Reflux nephropathy in children: pathogenesis and prognosis. Part 2


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Resumo

The second part of this review is devoted to the issues of modern and promising diagnosis of RN in children. The advantages and limits of the available methods for recording the structural and functional state of the kidneys in childhood are considered. Particular attention is paid to possibilities non-invasive methods for diagnosis and prediction of the disease course. Data on promising biomarkers of the early stages of RN formation and progression are presented. For the purpose of a comprehensive and adequate assessment of morphological changes in the kidneys, the necessity of studying various combinations of cytokines in biological media with the subsequent determination of the optimal spectrum is shown. The sensitivity and specificity of molecular indicators of renal damage reviewed as potential targets for renoprotective therapy in the nearest future.

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Sobre autores

O. Morozova

Sechenov First Moscow State Medical University(Sechenov University)

Email: morozova_ol@list.ru
Doctor of Medical Sciences, professor, Department of Pathophysiology Moscow, Russia

D. Lakomova

Saratov State Medical University n. a. V.I. Razumovsky

Email: dlmedic@mail.ru
Ph.D., associate professor at the Department of Pediatric Surgery Saratov, Russia

N. Zakharova

Sechenov First Moscow State Medical University(Sechenov University)

Email: lipidgormon@mail.ru
Doctor of Medical Sciences, professor, Department of clinical and laboratory diagnostics Moscow, Russia

L. Maltseva

Sechenov First Moscow State Medical University(Sechenov University)

Email: lamapost@mail.ru
Ph.D., associate professor at the Department of Pathophysiology Moscow, Russia

Z. Manasova

Sechenov First Moscow State Medical University(Sechenov University)

Email: butri78@mail.ru
Ph.D., associate professor at the Department of Pathophysiology Moscow, Russia

D. Morozov

Sechenov First Moscow State Medical University(Sechenov University)

Email: damorozov@list.ru
MD, professor at the Department of Pediatric Surgery, Urology and Andrology Moscow, Russia

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