Multiple Schwannoma of the scrotum: a clinical case

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Resumo

Schwannoma is a benign tumor arising from the peripheral nerve sheaths and consisting of highly differentiated Schwann cells, which under physiological conditions produce the essential component of nerve fibers myelin. Frequent localization of neoplasms are areas with developed and abundant nerve supply – the head, neck, limbs, less often its occur in the chest, mediastinum, retroperitoneum, adrenal glands, organs of the gastrointestinal tract, cases of schwannoma of the penis and vulva are also described. In clinical practice, extratesticular schwannoma of the scrotum is extremely rare, when analyzing literary sources, descriptions of only isolated observations were found. Scrotal schwannoma is often associated with systemic pathology – neurofibromatosis type 2 or schwannomatosis, isolated development of the tumor is rather considered an exceptional event. In this article, we present a description of a clinical case of multiple large scrotal schwannoma in a 45-year-old man who underwent surgical treatment with excision of the tumor in 2011. During the period 2011–2024, the patient had no relapse of the disease, the quality of life was high and the prognosis was favorable.

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Sobre autores

Vacheslav Boshchenko

Siberian State Medical University, Ministry of Health of Russia

Email: vsbosh@mail.ru
ORCID ID: 0000-0002-2448-9870
Código SPIN: 2110-8227

Dr.Med.Sci., Head of the Department of Common and Children Urology-Andrology, Federal State Budgetary Educational Institution of Higher Education

 

Rússia, Moskovsky trakt, 2, Tomsk 634050

Daniil Mikhailovskiy

Siberian State Medical University, Ministry of Health of Russia

Email: di_mi_14@mail.ru
ORCID ID: 0009-0009-8900-5097

resident of the Department of Common and Children Urology-Andrology, Federal State Budgetary Educational Institution of Higher Education «Siberian State Medical University»

Rússia, Moskovsky trakt, 2, Tomsk 634050

Nadezhda Krakhmal

Siberian State Medical University, Ministry of Health of Russia; Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Autor responsável pela correspondência
Email: krakhmal@mail.ru
ORCID ID: 0000-0002-1909-1681
Código SPIN: 1543-6546

Cand.Med.Sci., Assistant of Professor of the Pathology Department of Federal State Budgetary Educational Institution of Higher Education, Senior Researcher of the Department of General and Molecular Pathology Cancer Research Institute

Rússia, Moskovsky trakt, 2, Tomsk 634050; Kooperativny street, 5, Tomsk 634009

Sergey Vtorushin

Siberian State Medical University, Ministry of Health of Russia; Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: wtorushin@rambler.ru
ORCID ID: 0000-0002-1195-4008
Código SPIN: 2442-4720

Dr.Med.Sci., Professor of the Pathology Department of Federal State Budgetary Educational Institution of Higher Education «Siberian State Medical University», Head of the Department of General and Molecular Pathology Cancer Research Institute

Rússia, Moskovsky trakt, 2, Tomsk 634050; Kooperativny street, 5, Tomsk 634009

Bibliografia

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2. Fig. 1. Ultrasound data of a scrotal tumor in different sections in B-mode A — multiple encapsulated nodular structures of a scrotal tumor of various sizes. B — larger nodular structures of a scrotal tumor.

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3. Fig. 2. Scrotal tumor. A — excision of scrotal tumor with skin flap and soft tissues (photo during surgery). B — removed scrotal tumor (macro specimen).

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4. Fig. 3. Morphology and results of immunohistochemical study of scrotal tumor A, B — scrotal tumor, represented by nodular formations of spindle-shaped structure with distinct contours, with intertwined bundles and cords of elongated cells, in many areas with the formation of typical rhythmic structures like dense "swirls"; hematoxylin and eosin, magnification ×4 (A), ×10 (B). C, D — immunohistochemical reaction, positive diffuse nuclear expression of SOX10 in tumor cells; magnification ×10 (C), ×20 (D). D, E — immunohistochemical reaction, positive diffuse nuclear and cytoplasmic expression of S100 in tumor cells; magnification ×4 (D), ×20 (E). W, 3 — immunohistochemical reaction, positive nuclear expression of ki67 in single tumor cells; magnification × 10 (W), × 40 (3).

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