Дефицит витамина D, метаболический синдром и аденома предстательной железы: современные эпидемиологические тренды и патофизиологические механизмы взаимодействия


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Аннотация

В обзоре на основании результатов современных эпидемиологических и клинико-экспериментальных исследований рассматривается важная патофизиологическая роль витамина D и нарушений его обмена (дефицита/недостаточности) в патогенезе метаболического синдрома (МС) у мужчин, который, согласно имеющимся данным литературы, достоверно ассоциируется с аденомой предстательной железы (АПЖ). Представлены общие сведения об эндокринологии витамина D и его роли в поддержании различных аспектов здоровья мужчин. Проведен анализ известных к настоящему времени потенциальных патофизиологических механизмов с участием витамина D, взаимодействующих в рамках патогенеза МС и АПЖ. В настоящее время существует много доказательств того, что МС и АПЖ имеют общие универсальные взаимодействующие механизмы патогенеза (ожирение, инсулинорезистентность, дислипидемия, системное хроническое субклиническое воспаление, эндотелиальная дисфункция), которые реализуются при непосредственном участии витамина D. Высказана точка зрения, согласно которой на фоне глобального дефицита витамина D в современной популяции, сопровождающегося ускоренным ростом частоты как МС, так и АПЖ и их существенным омоложением, рациональное управление обменом витамина D у мужчин может рассматриваться как перспективная и эффективная патогенетическая опция профилактики как МС, так и АПЖ.

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О. И Братчиков

ФГБОУ ВО «Курский государственный медицинский университет»

Email: bratov45@mail.ru
д.м.н., профессор, акад. РАЕН, Заслуженный врач РФ, зав. кафедрой урологии

С. О Артищев

ФГБОУ ВО «Курский государственный медицинский университет»

Email: Sergey-artischev@yandex.ru
аспирант кафедры урологии

И. А Тюзиков

Клиника профессора Калинченко

Email: phoenix-67@list.ru
к.м.н., профессор РАЕН, Заслуженный работник науки и образования, научный консультант

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