The features of the pathologic changes in chronic oxalate stone disease after 16 week of experimental phase


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Aim. to study the pathologic features of chronic oxalate stone disease. Materials and methods. a model of the experimental oxalate stone disease was done in rats that drank the 1% ethylene glycol solution for 16 weeks. The pathologic analysis of the rats’ kidneys was done. Results. After 16 weeks of oxalate stone disease modeling in all parts of kidneys the large crystals deposits were found, which plugged renal tubules. Moreover, purulent calculous pyelonephritis developed complicated by fibrosis.

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作者简介

G. Zharikova

FGBOU VO «Altai State Medical University» of the Ministry of Health of Russia

Email: ganna1704@mail.ru
Lecturer at the Department ofGeneral and Biological Chemistry, clinical diagnostic laboratory

V. Bryukhanov

FGBOU VO «Altai State Medical University» of the Ministry of Health of Russia

Email: bvm@agmu.ru
Dr.Med.Sci, professor at the Department of Pharmacology

A. Neymark

FGBOU VO «Altai State Medical University» of the Ministry of Health of Russia

Email: urologagmu@mail.ru
Dr.Med.Sci, professor, Department of Specialized Surgery

A. Zharikov

FGBOU VO «Altai State Medical University» of the Ministry of Health of Russia

Email: zharikov_a_y@mail.ru
Dr.Bio.Sci., associate professor, Head of the Department of Pharmacology

I. Bobrov

FGBOU VO «Altai State Medical University» of the Ministry of Health of Russia

Email: ig.bobrov2010@yandex.ru
Dr.Med.Sci, head of the pathological laboratory of the Center of Medical and Biologic Studies

N. Yakushev

FGBOU VO «Altai State Medical University» of the Ministry of Health of Russia

Email: yakushevnn@mail.ru
Cand.Med.Sci., associate professor at the Department of Pharmacology

参考

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