Use of high-dose vitamin C and Suby G solution in the treatment of encrusted cystitis

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Resumo

This article describes a clinical case of the successful use of high doses of vitamin C and Suby G solution to reduce urine acidity in a patient with encrusted cystitis. The previously used combination of oral methionine intake and intravesical instillations of a 3% aqueous boric acid solution was ineffective. As part of comprehensive therapy, transurethral resections of bladder wall encrustations were performed, along with antibacterial therapy with vancomycin. The obtained results indicate the potential effectiveness of this combination; however, further clinical studies are needed to verify them.

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Sobre autores

Inga Kosova

Russian Medical Academy of Continuous Professional Education; Demikhov City Clinical Hospital (branch №2)

Email: kosovainga@mail.ru
ORCID ID: 0000-0002-0051-0583

M.D., Dr. Med. Sc., Assoc. Prof., Professor at the Department of Urology and Surgical Andrology, Urologist at the Department of Urology (branch №2)

Rússia, Moscow; Moscow

Vagan Barsegian

European Medical Center

Autor responsável pela correspondência
Email: vaganbarsegyan@gmail.com
ORCID ID: 0000-0003-0592-3181

M.D., Ph.D., Urologist, Urology Clinic

Rússia, Moscow

Oleg Loran

Russian Medical Academy of Continuous Professional Education

Email: oleg_loran@gmail.com
ORCID ID: 0000-0002-7531-1511

Academician of the RAS, Dr. Med. Sc, Professor, Chief of the Department of Urology and Surgical Andrology

Rússia, Moscow

Vladimir Saenko

Sechenov University

Email: saenko_vs@staff.sechenov.ru
ORCID ID: 0000-0003-3107-8161

M.D., Dr. Med. Sc., Assoc. Prof., Professor at the Institute of Urology and Human Reproductive Health

Rússia, Moscow

Dmitriy Kolbasov

Demikhov City Clinical Hospital (branch №2)

Email: urology68@rambler.ru

M.D., Ph.D., Chief of the Department of Urology №2

Rússia, Moscow

Nikolay Grigoriev

European Medical Center

Email: ngrigoriev@emcmos.ru

M.D., Dr. Med. Sc., Professor, Chief of the Urology Clinic, Chief of the Department of Urology, EMC Medical School

Rússia, Moscow

Bibliografia

  1. Van de Perre E, Reichman G, De Geyter D, Geers C, Wissing KM, Letavernier E. Encrusted Uropathy: A Comprehensive Overview-To the Bottom of the Crust. Front Med (Lausanne). 2021 Jan 21;7:609024. doi: 10.3389/fmed.2020.609024. PMID: 33553205; PMCID: PMC7858656.
  2. Fu JG, Xie KJ. Successful treatment of encrusted cystitis: A case report and review of literature. World J Clin Cases. 2020 Sep 26;8(18):4234-4244. doi: 10.12998/wjcc.v8.i18.4234. PMID: 33024784; PMCID: PMC7520765.
  3. Gadzhiev N.K., Malikiev I.E., Obidnyak V.M. et al. The Problem of Clinical Diagnostics and Treatment of Incrusting Cystitis. Urology. 2022;5:142–146. doi: 10.18565/urology.2022.5.142-146. EDN PJJTYW. Russian (Гаджиев Н.К., Маликиев И.Е., Обидняк В.М. и др. Проблема клинической диагностики и лечения инкрустирующего цистита. Урология. 2022;5:142–146. doi: 10.18565/urology.2022.5.142-146. EDN PJJTYW).
  4. Kosova I.V., Barsegian V.A., Loran O.B. et al. Etiological factors in the development of urinary disorders in women. Consilium Medicum. 2022;24(7):451–455. doi: 10.26442/20751753.2022.7.201791. EDN CPEKHD. Russian (Косова И.В., Барсегян В.А., Лоран О.Б. и др. Этиологические факторы развития нарушений мочеиспускания у женщин. Consilium Medicum. 2022;24(7):451–455. doi: 10.26442/20751753.2022.7.201791. EDN CPEKHD).
  5. Barsegian V.A., Kosova I.V. Role of the lower urinary tract viral infections in the development of female micturition disorders. Urology. 2022;5:117–122. doi: 10.18565/urology.2022.5.117-122. EDN PXSTHU. Russian (Барсегян В.А., Косова И.В. Роль вирусных инфекций нижних мочевыводящих путей в развитии нарушений мочеиспускания у женщин. Урология. 2022;5:117–122. doi: 10.18565/urology.2022.5.117-122. EDN PXSTHU).
  6. Soriano F., Tauch A. Microbiological and clinical features of Corynebacterium urealyticum: urinary tract stones and genomics as the Rosetta Stone. Clin Microbiol Infect. 2008;14(7):632–43. doi: 10.1111/j.1469-0691.2008.02023.x. PMID: 18558935.
  7. Perrucci E., Lancellotta V., Benedetto M.D., Palumbo I., Matrone F., Chiodi M., Lombi R., Marcantonini M., Mariucci C., Aristei C. Encrusted cystitis after definitive radiotherapy for cervical cancer: a case report. J Contemp Brachytherapy. 2016;8(6):541–543. doi: 10.5114/jcb.2016.62958. PMID: 28115961; PMCID: PMC5241373.
  8. Benoit G., Eschwege P., Paradis V., Droupy S., Nordmann P., Charpentier B. Successful treatment of encrusted pyelitis in a renal transplant with local acidification and surgical ileocaliceal anastomosis. J Urol. 1999;162(4):1369–70. PMID: 10492200.

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2. Fig. 1. CT scan of the urinary system organs with intravenous contrast. A — the proximal curl of the internal ureteral stent on the right, B — multiple concretions of the left kidney

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3. Fig. 2. CT scan of the urinary system organs with intravenous contrast. Uneven calcification of the bladder mucosa

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4. Fig. 3. Cystoscopic picture. Encrustations on the mucous membrane of the bladder

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5. 4. Cystoscopic picture 2 months after the start of treatment

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