HIGH-INTENSITY FOCUSED ULTRASOUND (HIFU) FOR THE PROSTATE CANCER TREATMENT: 5-YEAR RESUTS


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Abstract

During 2007-2012 748 patients with prostate cancer (PCa) underwent ultrasound ablation (HIFU). Patients were divided into 3 groups according to the prevalence and risk of disease progression: low risk (localized prostate cancer, 465 (62%) of patients) stage T1-2N0M0, total Gleason score ≤6, the level of prostate-specific antigen (PSA) less than 20ng/ml), high risk (locally advanced prostate cancer, 251 (34%) of patients) - stage T2-3N0M0, total Gleason score ≤9, the PSA level from 20 to 60 ng/ml, the presence of local recurrence after radical prostatectomy (RPE) and external beam radiation (EBRT) - 32 (4%) patients. Median follow-up after HIFU-therapy was 36 (3-54) months. At 12 and 48 months after treatment in patients with a low risk of progression median PSA was 0.2 and 0.5 ng/ml, in the group with a high risk 0.8 and 1.2 ng/ml, in patients with local recurrence after RPE and EBRT - 0.5 and 1.7ng/ml respectively. Generally HIFU treatment was successful in 90.9% of patients. It is shown that HIFU is safe minimally invasive treatment for localizes and locally advanced prostate cancer. It can be successfully performed in patients with local recurrence after RPE and EBRT.

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