Pathomorphological criteria for the differential diagnosis of leukoplakia and chronic recurrent papillomavirus cystitis

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Introduction: According to the literature of recent years, there has been an increased interest in non-oncological diseases of the bladder, between which differential diagnostics have to be carried out in order to determine a plan for the diagnosis and treatment of patients with these nosologies. There are often certain difficulties in the differential diagnosis of some forms of viral cystitis and leukoplakia

Objective: to determine pathomorphological criteria for the differential diagnosis of leukoplakia and chronic recurrent papillomavirus cystitis.

Materials and methods: The prospective study included 85 sexually active patients aged 20–45 years, who were divided into two groups depending on the etiological factor. Patients of group I (n=70) – with chronic recurrent cystitis (CRC) of papillomavirus (PV) etiology, group II (n=15) – with leukoplakia. All patients were examined in accordance with the recommendations of the European Association of Urology (EAU) and the Russian Society of Urology (ROU); an additional endoscopic examination of the bladder (cystoscopy) was performed, followed by a morphological examination of the bladder biopsy.

Results: A morphological examination of biopsy tissue in all patients of group I revealed koilocytic transformation of the urothelium combined with non-keratinizing metaplasia of the urothelium, and in patients of group II, in all cases, keratinizing metaplasia of the urothelium with hyperkeratosis was detected.

Conclusion: Morphological examination is the gold standard in differential leukoplakia and chronic recurrent papillomavirus cystitis

Толық мәтін

Рұқсат жабық

Авторлар туралы

Kh. Ibishev

Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of Russia

Хат алмасуға жауапты Автор.
Email: ibishev22@mail.ru
ORCID iD: 0000-0002-2954-842X

M.D., Dr. Sc. (Med), Full Prof., Prof. Dept. of Urology, Pediatric Urology & Reproductive Health

Ресей, Rostov-on-Don

T. Lapteva

State Autonomous Institution of the Rostov Region «Regional Consultative and Diagnostic Center» of the Ministry of Health of Russia

Email: Lto-96@yandex.ru
ORCID iD: 0000-0002-6544-6113

M.D., Pathologist, Pathology Division

Ресей, Rostov-on-Don

S. Todorov

Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of Russia

Email: sertodorov@gmail.com
ORCID iD: 0000-0001-8476-5606

Dr. Sc. (Med.), Associate Professor of the Department of Operative Surgery, Clinical Anatomy and Pathological Anatomy, head of the morphological department of the clinic, pathologist of the highest category

Ресей, Rostov-on-Don

I. Goncharov

Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of Russia

Email: ilagoncarov11250@gmail.com
ORCID iD: 0009-0005-0770-7230

resident of the Department of Urology and Human Reproductive Health (with a course of pediatric urology-andrology)

Ресей, Rostov-on-Don

A. Alkhashash

Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of Russia

Email: Ahmadalhashash95@gmail.com
ORCID iD: 0009-0002-8983-3107

postgraduate student of the Department of Urology and Human Reproductive Health (with a course of pediatric urology-andrology)

Ресей, Rostov-on-Don

V. Mamedov

Federal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Health of Russia

Email: mamedov1007@yandex.ru
ORCID iD: 0000-0001-5508-4510

M.O. Urologist, Postgraduate student, Dept. of Urology and Human Reproductive Health (with Podiatrie Urology and Andrology Course)

Ресей, Rostov-on-Don

Әдебиет тізімі

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Қосымша файлдар

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Әрекет
1. JATS XML
2. Fig. 1. Cystoscopy. Exophytic formations of the bladder

Жүктеу (97KB)
3. Fig. 2. Cystoscopy. Leukoplakia of the bladder

Жүктеу (154KB)
4. Fig. 3. Morphological examination. Pathological restructuring of urothelial cells: papillomatous hyperplasia with signs of HIV infection (coilocytosis, discariasis). [N&E, uv. x200]

Жүктеу (167KB)
5. Fig. 4. Morphological examination. Pathological restructuring of urothelial cells: squamous cell metaplasia with keratinization, hyperkeratosis [N&E, uv. XI00]

Жүктеу (190KB)
6. Fig. 5. Morphological examination. Pathological restructuring of urothelial cells: squamous cell metaplasia with eosinophilic staining of the squamous hyperkeratotic (glycogenized) squamous epithelium [N&E, uv. X100]

Жүктеу (146KB)

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