ИНТРАПРОСТАТИЧЕСКОЕ ИНЪЕЦИРОВАНИЕ 96% ЭТАНОЛА В ЭКСПЕРИМЕНТАЛЬНОЙМОДЕЛИ НА ЖИВОТНЫХ
- Авторы: Мартов ЛГ1, Павлов ДА1, Кирпатовский ВИ1, Кудрявцев ЮВ1
-
Учреждения:
- НИИ урологииМЗ и СР РФ, Москва
- Выпуск: № 6 (2004)
- Страницы: 21-26
- Раздел: Статьи
- URL: https://journals.eco-vector.com/1728-2985/article/view/276238
- ID: 276238
Цитировать
Полный текст
Аннотация
Transurethral intraprostatic injection of ethanol (HE) is a new
low-invasive method in the treatment of benign prostatic hyperplasia
(BPH). We made dog and rat experiments to prove safety and efficacy
of HE. The experiment was made on 10 rats and 10 dogs injected
transurethrally (Prostaject device) with 96% ethyl alcohol in 10% volume
of estimated volume of the prostate. The injection was followed
by measurement of blood alcohol, the test for hemolysis. Transurethral
ultrasound control of prostate size 1, 3 and 6 months after the
injection and histological examinations 1, 3, 7, 14 days and 1, 3 and
6 months after the injection were made. It was found that blood alcohol
after the above injection was not elevated. Necrosis was documented
in all the cases but subsequently the necrotic site was replaced
with sclerotic tissue. The necrosis involved only the prostatic capsule.
The size of the prostate diminished by 29%. Thus, transurethral injection
of ethyl alcohol (10% of prostate size) is safe and effective in
achievement of prostatic gland ablation. Therefore, clinical trials of
the method in patients with benign prostatic hyperplasia are justified
low-invasive method in the treatment of benign prostatic hyperplasia
(BPH). We made dog and rat experiments to prove safety and efficacy
of HE. The experiment was made on 10 rats and 10 dogs injected
transurethrally (Prostaject device) with 96% ethyl alcohol in 10% volume
of estimated volume of the prostate. The injection was followed
by measurement of blood alcohol, the test for hemolysis. Transurethral
ultrasound control of prostate size 1, 3 and 6 months after the
injection and histological examinations 1, 3, 7, 14 days and 1, 3 and
6 months after the injection were made. It was found that blood alcohol
after the above injection was not elevated. Necrosis was documented
in all the cases but subsequently the necrotic site was replaced
with sclerotic tissue. The necrosis involved only the prostatic capsule.
The size of the prostate diminished by 29%. Thus, transurethral injection
of ethyl alcohol (10% of prostate size) is safe and effective in
achievement of prostatic gland ablation. Therefore, clinical trials of
the method in patients with benign prostatic hyperplasia are justified
Об авторах
Л Г Мартов
НИИ урологииМЗ и СР РФ, МоскваНИИ урологииМЗ и СР РФ, Москва
Д А Павлов
НИИ урологииМЗ и СР РФ, МоскваНИИ урологииМЗ и СР РФ, Москва
В И Кирпатовский
НИИ урологииМЗ и СР РФ, МоскваНИИ урологииМЗ и СР РФ, Москва
Ю В Кудрявцев
НИИ урологииМЗ и СР РФ, МоскваНИИ урологииМЗ и СР РФ, Москва
Список литературы
- Ditrolio J., PaelP., Watson R. A., Irwin R. J. Jr. Chemo-ablation of the prostate with dehydrated alcohol for the treatment of prostatic obstruction. J. Urol. (Baltimore) 2002; 167: 2100.
- Watson R. A., Patel P., DiTrolio J. V. Transurethral ethanol ablation of the prostate. J. Urol. (Baltimore), 1999; 161: 304 (abstr. 1173).
- Gelezer R. K., Charbonneau J. W., Hussain S. et al. Complications of percutaneous ethanol ablation. J. Ultrasound Med. 1998; 17: 531.
- Schumm-Draeger P. M. Ultrasound-guided percutaneous ethanol injection in the treatment of autonomous thyroid nodules: a review. Exp. Clin. Endocrinol. Diabetes, 1998; 106 (suppl.): S 59.
- Livraghi Т., Festi D., Monti F. et al. US-guided percutaneous alcohol injection of small hepatic and abdominal tumors. Radiology 1986; 161: 309.
- Banner M. Percutaneous renal cyst ablation. In: Radiologic Interventions Uroradiology. Baltimore: Williams and Wilkins; 1998. 73-77.
- Vaughn E. D., Jr., Sosa E. R. Angioinfarction. Renovascular hypertension and other renal vascular lesions. In: Walsh P. С et al. Eds. Campbell's Urology. Philadelphia: W. B. Saunders; 1998. 446.
- Talwar G. L., Pande S. K. Injection treatment for enlarged prostate. Br. J. Surg, 1996; 53: 421.
- Harmon W. J., Barrett D. M., Qian J. et al. Transurethral enzymatic ablation of the prostate: canine model. Urology, 1996; 48: 229.
- Levy D. A., Cromeens D. M., Evans R. et al. Transurethral ultrasound-guided intraprostatic injection of absolute alcohol with and without carmustine: a feasibility study in the canine model. Urology, 1999; 53: 1245.
- Littrup P. J., Lee F., Borlanza G. S. et al. Percutaneous ablation of canine prostate using transrectal ultrasound guidance, absolute ethanol and Nd: YAG laser.Invest. Radiol. 1988; 23: 734.
- Zvara P., Karpman E., Stoppacher R. et al. Ablation of canine prostate using transurethral intraprostatic absolute ethanol injection. Urology. 1999; 54: 411.
- Zvara P., Li C., Karpman E. et al. Prostate chemoablation with transurethral ethanol injection: experimental study. Endoskopie 2000; 9: 43.
- Plante M. К., Gross A. L., Klimeni J. /ret al. Intraprostatic ethanol chemoablation via transurethral and transperineal injection. Br. J. Urol. 2003; 91: 94.
- Goya N., Ishikawa N., Ito F. et al. Ethanol injection therapy of the prostate for benign prostatic hyperplasia: preliminary report on application of a new technique. J. Urol.(Baltimore) 1999; 162: 383.
Дополнительные файлы
![](/img/style/loading.gif)