Phenotypic and molecular genetic properties of Escherichia coli clinical strains isolated from patients with urological diseases


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. Microbiological and molecular genetic characterization resistance profiles of Escherichia coli strains isolated in a pilot singlecenter clinical study from patients of the urological department in Yaroslavl in 2016-2017. Materials and methods. Clinical strains of E. coli (n=18) were isolated from the urine of women aged 23-84 years. The mobility of bacteria, colicinogenicity, and sensitivity to lactobacilli antagonism, biofilm formation, and susceptibility to antimicrobials were evaluated. The antibiotic resistance genes were identified. Results. The E. coli strains had a wide heterogeneity in mobility, colicinogenicity, and biofilm formation. They were sensitive to Lactobacillus acidophilus antagonism, as well as to nitrofurantoin, meropenem, fosfomycin and the main functional classes of disinfectants and antiseptics, but are resistant to beta-lactams, fluoroquinolones and aminoglycosides. The mcr-1 gene providing resistance to colistin was identified in two strains. Conclusions. Analysis of genetic antibiotic resistance determinants revealed the genetic diversity of clinical E. coli strains. The obtained data on the strain sensitivity to antibacterials and disinfectants can be used by clinicians in choosing the optimal antibiotic therapy and treatment of abiotic surfaces in urological departments.

Толық мәтін

Рұқсат жабық

Авторлар туралы

P. Slukin

State Research Center for Applied Microbiology and Biotechnology

E. Svetoch

State Research Center for Applied Microbiology and Biotechnology

E. Aslanyan

State Research Center for Applied Microbiology and Biotechnology

E. Astashkin

State Research Center for Applied Microbiology and Biotechnology

M. Ershova

Infectious Clinical Hospital No. 1, Yaroslavl

E. Poletaeva

Infectious Clinical Hospital No. 1, Yaroslavl

A. Shepelin

State Research Center for Applied Microbiology and Biotechnology

N. Fursova

State Research Center for Applied Microbiology and Biotechnology

Әдебиет тізімі

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