Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)

A. D Protasov; Протасов А. Д; I. S Lipatov; Липатов И. С; M. P Kostinov; Костинов М. П; Yu. V Tezikov; Тезиков Ю. В; A. D Shmit’ko; Шмитько А. Д; D. V Pakhomov; Пахомов Д. В; D. A Blagovidov; Благовидов Д. А; A. V Zhestkov; Жестков А. В; A. A Ryzhov; Рыжов А. А; E. V Vekhova; Вехова Е. В

Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)

作者: Protasov A.D¹, Lipatov I.S¹, Kostinov M.P², Tezikov Y.V¹, Shmit’ko A.D², Pakhomov D.V², Blagovidov D.A², Zhestkov A.V¹, Ryzhov A.A², Vekhova E.V³
隶属关系:
1. Samara State Medical University
2. I.I. Mechnikov Research Institute of Vaccines and Sera
3. Samara Regional Center for Prevention and Control of AIDS and Infectious Diseases
期: 编号 5 (2016)
页面: 47-51
栏目: Articles
URL: https://journals.eco-vector.com/1728-2985/article/view/286544
ID: 286544

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Aim To evaluate the effectiveness of combined use of the imiquimod 5% cream and vaccination against human papillomavirus (HPV) using a quadrivalent recombinant vaccine to achieve long-term clinical remission of chronic HPV infection manifested by anogenital warts. Material and methods The study comprised 36 patients, including 22 men, aged 26.4±4.1 years, who had from 1 to 5 anogenital warts. Participants of the study were vaccinated by quadrivalent recombinant vaccine under a 3-dose scheme 0-2-6 months co-administered with imiquimod 5% cream three times per week up to 16 weeks. The follow-up period was 2 years. Results Complete disappearance of genital warts within 1 year from baseline was observed in 34 (94.4%) patients. Two patients with anogenital warts after 1 year were treated for 1 year 3 months and 1 year and 4 months with Solcoderm which lead to the complete disappearance of genital warts. There were no recurrences of genital warts during the 2 years of follow-up. Conclusion Vaccination with a recombinant quadrivalent vaccine concurrently with using imiquimod 5% cream results in prolonged clinical remission of chronic HPV infection manifested by anogenital warts in at least 94.4% of the cases (2 year follow-up).

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HPV infection, genital warts, vaccination, vaccine against human papillomavirus quadrivalent recombinant, imiquimod, the combined use of

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Howell-Jones R., de Silva N., Akpan M., Oakeshott P., Carder C., Coupland L. et al. Prevalence of human papillomavirus (HPV) infections in sexually active adolescents and young women in England, prior to widespread HPV immunization. Vaccine. 2012;30(26):3867-3875. doi: 10.1016/j.vaccine.2012.04.006.
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Кузнецова Ю.Н. Лечение остроконечных кондилом аногенитальной области препаратом Солкодерм. Уральский медицинский журнал. 2005;3:2-3
Аполихина И.А., Салех Ю.В. Современные возможности в лечении остроконечных кондилом. Акушерство и гинекология. 2011;5:134-136
Неймарк Б.А., Кондратьева Ю.С., Зологина В.С., Торбик Д.В. Эффективность комбинированного лечения папилломавирусной инфекции. Урология. 2015;2:39-42
Hengge U.R., Benninghoff B., Ruzicka T., Gooset M. Topical immunomodulators - progress towards treating inflammation, infection, and cancer. Lancet Infectious Diseases. 2001;1(3):189-198. DOI: http://dx.doi.org/10.1016/S1473-3099(01)00095-0.

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Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)

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关键词

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作者简介

A. Protasov

I. Lipatov

M. Kostinov

Yu. Tezikov

A. Shmit’ko

D. Pakhomov

D. Blagovidov

A. Zhestkov

A. Ryzhov

E. Vekhova

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