 0,151; p<0,001), history of surgery on pelvic organs (tB = 0,259; p<0,001), suffering from erectile dysfunction (tB = 0,126; p<0,001). 116 (24.1%) men surveyed under ICS protocol had LUTS consistent with OAB criteria. Symptoms of urine storage, emptying and postmicturition symptoms were found in 299 (62%), 164 (34%) and 106 (22%) patients, respectively and were more common in older men. 236 (48.9%) of respondents experienced discomfort or pain, in 72 (15%) - LUTS resulted in decreased sexual activity, but only 149 (30.9%) of men sought treatment. Conclusions. LUTS in Russia are common among men of any age. They reduce the quality of life, closely associated with erectile dysfunction, metabolic disorders and diseases. Men with urinary disorders need a comprehensive examination and treatment based on an interdisciplinary approach.

Introduction. Urinary urgency is a hallmark symptom of overactive bladder (OAB). Several scales have been used to measure urgency. Taking into account the exceptional importance of these scales, it is important to determine their reliability, which depends directly on the accuracy of the wording and clarity to patients. Aim. To determine reliability of Russian-language translation of the Patient Perception of Intensity of Urgency Scale (PPIUS) in identifying and assessing urgency in patients with OAB. Materials and methods. The study included 50 patients (46 women and 4 men) aged 19 to 70 years (mean age 56.5 years). At the time of entering the study, all patients had symptoms of OAB and received anticholinergic therapy for at least 3 months with any drug approved for the use in Russia. PPIUS scale validation was performed by assessing reliability, absence of "habituation" effect of and indicators of convergent, divergent, and content validity. Results. The Russian version of voiding diary with PPIUS scale was found to have good psychometric properties and besides the content validity also had significant signs of convergent and divergent validity. Conclusion. The Russian-language versions of urgency scales PPIUS and TUFS can be considered validated for using in clinical practice and in clinical and non-interventional studies in patients with OAB in Russia.

The article presents summarized results of domestic and international studies of the genetic aspects of urolithiasis. The presented evidence suggests the importance of early and accurate molecular genetic diagnostics of hereditary diseases associated with stone formation for timely treatment and prevention for patients' relatives. Also provided are examples of using molecular genetic diagnostics in urologist's practice for monogenic and multifactorial diseases associated with stone formation. Taken together, these results show that using modern post-genomic technologies for assessing the risk of hereditary predisposition to urolithiasis is justified.