Calcium antagonist effects on contractile ureteral activity in experiment
- Авторлар: Komyakov BK1, Bat'ko AB1, D'yachuk GI1, Komyakov BK1, Batko AB1, Diachuk GI1
-
Мекемелер:
- Шығарылым: № 6 (2010)
- Беттер: 23-27
- Бөлім: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/277797
- ID: 277797
Дәйексөз келтіру
Толық мәтін
Аннотация
Dihydropiridine (nifedipine), phenilalkilamine (isoptin) and a novel domestic calcium channel blocker A-29 were studied for effects on motor activity of an isolated segment of a rabbit ureteral upper-third. Strength of muscular contractions (134 measurements) was evaluated in per cents to the baseline level. Tonic reaction and its duration were measured. Calcium antagonist action on ureteral contractile activity was studied by changes in contractile power in concentration rage from 10-9 to 10-5 M/l. Beginning from 10-9 M/l concentration of all the drugs studied there was a gradual decline of the initial contractile activity of the ureter. The following concentrations of calcium antagonists significantly reduced the amplitude of phasic contraction, whereas therapeutic concentrations - by more than 40%. In elevation of the concentration in some cases washing of the isolated ureteral segment with Krebs' solution failed to reestablish tonic reaction. Only A-29 spontaneous contractile activity recovered after washing. The maximal effect was achieved with nifedipin and A-29 in concentrations 10-5 M/l. Thus, calcium antagonists change contractile activity of smooth muscle cells of the ureter with a dose-dependent effect making it possible to use calcium antagonists for inhibition of contractile ureteral activity in clinical practice.
Негізгі сөздер
Әдебиет тізімі
- Аполихин О. И., Какорина Е. П., Сивков А. В. и др. Состояние урологической заболеваемости в Российской Федерации по данным официальной статистики. Урология 2008; 3: 3-10.
- Бакунц С. А. Вопросы физиологии мочеточников. Л.; 1970.
- Ходырева Л. А., Мудрая И. С. Уродинамика верхних мочевыводящих путей у больных мочекаменной болезнью и хроническим пиелонефритом. Урология 2007; 2: 16-21.
- Кочемасова Н. Г., Тараненко В. М. Влияние повышенной концентрации ионов кальция на электрическую и сократительную активность гладких мышц мочеточника морской свинки. Бюл. экспер. биол. 1977; 5: 522-526.
- Тиктинский О. Л., Александров В. П. Мочекаменная болезнь. СПб.; 2000.
- Ghoniem G. M., Dilworth J. P., Roberts J. A. Effect of nifedipine on kidney and ureteral function after experimental acute unilateral ureteral obstruction. Urology, 1993; 41 (5): 484-488.
- Maggi C. A., Giuliani S. A pharmacological analysis of calcium channels involved in phasic and tonic responses of the guinea-pig ureter to high potassium. J. Auton. Pharmacol. 1995; 15 (1): 55-64.
- Sahin A., Erdemli I., Bakkaloglu M. The effect of nifedipine and verapamil on rhythmic contractions of human isolated ureter. Arch. Int. Physiol. Biochim. Biophys. 1993; 101 (5): 245-247.
- Borghi L., Meschi Т., Amato F. Nifedipine and methylprednisolone in facilitating ureteral stone passage: a randomized, double-blind, placebo-controlled study. J. Urol. (Baltimore). 1994; 152 (4): 1095-1098.
- Крутецкая З. И., Лебедев О. Е., Курилова Л. С. Механизмы внутриклеточной сигнализации. СПб.; 2003.
- Berridge M. J., Bootman M. D., Lipp P. Calcium - a life and death signal. Nature 1998; 395: 645-648.
- Волобуев А. Н., Неганов В. А., Романчук П. И. Анализ влияния антагонистов кальция на мышечный тонус. Вестн. новых мед. технол. 1997; 3: 51-54.
- Берлин Г. С. Механотронные преобразователи и их применение. М.; 1974.
Қосымша файлдар
