Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)

A. D Protasov; Протасов А. Д; I. S Lipatov; Липатов И. С; M. P Kostinov; Костинов М. П; Yu. V Tezikov; Тезиков Ю. В; A. D Shmit’ko; Шмитько А. Д; D. V Pakhomov; Пахомов Д. В; D. A Blagovidov; Благовидов Д. А; A. V Zhestkov; Жестков А. В; A. A Ryzhov; Рыжов А. А; E. V Vekhova; Вехова Е. В

Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)

Authors: Protasov A.D¹, Lipatov I.S¹, Kostinov M.P², Tezikov Y.V¹, Shmit’ko A.D², Pakhomov D.V², Blagovidov D.A², Zhestkov A.V¹, Ryzhov A.A², Vekhova E.V³
Affiliations:
1. Samara State Medical University
2. I.I. Mechnikov Research Institute of Vaccines and Sera
3. Samara Regional Center for Prevention and Control of AIDS and Infectious Diseases
Issue: No 5 (2016)
Pages: 47-51
Section: Articles
URL: https://journals.eco-vector.com/1728-2985/article/view/286544
ID: 286544

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Abstract

Aim To evaluate the effectiveness of combined use of the imiquimod 5% cream and vaccination against human papillomavirus (HPV) using a quadrivalent recombinant vaccine to achieve long-term clinical remission of chronic HPV infection manifested by anogenital warts. Material and methods The study comprised 36 patients, including 22 men, aged 26.4±4.1 years, who had from 1 to 5 anogenital warts. Participants of the study were vaccinated by quadrivalent recombinant vaccine under a 3-dose scheme 0-2-6 months co-administered with imiquimod 5% cream three times per week up to 16 weeks. The follow-up period was 2 years. Results Complete disappearance of genital warts within 1 year from baseline was observed in 34 (94.4%) patients. Two patients with anogenital warts after 1 year were treated for 1 year 3 months and 1 year and 4 months with Solcoderm which lead to the complete disappearance of genital warts. There were no recurrences of genital warts during the 2 years of follow-up. Conclusion Vaccination with a recombinant quadrivalent vaccine concurrently with using imiquimod 5% cream results in prolonged clinical remission of chronic HPV infection manifested by anogenital warts in at least 94.4% of the cases (2 year follow-up).

Keywords

HPV infection, genital warts, vaccination, vaccine against human papillomavirus quadrivalent recombinant, imiquimod, the combined use of

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Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)

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Abstract

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