EJACULATE AND SERUM PROCALCITONIN LEVELS IN HEALTHY MEN AND MEN WITH OLIGOASTHENOZOOSPERMIA
- Authors: Sosnin D.Y.1, Zubareva N.A1, Nenasheva O.Y.1, Krivtsov A.V2, Karimova N.V1, Pozdin N.V3
-
Affiliations:
- E.A. Vagner Perm State Medical Academy of Minzdrav of Russia
- Federal Research Center of Medical and Preventive Technologies for Public Health Risk Management, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
- Perm National Research Polytechnic University
- Issue: No 1 (2017)
- Pages: 61-65
- Section: Articles
- URL: https://journals.eco-vector.com/1728-2985/article/view/286751
- DOI: https://doi.org/10.18565/urol.2017.1.61-65
- ID: 286751
Cite item
Open Access
Access granted
Abstract
Introduction Seminal plasma composition reflects the activity of reproductive organs involved in the semen production. Aim. To study procalcitonin concentrations in serum and semen samples of healthy men and men with oligoasthenozoospermia. Methods .The study included 88 men, who were scheduled for diagnostic evaluation to establish the cause of infertile marriages. The study group comprised 40 men with oligoasthenozoospermia, the comparison group included 48 men with normal sperm concentration. Laboratory testing of all participants revealed no abnormal findings in blood count, blood chemistry studies and urinalysis. Results. Mean seminal plasma procalcitonin level in the study subjects (n=87) was 0,349+0,370 ng/ml being about 10 times higher than its serum level, which was 0.037±0.027 ng/ml (p<0.000001). In the study group, seminal plasma PCT concentration was significantly greater than in the control group (p=0.0095), while the serum procalcitonin levels in all participants were almost identical (p=0.605). There were no statistically significant correlations between the procalcitonin levels and spermatozoa concentration, total count and ejaculate volume. Conclusions. The findings suggest that elevated levels of procalcitonin in seminal plasma can be regarded as an unfavorable prognostic factor, indicating the reduced ejaculate fertility. Further studies seem warranted, specifically considering the role and source of procalcitonin production in sperm.
Keywords
Full Text
About the authors
D. Yu Sosnin
E.A. Vagner Perm State Medical Academy of Minzdrav of Russia
Email: sosnin_dm@mail.ru
Dr.Med.Sci., Associate Professor at the Department of Clinical Laboratory Diagnostics Perm, Russia
N. A Zubareva
E.A. Vagner Perm State Medical Academy of Minzdrav of RussiaDr.Med.Sci., Professor at Department of General Surgery № 1 Perm, Russia
O. Yu Nenasheva
E.A. Vagner Perm State Medical Academy of Minzdrav of RussiaPhD, Associate Professor at the Department of Clinical Laboratory Diagnostics, Faculty of Postgraduate Education Perm, Russia
A. V Krivtsov
Federal Research Center of Medical and Preventive Technologies for Public Health Risk Management, Federal Service for Surveillance on Consumer Rights Protection and Human WellbeingPhD, Head of the Laboratory of Immunogenetics Perm, Russia
N. V Karimova
E.A. Vagner Perm State Medical Academy of Minzdrav of RussiaIntern at the Department of Clinical Laboratory Diagnostics, Faculty of Postgraduate Education Perm, Russia
N. V Pozdin
Perm National Research Polytechnic UniversityStudent of the Faculty of Applied Mathematics and Mechanics Perm, Russia
References
- Долгов В.В., Луговская С.А, Фанченко Н.Д., Миронова И.И., Назарова Е.К., Ракова Н.Г., Раков С.С., Селиванов Т.О., Щелочков А.М. Лабораторная диагностика мужского бесплодия. М.-Тверь: ООО «Издательство «Триада», 2006. 125 с
- WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. - 4th ed. 1999.
- WHO laboratory manual for the examination and processing ofhuman semen. - 5th ed. 2010 http://www.who.int/reproductivehealth/publications/infertility/9789241547789/en/ ссылка активна на 20.10.2016.
- Галькович К.Р., Соснин Д.Ю. Иммунохимическое определение концентрации органоспецифических белков эякулята в дифференциальной диагностике хронических воспалительных заболеваний мужской репродуктивной системы. Урология. 1997;(5):40-44
- Галькович К.Р., Соснин Д.Ю. Иммунохимическое определение концентрации иммуноглобулинов в эякуляте для диагностики хронических воспалительных заболеваний мужской репродуктивной системы. Клиническая лабораторная диагностика. 2000;(1):22-35
- Евдокимов В.В., Ерасова В.И., Орлова Е.В. Белковые маркеры фертильности. Андрология и генитальная хирургия. 2004;(4):30-32
- Евдокимов В.В. Голованов С.А., Дрожжева В.В., Ерасова В.И. Биохимические параметры эякулята. Андрология и генитальная хирургия. 2007;(3):5-9
- Луцкий Д.Л., Махмудов Р.М. Луцкая А.М. Исследование эякулята и его компонентов в диагностике воспалительных заболеваний мужской репродуктивной системы: белки, антиспермальные антитела. Часть 2 (обзор литературы). Проблемы репродукции. 2011;(2): 84-88
- Andrei P.D., Keith J., Eleftherios P.D. Verification of male infertility biomarkers inseminal plasma by multiplex selected reaction monitoring assay. Molecular & Cellular Proteomics. 2011;(10):13. doi: 10.1074/mcp.M110.004127-1.
- Davalieva K., Kiprijanovska S., Noveski P., Plaseski T., Kocevska B., Plaseska-Karanfilska D. Human seminal plasma proteome study: a search for male infertility biomarkers. BJMG. 2012;(15 Suppl):35-38. doi: 10.2478/v10034-012-0016-9
- Milardi D., Grande G., Vincenzoni F., Castagnola M., Marana R. Proteomics of human seminal plasma: identification of biomarker candidates for fertility and infertility and the evolution of technology. Molecular reproduction and development. 2013;80(5):350-357. doi: 10.1002/mrd.22178.
- Drabovich A.P., Saraon P., Jarvi K., Diamandis E.P. Seminal plasma as a diagnostic fluid for male reproductive system disorders. Nature reviews. Urology. 2014;11(5):278-288. Doi: 10.1038/ nrurol.2014.74.
- Milardi D., Grande G., Vincenzoni F., Castagnola M., Marana R. Proteomics of human seminal plasma: identification of biomarker candidates for fertility and infertility and the evolution of technology. Molecular reproduction and development. 2013;80(5):350-357. doi: 10.1002/mrd.22178.
- Davies J. Procalcitonin. J. Clin Pathol. 2015;68(9):675-79. doi: 10.1136/jclinpath-2014-202807.
- Albrich W.C., Harbarth S. Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting. Intensive Care Med. 2015;41(10):1739-1751. doi: 10.1007/s00134-015-3978-8.
- Osthoff M., Eisen D.P. Procalcitonin as a diagnostic marker for sepsis. Lancet Infect Dis. 2013;13(12):1013-14. doi: 10.1016/s1473-3099(13)70301-3.
- Wacker C., Prkno A., Brunkhorst F.M., Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and metaanalysis. Lancet Infect Dis. 2013;13(5):426-35. doi: 10.1016/s1473-3099(12)70323-7.
- Slavakis A., Papadimas J. Procalcitonin: does it play a role in malt reproduction? Fertil Steril 2000;74(6):1227-28. doi: 10.1016/s0015-0282(00)01588-0.
- Autillo C., Morelli R., Milardi D., Grande G., Marana R., Pontecorvi A., Zuppi C., Baroni S. Soluble urokinase-type plasminogen activator receptor as a putative marker of male accessory gland inflammation. Andrology. 2015;3(6): 1054-61. doi: 10.1111/andr.12084.
- Thomas St., Kratzsh D., Schaab M., Scholz M., Grünewald S., Thiery J., Paasch U., Kratzch Ju. Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa. Fertil Steril 2013;99(5):1256-63. doi: 10.1016/j.fertnstert.2012.12.022
Supplementary files
